CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15322
Family Name Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylsulfanylbutanoic acid family
No. of Seeds 5 No. of Other Members 3
Family Centroid CFAMM00433368 Functional Category Bioactive with Natural Product
Superfamily Prothrombin and Endothelin-1 receptor Binder Superfamily
Class Class 877

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(2) dopamine receptor ligand ergot alkaloid Cabergoline Family 5 74
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
Histone deacetylase 1 Inhibitor Panobinostat Family 5 93
CBP-501 family 7 8
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Neuropeptide Y receptor type 5 Ligand Npy5ra-972 Family 6 29
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Cyclin-dependent kinase 1 and G2/mitotic-specific cyclin-B1 In... 2 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Acetylcholinesterase and Cholinesterase Inhibitor 3-(2-diethyl... 12 160
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Integrin beta-3 and Integrin alpha-V inhibitor SureCN3888804 f... 11 13
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Caspase-1 inhibitor (3S)-3-[[(2S)-4-[2-(1,2-dimethylindol-3-yl... 3 4
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 11 20
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
5-hydroxytryptamine receptor 1A ligand 2-[4-(quinolin-2-ylmeth... 2 91
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
cGMP-specific 3',5'-cyclic phosphodiesterase and Dual 3',5'-cy... 4 129
Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Cannabinoid receptor 2 ligand 1-[[4-[5-fluoro-6-(piperidin-1-y... 21 2
Adenosine receptor A2b and Adenosine receptor A2a ligand N-(4-... 2 14
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(1-cyanocyclop... 10 7
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Protein kinase C delta type and Protein kinase C beta type inh... 4 4
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Platelet-activating factor receptor ligand N,N-diethyl-3-[(4R)... 11 0
Tyrosine-protein kinase Yes and Proto-oncogene tyrosine-protei... 1 0
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Platelet-activating factor receptor ligand (4R)-N-(3-benzoylph... 2 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 3 1
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL3... 1 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 48


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433366 CHEMBL72891 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-propylsulfanylpropanoic acid
CFAMM00433365 CHEMBL305524 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-ethylsulfanylpropanoic acid
CFAMM00433376 CHEMBL307936 Bioactive 2-[[(2R)-2-[[2-cyclopropyl-2-[[(2S,6R)-2,6-dimethylpiperidine-1-carbonyl]amino]acetyl]amino]-3-(2-methyl-1H-indol-3-yl)propanoyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00433368 CHEMBL308403 Bioactive 2-[[(2R)-3-(2-bromo-1H-indol-3-yl)-2-[[2-[[(2R,6S)-2,6-dimethylpiperidine-1-carbonyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-4-methylsulfanylbutanoic acid

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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