CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15341
Family Name Substance-P receptor ligand SureCN2139814 family
No. of Seeds 7 No. of Other Members 7
Family Centroid CFAMM00433526 Functional Category Bioactive with Natural Product
Superfamily Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 Binder Superfamily
Class Class 2498

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Calcium-activated potassium channel subunit alpha-1 Ligand AVE... 3 284
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Vascular endothelial growth factor receptor 2 Ligand PF-003372... 1 4
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Mu-type opioid receptor Ligand 6-(4-(2-(benzylamino)ethyl)phen... 3 27
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 14
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 11 391
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Vascular endothelial growth factor receptor 2 ligand 7-(6-acet... 2 0
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 4 14
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Cathepsin S and Cathepsin K inhibitor N-[(2S)-3-(1-methylcyclo... 2 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 0
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 2 3
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
C-C chemokine receptor type 5 ligand N-[(3R)-3-[4-[4-methoxy-N... 13 1
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
D(3) dopamine receptor ligand AGN-PC-075Z0O family 2 3
Cholinesterase and Acetylcholinesterase inhibitor 5-hydroxy-7-... 5 19
Prostaglandin D2 receptor 2 ligand 2-[1-[4-[(4-methoxybenzoyl)... 2 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sodium-dependent serotonin transporter and Alpha-1B adrenergic... 42 20
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 3
Seprase and Prolyl endopeptidase inhibitor N-[2-[(2S)-2-cyanop... 1 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 4 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Substance-P receptor ligand (4R)-N-[(2R)-1-[benzyl(methyl)amin... 1 4
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Endothelin B receptor and Endothelin-1 receptor ligand N-[(2R)... 12 3
Matrix metalloproteinase-9 and Neutrophil collagenase inhibito... 3 7
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 2 2
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
KiSS-1 receptor ligand [2-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-[[(2S... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 4 1
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 0
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 2 ... 6 1
B2 bradykinin receptor ligand 1-N,3-N-dimethyl-4-[methyl-[2-[[... 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 0
C-C chemokine receptor type 8 and Potassium voltage-gated chan... 5 1
Protein kinase C theta type and Protein kinase C delta type in... 5 4
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3
Sodium-dependent serotonin transporter inhibitor SureCN5477150... 4 1
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 3
Leucyl-cystinyl aminopeptidase inhibitor SureCN988709 family 1 14
Gamma-aminobutyric acid receptor subunit pi and Gamma-aminobut... 2 10
Bile acid receptor ligand SureCN1243717 family 1 4
Caspase-3 and Caspase-7 inhibitor (2S)-N-[(3S)-2-hydroxy-5-oxo... 4 1
ATP-binding cassette sub-family G member 2 inhibitor 5-[(4-bro... 1 1
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433525 CHEMBL72895 Bioactive 1-benzofuran-2-ylmethyl N-[(2R)-2-(1H-indol-3-ylmethyl)-4-methyl-1-oxo-1-[[(1S)-1-phenylethyl]amino]pentan-2-yl]carbamate
CFAMM00433533 CHEMBL76501 Bioactive 1-benzofuran-2-ylmethyl N-[(2R)-3-(1H-indol-3-yl)-1-oxo-1-[[(1S)-1-phenylethyl]amino]propan-2-yl]carbamate
CFAMM00433519 CHEMBL306089 Bioactive 1-benzofuran-2-ylmethyl N-[(2S)-2-(1H-indol-3-ylmethyl)-3-methoxy-1-oxo-1-[[(1S)-1-phenylethyl]amino]propan-2-yl]carbamate
CFAMM00433531 CHEMBL77684 Bioactive 1-benzofuran-2-ylmethyl N-[(2R)-2-(1H-indol-3-ylmethyl)-1-oxo-1-[[(1S)-1-phenylethyl]amino]butan-2-yl]carbamate
CFAMM00433542 CHEMBL539928 Bioactive 1-benzofuran-2-ylmethyl N-[(2S)-2-[(dimethylamino)methyl]-3-(1H-indol-3-yl)-1-oxo-1-[[(1S)-1-phenylethyl]amino]propan-2-yl]carbamate
CFAMM00433541 CHEMBL76455 Bioactive 1-benzofuran-2-ylmethyl N-[(2R)-2-(1H-indol-3-ylmethyl)-1-oxo-1-[[(1S)-1-phenylethyl]amino]pentan-2-yl]carbamate
CFAMM00433526 CHEMBL307488 Bioactive SureCN2139814

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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