Cousin Family Names | Seeds | Members |
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Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... | 12 | 93 |
Cysteinyl leukotriene receptor 1 Ligand Zafirlukast Family | 48 | 78 |
Melatonin receptor type 1A Ligand Melatonin Family | 20 | 988 |
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... | 2 | 136 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... | 28 | 2712 |
Cyclooxygenase Inhibitor Indomethacin Family | 6 | 271 |
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family | 93 | 156 |
ostatin receptor 5 Ligand Pasireotide Diaspartate Family | 11 | 151 |
Mast/stem cell growth factor receptor Kit and Vascular endothe... | 1 | 4 |
Coagulation factor X Inhibitor Apixaban Family | 34 | 52 |
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... | 3 | 284 |
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 12 | 197 |
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 4 | 42 |
Indeglitazar family | 3 | 39 |
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... | 3 | 21 |
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... | 37 | 265 |
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... | 21 | 194 |
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... | 3 | 52 |
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... | 12 | 81 |
5-hydroxytryptamine receptor 1B Ligand GR55562 Family | 3 | 45 |
Peroxisome proliferator-activated receptor gamma and Peroxisom... | 15 | 94 |
Melatonin receptor type 1B Ligand N-(3-benzooxazol-7-yl-propyl... | 26 | 101 |
Substance-K receptor and Substance-P receptor Ligand L-732138 ... | 8 | 147 |
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... | 3 | 19 |
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... | 9 | 80 |
Integrin beta-3 Inhibitor L-756568 Family | 8 | 59 |
Cannabinoid receptor 2 Ligand JWH-202 Family | 9 | 172 |
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... | 6 | 292 |
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... | 3 | 85 |
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family | 4 | 70 |
Cholecystokinin receptor type A Ligand VL-0395 Family | 12 | 117 |
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... | 3 | 44 |
Platelet-derived growth factor receptor alpha and Platelet-der... | 4 | 54 |
Platelet-derived growth factor receptor alpha and Platelet-der... | 2 | 13 |
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... | 67 | 59 |
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... | 14 | 214 |
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... | 14 | 33 |
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... | 3 | 27 |
Neutrophil elastase Inhibitor Cbz-val-pro-val-(2-benzoxazole) ... | 32 | 64 |
High affinity nerve growth factor receptor and Mitogen-activat... | 2 | 7 |
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... | 9 | 69 |
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... | 53 | 320 |
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... | 5 | 75 |
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 24 | 64 |
Reverse transcriptase Inhibitor Atevirdine Family | 4 | 55 |
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... | 2 | 31 |
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family | 7 | 34 |
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... | 18 | 72 |
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... | 1 | 4 |
Fatty-acid amide hydrolase 1 Inhibitor 3-(benzo[d]oxazol-2-yl)... | 1 | 6 |
Melatonin receptor type 1B and Melatonin receptor type 1A liga... | 3 | 16 |
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... | 7 | 44 |
Tyrosine-protein kinase SYK and Low affinity immunoglobulin ep... | 1 | 0 |
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[3-(1,3-be... | 3 | 2 |
Disintegrin and metalloproteinase domain-containing protein 17... | 14 | 9 |
Cannabinoid receptor 1 and 5-hydroxytryptamine receptor 1A lig... | 2 | 12 |
Glycogen synthase kinase-3 beta and Protein kinase C alpha typ... | 2 | 30 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 9 | 0 |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 1 | 14 |
Histamine H3 receptor and Potassium voltage-gated channel subf... | 2 | 21 |
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... | 4 | 41 |
Disintegrin and metalloproteinase domain-containing protein 17... | 2 | 8 |
Histamine H3 receptor and Potassium voltage-gated channel subf... | 3 | 11 |
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... | 3 | 18 |
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... | 10 | 4 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 6 |
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... | 7 | 9 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 14 | 48 |
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... | 3 | 5 |
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... | 4 | 4 |
Vascular endothelial growth factor receptor 2 ligand indolyl q... | 2 | 1 |
Muscarinic acetylcholine receptor M2 and Acetylcholinesterase ... | 4 | 24 |
Acetylcholinesterase and Muscarinic acetylcholine receptor M2 ... | 2 | 7 |
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 8 | 32 |
Neuronal acetylcholine receptor subunit alpha-7 ligand 2-[3-cy... | 2 | 5 |
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 8 | 21 |
Somatostatin receptor type 5 and Somatostatin receptor type 1 ... | 2 | 8 |
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... | 4 | 2 |
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 2 | 5 |
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... | 4 | 14 |
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... | 18 | 32 |
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family | 4 | 9 |
Histamine H3 receptor ligand AGN-PC-00BG7Z family | 11 | 49 |
Histamine H3 receptor ligand (4S)-7-bromo-4-methyl-8-(1-propan... | 2 | 0 |
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 10 | 50 |
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... | 4 | 6 |
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... | 2 | 21 |
Renin inhibitor AGN-PC-09M9MJ family | 2 | 23 |
Sodium channel protein type 10 subunit alpha and Sodium channe... | 3 | 22 |
Disintegrin and metalloproteinase domain-containing protein 17... | 4 | 1 |
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... | 8 | 2 |
Cysteinyl leukotriene receptor 1 ligand AGN-PC-075KCE family | 5 | 33 |
Prelamin-A/C inhibitor CHEMBL1374443 family | 1 | 6 |
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... | 1 | 15 |
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... | 5 | 2 |
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... | 2 | 15 |
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... | 4 | 53 |
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... | 3 | 3 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... | 2 | 9 |
Cellular tumor antigen p53 inhibitor CHEMBL1395699 family | 1 | 30 |
B2 bradykinin receptor ligand SureCN6640854 family | 7 | 4 |
D(2) dopamine receptor and D(4) dopamine receptor ligand N-[3-... | 6 | 22 |
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family | 2 | 11 |
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... | 1 | 16 |
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... | 8 | 3 |
Translocator protein inhibitor N-(4-methoxyphenyl)-N,3-dimethy... | 2 | 2 |
Cellular tumor antigen p53 and Microtubule-associated protein ... | 1 | 15 |
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 4 | 11 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 2 | 0 |
D(3) dopamine receptor ligand N-[4-[4-(2,3-dichlorophenyl)pipe... | 3 | 15 |
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... | 2 | 0 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 3 | 21 |
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... | 2 | 3 |
Cannabinoid receptor 1 ligand 5-cyano-N-(3-hydroxy-2,2-dimethy... | 17 | 4 |
Melatonin receptor type 1A and Melatonin receptor type 1B liga... | 2 | 0 |
Coagulation factor X and Trypsin-1 inhibitor AGN-PC-0759OR family | 4 | 7 |
Coagulation factor X and Prothrombin inhibitor 6-[4-[2-[[(3R)-... | 15 | 2 |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... | 5 | 12 |
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... | 4 | 1 |
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 5 |
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 3 | 2 |
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... | 2 | 19 |
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... | 1 | 16 |
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1801290 ... | 3 | 0 |
Histone deacetylase 1 and Potassium voltage-gated channel subf... | 1 | 0 |
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... | 5 | 12 |
C-C chemokine receptor type 2 and Potassium voltage-gated chan... | 4 | 11 |
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... | 16 | 19 |
Mu-type opioid receptor ligand AGN-PC-075GBK family | 4 | 4 |
D(2) dopamine receptor and Alpha-1B adrenergic receptor ligand... | 3 | 4 |
NS5B protein inhibitor AC1O5AET family | 3 | 1 |
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 3-... | 4 | 8 |
Renin and Potassium voltage-gated channel subfamily H member 2... | 4 | 0 |
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... | 19 | 10 |
Glucagon receptor ligand 3-[[4-[(2S)-2-[5-(trifluoromethoxy)-1... | 1 | 2 |
D(2) dopamine receptor and D(3) dopamine receptor ligand N-[3-... | 7 | 3 |
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... | 13 | 1 |
Disintegrin and metalloproteinase domain-containing protein 17... | 1 | 2 |
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... | 9 | 10 |
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... | 8 | 4 |
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... | 14 | 2 |
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... | 8 | 1 |
D(3) dopamine receptor ligand AGN-PC-075Z0O family | 2 | 3 |
Vascular endothelial growth factor receptor 2 and Vascular end... | 2 | 52 |
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... | 3 | 2 |
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... | 11 | 13 |
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... | 2 | 2 |
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... | 2 | 3 |
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... | 3 | 4 |
Disintegrin and metalloproteinase domain-containing protein 17... | 13 | 3 |
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... | 11 | 12 |
Smoothened homolog and Mitogen-activated protein kinase 14 inh... | 3 | 0 |
Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 12 | 0 |
Disintegrin and metalloproteinase domain-containing protein 17... | 16 | 2 |
Plasmepsin-2 and Cathepsin D inhibitor 4-[4-[[(2S,3S)-1-[[(3S,... | 3 | 0 |
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... | 42 | 20 |
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... | 5 | 3 |
Coagulation factor X and Prothrombin inhibitor 1-(4-methoxyphe... | 8 | 0 |
Growth hormone secretagogue receptor type 1 ligand SureCN36800... | 14 | 42 |
Microsomal triglyceride transfer protein large subunit inhibit... | 9 | 0 |
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... | 3 | 0 |
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... | 6 | 2 |
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... | 4 | 6 |
Substance-P receptor ligand AGN-PC-01VLKE family | 9 | 11 |
Coagulation factor X inhibitor SureCN6785555 family | 7 | 0 |
Acetylcholinesterase and Cholinesterase inhibitor N-[5-[(6-chl... | 4 | 2 |
Peroxisome proliferator-activated receptor delta and Peroxisom... | 7 | 5 |
Beta-2 adrenergic receptor ligand SureCN5346426 family | 8 | 0 |
Beta-2 adrenergic receptor ligand SureCN4598646 family | 7 | 7 |
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... | 4 | 3 |
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... | 1 | 3 |
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... | 7 | 11 |
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... | 5 | 14 |
Leucine-rich repeat serine/threonine-protein kinase 2 and Vasc... | 1 | 1 |
Growth hormone secretagogue receptor type 1 ligand N-[(1R)-2-(... | 3 | 2 |
Serine/threonine-protein kinase PLK4 inhibitor (3E)-5-methoxy-... | 4 | 0 |
Disintegrin and metalloproteinase domain-containing protein 17... | 5 | 4 |
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... | 1 | 0 |
C-C chemokine receptor type 5 ligand N-methyl-4-[6-methyl-5-[[... | 2 | 2 |
Disintegrin and metalloproteinase domain-containing protein 17... | 5 | 0 |
Glutamate receptor ionotropic, NMDA 2B ligand SureCN5532501 fa... | 1 | 0 |
Melanin-concentrating hormone receptor 1 and Melanin-concentra... | 1 | 0 |
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... | 3 | 2 |
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... | 1 | 1 |
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... | 2 | 2 |
Platelet-activating factor receptor ligand N,N-dimethyl-6-phen... | 12 | 18 |
Neutrophil collagenase and Stromelysin-1 inhibitor (3R)-N-hydr... | 2 | 0 |
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 1 | 0 |
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... | 4 | 20 |
Mu-type opioid receptor ligand MITRAGYNINE family | 2 | 8 |
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... | 2 | 1 |
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... | 1 | 4 |
Substance-P receptor ligand SureCN2139814 family | 7 | 7 |
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... | 3 | 7 |
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... | 2 | 2 |
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... | 2 | 4 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... | 2 | 1 |
Vasopressin V2 receptor ligand SureCN4400636 family | 1 | 0 |
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... | 1 | 1 |
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... | 2 | 10 |
Melatonin receptor type 1B and Melatonin receptor type 1A liga... | 3 | 9 |
Coagulation factor X inhibitor AGN-PC-046RMQ family | 1 | 0 |
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... | 4 | 1 |
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... | 2 | 0 |
Substance-P receptor ligand AGN-PC-00FIT5 family | 3 | 11 |
Substance-P receptor ligand AGN-PC-0D60L0 family | 2 | 7 |
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... | 1 | 0 |
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... | 1 | 2 |
Coagulation factor X inhibitor AGN-PC-077MYE family | 16 | 0 |
Coagulation factor X inhibitor SureCN5644036 family | 30 | 0 |
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... | 6 | 2 |
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... | 2 | 0 |
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family | 2 | 8 |
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... | 5 | 0 |
Histamine H3 receptor ligand SureCN1397929 family | 1 | 1 |
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... | 4 | 1 |
P2Y purinoceptor 12 inhibitor (4S)-4-[[4-[(1-acetylpiperidin-4... | 58 | 15 |
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 6 | 0 |
C-C chemokine receptor type 8 and Potassium voltage-gated chan... | 5 | 1 |
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... | 2 | 4 |
Melatonin receptor type 1A and Melatonin receptor type 1B liga... | 2 | 3 |
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... | 1 | 0 |
Disintegrin and metalloproteinase domain-containing protein 17... | 1 | 0 |
Growth factor receptor-bound protein 2 ligand [4-[(2S)-2-aceta... | 2 | 1 |
Signal transducer and activator of transcription 1-alpha/beta ... | 1 | 36 |
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 2 | 1 |
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... | 1 | 0 |
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... | 2 | 10 |
Potassium voltage-gated channel subfamily A member 5 ligand AG... | 1 | 0 |
Histone deacetylase 1 inhibitor (2S)-2-[[2-(5-methoxy-2-methyl... | 2 | 2 |
Bile acid receptor ligand SureCN1243717 family | 1 | 4 |
Telomerase reverse transcriptase inhibitor N-[9-(4-methoxyanil... | 2 | 0 |
Oxysterols receptor LXR-beta ligand indole derivative, 39 family | 2 | 0 |
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... | 1 | 0 |
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family | 2 | 0 |
Amino Acids and Derivatives Metabolite Flazine Family | 3 | 2 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes. |
How to cite our database |
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
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Last update by |
2014.08.29
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