CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15303
Family Name Substance-K receptor ligand SureCN9035669 family
No. of Seeds 10 No. of Other Members 5
Family Centroid CFAMM00433308 Functional Category Bioactive
Superfamily Histamine H3 receptor and C-C chemokine receptor type 5 Binder Superfamily
Class Class 3039

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand be... 4 301
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Tubulin beta chain Inhibitor Mebendazole Family 12 84
Histamine H1 receptor Ligand Mizolastine Family 14 603
Prothrombin Inhibitor Dabigatran Family 7 182
BIBT986 family 7 96
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Telomerase reverse transcriptase Inhibitor HOE-33258 Family 10 33
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 8 12
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Melanin-concentrating hormone receptor 1 ligand AGN-PC-088XRP ... 2 10
Lysosomal Pro-X carboxypeptidase inhibitor 2-amino-N-[(2S)-1-[... 11 16
Lysosomal Pro-X carboxypeptidase inhibitor (2S,3S)-2-[(2-amino... 3 0
C-C chemokine receptor type 5 ligand SureCN1573831 family 4 3
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 9 10
Bile acid receptor and Potassium voltage-gated channel subfami... 2 1
Substance-P receptor and Substance-K receptor ligand 3,5-dichl... 3 1
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 7
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
C-C chemokine receptor type 5 ligand methyl N-cyano-4-[2-[(1R,... 8 8
C-C chemokine receptor type 5 ligand [4-[2-[3-(2-ethylbenzimid... 5 12
D(3) dopamine receptor and D(2) dopamine receptor ligand N-[(E... 1 0
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 7 1
Histamine H3 receptor ligand SureCN2878688 family 8 1
Histamine H1 receptor and Histamine H4 receptor ligand [4-[2-[... 1 1
Coagulation factor X inhibitor SureCN8289965 family 4 5
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 4 1
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Transient receptor potential cation channel subfamily V member... 1 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Mitogen-activated protein kinase 8 inhibitor 4-[(6-chloro-1-ox... 1 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Substance-P receptor and Substance-K receptor ligand 2-[3-[1-[... 10 0
Substance-K receptor and Substance-P receptor ligand 3,5-dichl... 3 0
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase Chk1 inhibitor CHIR-124 family 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
C-C chemokine receptor type 5 ligand 1-[4-(3-chlorophenyl)-4-[... 3 1
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-077RDJ family 15 1
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Melanin-concentrating hormone receptor 1 ligand SureCN3832854 ... 3 2
Pteridine reductase, putative inhibitor 1-[(3,4-dichlorophenyl... 2 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Neuropeptide Y receptor type 5 ligand SureCN8149543 family 1 0
Substance-K receptor ligand AGN-PC-074GCM family 2 2


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433301 CHEMBL74127 Bioactive AGN-PC-074GBZ
CFAMM00433300 CHEMBL305236 Bioactive AGN-PC-074GC9
CFAMM00433306 CHEMBL71394 Bioactive AGN-PC-074GBD
CFAMM00433299 CHEMBL71226 Bioactive AGN-PC-074GEF
CFAMM00433309 CHEMBL75422 Bioactive 3,5-dichloro-N-[(2Z,3R)-3-(3,4-dichlorophenyl)-2-methoxyimino-5-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]pentyl]-N-methylbenzamide
CFAMM00433302 CHEMBL304807 Bioactive AGN-PC-074GC8
CFAMM00433308 CHEMBL68440 Bioactive SureCN9035669

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

42930 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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