CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15224
Family Name Neprilysin and Angiotensin-converting enzyme inhibitor 2-[(3S)-4-oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3-dihydro-1,5-benzoxazepin-5-yl]acetic acid family
No. of Seeds 5 No. of Other Members 6
Family Centroid CFAMM00432926 Functional Category Bioactive
Superfamily Neprilysin and Neurotensin receptor type 1 Binder Superfamily
Class Class 1297

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 6 23
Substance-K receptor Ligand MEN-14933 Family 13 154
Alpha-1A adrenergic receptor Ligand Upidosin Family 8 46
Leukotriene A-4 hydrolase Inhibitor N5-[4-(4-(3-furyl)phenoxy)... 7 71
Renin inhibitor 5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4... 5 9
Furin inhibitor phenyl 2-[[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbami... 2 5
E3 ubiquitin-protein ligase XIAP inhibitor (2S)-N-[(3S)-5-[[2-... 1 0


External ID

Functional Category

Molecule Name

CFAMM00432927 CHEMBL301751 Bioactive 3-[(3S)-4-oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3-dihydro-1,5-benzoxazepin-5-yl]propanoic acid
CFAMM00432933 CHEMBL89760 Bioactive 2-[(3S)-3-[[(2R)-2-benzyl-3-[formyl(hydroxy)amino]propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]acetic acid
CFAMM00432926 CHEMBL54036 Bioactive 2-[(3S)-4-oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3-dihydro-1,5-benzoxazepin-5-yl]acetic acid
CFAMM00432931 CHEMBL50559 Bioactive 2-[(2S,3S)-2-methyl-4-oxo-3-[[(2S)-3-phenyl-2-sulfanylpropanoyl]amino]-2,3-dihydro-1,5-benzoxazepin-5-yl]acetic acid
CFAMM00432929 CHEMBL51389 Bioactive 2-[(3S)-3-[[(2S)-2-benzyl-3-sulfanylpropanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]acetic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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