CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15364
Family Name Pol polyprotein inhibitor [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2-methylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate family
No. of Seeds 11 No. of Other Members 0
Family Centroid CFAMM00433671 Functional Category Bioactive
Superfamily Pol polyprotein and Cathepsin B Binder Superfamily
Class Class 134

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV-1 protease Inhibitor Atazanavir Family 16 58
CP-18770 family 6 27
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Renin and Pepsin A inhibitor [(2S)-1-[[(2R)-1-[[(2S,3R)-1-cycl... 2 2
Cruzipain and Cathepsin L1 inhibitor pyridin-3-ylmethyl N-[(2S... 7 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0
Pol polyprotein inhibitor AC1LAHRX family 4 0
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347937 family 4 1
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433673 CHEMBL308410 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2-ethylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433672 CHEMBL419072 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2,6-dimethylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433678 CHEMBL306772 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[[2,6-di(propan-2-yl)pyridin-4-yl]methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433671 CHEMBL307091 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2-methylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433677 CHEMBL55586 Bioactive L-738,872
CFAMM00433670 CHEMBL72385 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2,6-diethylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433676 CHEMBL72399 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2-propylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433669 CHEMBL75310 Bioactive AC1LA6QA
CFAMM00433675 CHEMBL307966 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-4-[(2-butan-2-ylpyridin-4-yl)methyl]-2-(tert-butylcarbamoyl)piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433668 CHEMBL72497 Bioactive [(2R,3R)-1,1-dioxo-2-propan-2-ylthiolan-3-yl] N-[(2S,3R)-4-[(2S)-2-(tert-butylcarbamoyl)-4-[(2,6-dibutylpyridin-4-yl)methyl]piperazin-1-yl]-3-hydroxy-1-phenylbutan-2-yl]carbamate
CFAMM00433674 CHEMBL72487 Bioactive AC1LA6Q4

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543