CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15227
Family Name Integrin beta-3 and Integrin alpha-V inhibitor 2-[(2S)-4-methyl-3-oxo-7-[2-(pyridin-2-ylamino)ethylcarbamoyl]-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00432950 Functional Category Bioactive
Superfamily Integrin beta-3 and Integrin alpha-V Binder Superfamily 24
Class Class 639

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Folate receptor gamma Ligand Folic Acid Family 4 100
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Dabigatran Family 7 182
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
BIBT986 family 7 96
Histone deacetylase 6 Inhibitor ACY-1215 Family 10 230
CP-18770 family 6 27
XL-888 family 16 85
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
Cyclin-dependent kinase 4 Inhibitor 1-(9-oxo-9h-fluoren-4-yl)-... 3 5
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Adenosine receptor A1 and Adenosine receptor A3 Ligand VUF-850... 28 47
Transient receptor potential cation channel subfamily V member... 6 23
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Metabotropic glutamate receptor 5 Ligand 3-cyano-5-fluoro-n-(p... 2 9
Cholecystokinin receptor type A ligand A-65186 family 2 6
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Prelamin-A/C and Tyrosyl-DNA phosphodiesterase 1 inhibitor nif... 1 0
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 3 5
Dipeptidyl peptidase 4 and Potassium voltage-gated channel sub... 9 0
Caspase-1 inhibitor (3S)-4-oxo-3-[[6-[[4-(quinoxalin-2-ylamino... 5 6
Aurora kinase A and Aurora kinase B inhibitor 4-fluoro-N-[4-[(... 6 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Integrin alpha-V and Integrin beta-6 inhibitor 3-[[2-[4-[(4-me... 4 3
Integrin beta-3 and Integrin alpha-IIb inhibitor 2-[(5S,11S,14... 2 2
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 8 5
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 1
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[4-[3-(dimethylamino)... 106 49
Integrin beta-3 and Integrin alpha-IIb inhibitor (3S)-3-[[2-[(... 3 1
Integrin beta-1 and Integrin alpha-5 inhibitor 2-[(2,6-dimethy... 9 1
Integrin beta-1 and Integrin alpha-5 inhibitor (2S)-3-[4-[4-[[... 2 0
Thymidylate synthase and Dihydrofolate reductase inhibitor (2S... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00432950 CHEMBL301760 Bioactive 2-[(2S)-4-methyl-3-oxo-7-[2-(pyridin-2-ylamino)ethylcarbamoyl]-2,5-dihydro-1H-1,4-benzodiazepin-2-yl]acetic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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