CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15259
Family Name Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-1-pyridin-3-ylpyrrolidine-2-carbonyl]amino]propanoic acid family
No. of Seeds 3 No. of Other Members 15
Family Centroid CFAMM00433060 Functional Category Bioactive
Superfamily Integrin beta-1 and Integrin alpha-4 Binder Superfamily 5
Class Class 4486

Cousin Family NamesSeedsMembers
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Integrin alpha-4 Inhibitor Firategrast Family 3 93
Smoothened homolog Inhibitor LDE225 Family 3 76
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Integrin alpha-V and Integrin beta-1 Inhibitor SB-265123 Family 30 170
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 8 57
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Renin Inhibitor CP-305202 Family 9 30
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V1a receptor and Vasopressin V2 receptor ligand [4... 1 2
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Prostaglandin E2 receptor EP3 subtype and Prostaglandin E2 rec... 4 20
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
cGMP-specific 3',5'-cyclic phosphodiesterase and Cytochrome P4... 5 0
cAMP-dependent protein kinase type II-alpha regulatory subunit... 2 4
Somatostatin receptor type 5 ligand AGN-PC-080TDB family 10 14
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... 2 5
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 13 0
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... 2 8
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Potassium voltage-gated channel subfamily H member 2 and Kappa... 5 33
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 4 6
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Thromboxane-A synthase and Thromboxane A2 receptor ligand Sure... 5 37
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 0
Prostaglandin D2 receptor 2 ligand SureCN137822 family 3 0
Voltage-dependent T-type calcium channel subunit alpha-1I liga... 2 6
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 2 2
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 1 14
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 4 11
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... 3 0
Peroxisome proliferator-activated receptor gamma and Peroxisom... 3 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Potassium voltage-gated channel subfamily KQT member 2 ligand ... 3 4
C-C chemokine receptor type 2 ligand (E)-1-[4-[2-hydroxy-1-[4-... 2 2
Vasopressin V2 receptor and Vasopressin V1a receptor ligand 2-... 1 26
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 4 1
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-3-[4-(2,6-... 3 1
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Leukotriene A-4 hydrolase inhibitor SureCN3030546 family 9 1
Renin inhibitor SureCN7300793 family 2 5
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Endothelin-converting enzyme 1 inhibitor 3-[6-(furan-2-yl)pyri... 2 1
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433058 CHEMBL303396 Bioactive (2S)-3-[4-(2-methoxyphenyl)phenyl]-2-[(1-pyridin-3-ylcyclopentanecarbonyl)amino]propanoic acid
CFAMM00433050 CHEMBL71705 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-1-isoquinolin-4-ylpyrrolidine-2-carbonyl]amino]propanoic acid
CFAMM00433060 CHEMBL69352 Bioactive (2S)-3-[4-(2,6-dimethoxyphenyl)phenyl]-2-[[(2S)-1-pyridin-3-ylpyrrolidine-2-carbonyl]amino]propanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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