CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15369
Family Name Endothelin B receptor and Endothelin-1 receptor ligand N-[(2R)-1-[[(2S)-1-(butylsulfonylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide family
No. of Seeds 12 No. of Other Members 3
Family Centroid CFAMM00433699 Functional Category Bioactive with Natural Product
Superfamily Beta-lactamase and Substance-P receptor Binder Superfamily 2
Class Class 647

Cousin Family NamesSeedsMembers
Gastrin/cholecystokinin type B receptor ligand oligopeptide Ce... 35 209
Somatostatin receptor type 2 ligand octapeptide Lanreotide Family 93 156
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Tyrosine-protein phosphatase non-receptor type 1 Ligand 6-(oxa... 1 5
Serine/threonine-protein kinase Chk1 Inhibitor A-432411 Family 4 70
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Endothelin B receptor Ligand IRL-2500 Family 34 87
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Somatostatin receptor type 1 and Somatostatin receptor type 2 ... 46 0
Prostaglandin E2 receptor EP3 subtype and Prostaglandin F2-alp... 5 4
Prostaglandin E2 receptor EP3 subtype ligand AGN-PC-07Z9FK family 2 1
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-3-... 8 3
Renin and Potassium voltage-gated channel subfamily H member 2... 3 1
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand N-(1-... 3 2
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 2C lig... 3 2
Substance-P receptor ligand SureCN2139814 family 7 7
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 1 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
Angiotensin-converting enzyme and Endothelin-converting enzyme... 4 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07CPKU family 1 3
Angiotensin-converting enzyme and Collagenase 3 inhibitor (2S)... 2 1
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 1 0
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 1 3
Histone deacetylase 6 and Histone deacetylase 3 inhibitor AGN-... 2 2
Ribosomal protein S6 kinase alpha-3 inhibitor 1-oxo-N-(3-propa... 5 0


External ID

Functional Category

Molecule Name

CFAMM00433694 CHEMBL307471 Bioactive N-[(2R)-1-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-[[(E)-prop-1-enyl]sulfonylamino]propan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433700 CHEMBL308269 Bioactive N-[(2R)-1-[[(2S)-1-(benzylsulfonylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433693 CHEMBL310039 Bioactive N-[(2R)-1-[[(2S)-1-(ethenylsulfonylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433699 CHEMBL306950 Bioactive N-[(2R)-1-[[(2S)-1-(butylsulfonylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433698 CHEMBL308102 Bioactive N-[(2R)-1-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(prop-2-enylsulfonylamino)propan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433697 CHEMBL310920 Bioactive SureCN7441172
CFAMM00433705 CHEMBL73000 Bioactive N-[(2R)-1-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(propan-2-ylsulfonylamino)propan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433696 CHEMBL73373 Bioactive N-[(2R)-1-[[(2S)-1-(ethylsulfonylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433704 CHEMBL72348 Bioactive N-[(2R)-1-[[(2S)-3-(1H-indol-3-yl)-1-oxo-1-(propylsulfonylamino)propan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide
CFAMM00433701 CHEMBL72924 Bioactive N-[(2R)-1-[[(2S)-1-(2-ethoxyethylsulfonylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-[4-(1,2-oxazol-5-yl)phenyl]-1-oxopropan-2-yl]-N,3,5-trimethylbenzamide

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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