CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15338
Family Name 72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-[(2S)-3-cyclohexyl-1-(2-morpholin-4-ylethylamino)-1-oxopropan-2-yl]-N'-hydroxy-2-[3-(4-methylphenyl)propyl]butanediamide family
No. of Seeds 10 No. of Other Members 0
Family Centroid CFAMM00228764 Functional Category Bioactive
Superfamily Prothrombin Inhibitor Ximelagatran Superfamily
Class Class 608

Cousin Family NamesSeedsMembers
Vasopressin V1a receptor Ligand Felypressin Family 12 820
Alpha-1B adrenergic receptor Ligand Lisdexamfetamine Family 14 443
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Angiotensin-converting enzyme Inhibitor Quinapril Family 3 105
Glutathione S-transferase Inhibitor Praziquantel Family 5 167
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Melanocortin receptor 4 Ligand Ro-27-3225 Family 6 52
Dipeptidyl peptidase 4 Inhibitor Denagliptin Family 24 151
72 kDa type IV collagenase Inhibitor Batimastat Family 6 52
Renin Inhibitor CP-80794 Family 16 112
Prothrombin Inhibitor Ppack Family 5 4
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
Disintegrin and metalloproteinase domain-containing protein 17... 8 7
Plasmepsin-1 Inhibitor SC-5003 Family 93 173
Neuromedin-K receptor Ligand PD-157672 Family 9 37
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Tic... 11 31
Cathepsin B and Cathepsin S Inhibitor Ac-hphe-leu-ala-leuvsme ... 17 51
Melanocortin receptor 4 and Substance-K receptor Ligand Hoo-ph... 3 19
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Aminopeptidase N Inhibitor 2-benzyl-n1-hydroxy-n3-(4-phenylbut... 5 3
Aminopeptidase N Inhibitor N1-(4-chlorobenzyl)-2-benzyl-n3-hyd... 9 86
Prolyl endopeptidase Inhibitor SUAM-1221 Family 42 47
Mu-type opioid receptor and Nociceptin receptor Ligand Nocicep... 35 5
Aminopeptidase N Inhibitor 2-cinnamamido-n4-hexyl-n1-hydroxysu... 24 8
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 3 10
Renin inhibitor (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[... 12 1
Renin inhibitor (2S,4S,5S)-N-(4-aminobutyl)-6-cyclohexyl-4-hyd... 32 2
Substance-K receptor ligand (4S)-4-amino-1-[4-(oxan-4-ylmethyl... 1 2
72 kDa type IV collagenase and Matrilysin inhibitor (2S,3R)-N-... 1 0
Renin and Cathepsin D inhibitor (2S)-N-[(2S,3R,4S)-1-cyclohexy... 13 2
Disintegrin and metalloproteinase domain-containing protein 17... 7 1
Renin inhibitor tert-butyl N-[1-[[(3S,6S,7R)-6-(cyclohexylmeth... 14 1
Growth hormone secretagogue receptor type 1 ligand (E)-5-amino... 2 2
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 1 8
Cathepsin S inhibitor SureCN7062841 family 7 7
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Peptide deformylase inhibitor (2R)-N-[(2S)-1-(4-fluorophenyl)-... 4 0
Neutrophil collagenase and Matrix metalloproteinase-9 inhibito... 6 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand (2S... 16 24
Neutrophil collagenase and Collagenase 3 inhibitor n-[[2-methy... 1 4
Muscarinic acetylcholine receptor M3 and Muscarinic acetylchol... 3 0
Dipeptidyl peptidase 4 inhibitor (3R)-4-[(3R)-3-amino-4-(2,4,5... 6 6
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 16 1
Endothelin-converting enzyme 1 and Cathepsin D inhibitor N-[(2... 6 2
C-C chemokine receptor type 5 ligand N-[(1S)-3-[4-[[2-(2,4-dic... 4 9
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Dipeptidyl peptidase 2 and Dipeptidyl peptidase 4 inhibitor (2... 3 10
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 4
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Cathepsin S inhibitor (2R)-N-[(1R)-2-[(4-chlorophenyl)methoxy]... 2 0
Cathepsin S inhibitor (2R)-N-[(3S)-1-benzyl-3-cyanopyrrolidin-... 2 1
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-2-... 6 0
Cathepsin E and Renin inhibitor (2S)-N-[2-[[(2S,3S,5S)-1-cyclo... 4 0
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 15 0
Renin and Cathepsin D inhibitor ethyl (4S)-5-cyclohexyl-2,2-di... 2 0
Renin and Cathepsin D inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-cy... 2 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 7 1
Follicle-stimulating hormone receptor ligand N-[[3-[4-[[(2S,5S... 7 0
72 kDa type IV collagenase and Stromelysin-1 inhibitor methyl ... 6 2
Renin and Cathepsin E inhibitor (2S)-N-[(2S,3S,5R)-1-cyclohexy... 1 0
Pol polyprotein inhibitor Diol-Based HIV-1 protease inhibitor ... 1 0
Renin inhibitor N-[(2S)-1-[[(2R)-1-[[(2S)-3-cyclohexyl-1-dimet... 3 1
72 kDa type IV collagenase and Disintegrin and metalloproteina... 1 13
Histone deacetylase 1 and Histone deacetylase 8 inhibitor meth... 1 3
Melanocortin receptor 4 and Melanocyte-stimulating hormone rec... 1 0
Melanocortin receptor 4 and Melanocortin receptor 3 ligand (2S... 2 0
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 3 4
Receptor tyrosine-protein kinase erbB-2 and Disintegrin and me... 1 0
Interstitial collagenase and 72 kDa type IV collagenase inhibi... 1 1
carboxamide NP (s)-n1-(1-hydrazinyl-1-oxo-3-phenylpropan-2-yl)... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433499 CHEMBL70354 Bioactive (2R)-N'-hydroxy-2-(2-methylpropyl)-N-[(2R)-1-(3-morpholin-4-ylpropylamino)-1-oxo-3-(4-phenylphenyl)propan-2-yl]butanediamide
CFAMM00433498 CHEMBL70430 Bioactive (2R)-N'-hydroxy-2-(2-methylpropyl)-N-[(2R)-1-(3-morpholin-4-ylpropylamino)-3-naphthalen-1-yl-1-oxopropan-2-yl]butanediamide
CFAMM00433497 CHEMBL68149 Bioactive (2R)-N'-hydroxy-2-(2-methylpropyl)-N-[(2R)-1-(3-morpholin-4-ylpropylamino)-3-naphthalen-2-yl-1-oxopropan-2-yl]butanediamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27260 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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