CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15222
Family Name Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ligand NCGC00024664-01 family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00278639 Functional Category Bioactive with Natural Product
Superfamily Envelope glycoprotein gp120 Inhibitor BMS-488043 Superfamily
Class Class 1163

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Integrin beta-3 Inhibitor L-756568 Family 8 59
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Alpha-1A adrenergic receptor Ligand A-131701 Family 16 17
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand WIN-5... 12 52
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
D(2) dopamine receptor Ligand SLV-314 Family 19 69
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... 32 64
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Reverse transcriptase Inhibitor Atevirdine Family 4 55
5-hydroxytryptamine receptor 1A and Alpha-1A adrenergic recept... 28 24
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Disintegrin and metalloproteinase domain-containing protein 17... 14 9
Disintegrin and metalloproteinase domain-containing protein 17... 2 8
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 3 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 4 1
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... 6 22
D(4) dopamine receptor and D(2) dopamine receptor ligand 1-(2-... 3 3
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 11
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 2 0
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... 3 4
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... 4 8
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... 7 3
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Substance-P receptor ligand AGN-PC-01VLKE family 9 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Disintegrin and metalloproteinase domain-containing protein 17... 5 4
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 1 1
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 5 3
Vasopressin V2 receptor ligand SureCN4400636 family 1 0
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Macrophage colony-stimulating factor 1 receptor ligand 4-(2,3-... 12 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
Adenosine receptor A2b and Adenosine receptor A1 ligand [4-(2,... 6 15
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand 9-prop... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Amine oxidase [flavin-containing] B and Amine oxidase [flavin-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432909 CHEMBL54716 Bioactive 3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-1,5-dimethylpyrimido[5,4-b]indole-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27254 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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