CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1530
Family Name Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-aminobutyric acid receptor subunit beta-3 ligand 2-(4-ethynylphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one family
No. of Seeds 8 No. of Other Members 10
Family Centroid CFAMM00324617 Functional Category Bioactive
Superfamily Glucocorticoid receptor Ligand 1-(3-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-(1-(4-fluorophenyl)-1h-indazol-5-y L)ethanol (enantiomeric Mix) Superfamily
Class Class 1734

Cousin Family NamesSeedsMembers
DNA Binder Elliptinium Acetate Family 11 116
Citric Acid family 2 58
PF-02545920 family 16 140
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Plasminogen and Prothrombin Inhibitor 2-(2-hydroxy-phenyl)-1h-... 3 69
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
D(2) dopamine receptor and D(3) dopamine receptor Ligand L-741... 9 73
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 13 26
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 12
Oestrogen receptor and Estrogen receptor beta Ligand 4-(3-phen... 5 14
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Acetylcholinesterase and Cholinesterase Inhibitor 6-hydroxy-1,... 4 2
DNA topoisomerase 1 Inhibitor 3-(4-phenyl-2,4'-bipyridin-6-yl)... 4 13
Glucocorticoid receptor Ligand 1-(3-chloro-4-fluorophenyl)-2,2... 1 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 9 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 0
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 5
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 2 10
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Glucocorticoid receptor ligand [(4aR,5S)-1-(4-fluorophenyl)-4a... 27 33
Glucocorticoid receptor ligand [(4aR,5S)-1-(4-fluorophenyl)-4a... 7 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 10
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 33 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6786541 f... 3 6
Proto-oncogene tyrosine-protein kinase receptor Ret ligand Sur... 1 1
Casein kinase I isoform delta and Casein kinase I isoform epsi... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 10 0
Estrogen receptor ligand AGN-PC-00EUMP family 1 6
D(3) dopamine receptor and D(2) dopamine receptor ligand AGN-P... 7 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 2 4
Adenosine receptor A1 ligand 4-amino-2-phenyl-3H-pyrazolo[3,4-... 1 0
Thyroid hormone receptor beta and TGF-beta receptor type-1 lig... 1 1
Estrogen receptor ligand SureCN4030225 family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324611 CHEMBL117931 Bioactive 2-(4-fluorophenyl)-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324617 CHEMBL366384 Bioactive 2-(4-ethynylphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324615 CHEMBL171900 Bioactive 8-ethynyl-2-phenyl-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324622 CHEMBL539172 Bioactive 2-phenyl-1,5-dihydropyrazolo[4,3-c]quinoline-3,9-dione
CFAMM00324614 CHEMBL171901 Bioactive SureCN7347960

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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