CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1538
Family Name Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-aminobutyric acid receptor subunit gamma-2 ligand 2-[4-(difluoromethoxy)phenyl]-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one family
No. of Seeds 6 No. of Other Members 5
Family Centroid CFAMM00324730 Functional Category Bioactive
Superfamily Retinal dehydrogenase 1 and Gamma-aminobutyric acid receptor subunit alpha-1 Binder Superfamily
Class Class 2747

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Hepatocyte growth factor receptor Ligand Amg 208 Family 20 236
PF-02545920 family 16 140
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
Interleukin-4 Inhibitor SIL-4R Family 2 16
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Platelet-derived growth factor receptor alpha and Platelet-der... 2 14
5-hydroxytryptamine receptor 2A Ligand [2-(6-methoxy-indol-1-y... 2 10
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
Adenosine receptor A3 Ligand 4-methoxy-2-phenyl-2h-pyrazolo[4,... 9 49
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Glucocorticoid receptor Ligand 1-(3-chloro-4-fluorophenyl)-2,2... 1 13
Metabotropic glutamate receptor 5 Ligand 3-methoxy-5-(1,5-naph... 4 20
Cannabinoid receptor 1 Ligand 1-(2-morpholinoethyl)-1h-indol-3... 8 46
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 9 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 0
Sigma non-opioid intracellular receptor 1 ligand 1'-butyl-6-me... 23 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 10
Smoothened homolog inhibitor AGN-PC-088VBV family 1 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 40
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 6
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL15681... 1 5
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Somatostatin receptor type 2 ligand SureCN4317006 family 10 1
Serine/threonine-protein kinase B-raf inhibitor AGN-PC-00CFYH ... 2 1
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 9 1
Sigma non-opioid intracellular receptor 1 ligand 6-methoxy-1'-... 2 0
Muscarinic acetylcholine receptor M3 ligand 3-fluoro-2-(3-pipe... 3 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 0
Corticotropin-releasing factor receptor 1 ligand 2-(2-ethyl-4,... 4 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 33 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
D(3) dopamine receptor and D(2) dopamine receptor ligand Piper... 3 14
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 5 14
Potassium voltage-gated channel subfamily H member 2 and 5-hyd... 2 2
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 6 4
Prostaglandin D2 receptor 2 ligand 2-[4-(difluoromethoxy)-2-et... 1 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4B inhibitor AGN-... 2 0
Serine/threonine-protein kinase Chk1 inhibitor SureCN6792758 f... 22 12
Serine/threonine-protein kinase Chk1 inhibitor SureCN4806204 f... 13 7
Serine/threonine-protein kinase Chk1 and Aurora kinase B inhib... 14 0
Prostaglandin G/H synthase 2 and Prostaglandin G/H synthase 1 ... 3 40
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 10 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
Inosine-5'-monophosphate dehydrogenase inhibitor 5-[(1R)-1-[1-... 2 9
RAC-alpha serine/threonine-protein kinase and Rho-associated p... 1 0
Glutamate receptor ionotropic, NMDA 1 ligand SureCN8971235 family 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 1
Acetylcholinesterase and Cholinesterase inhibitor P10358 family 2 0
Serine/threonine-protein kinase Chk1 inhibitor 3-[(8-chloro-3-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324725 CHEMBL326560 Bioactive 2-(4-cyclobutyloxyphenyl)-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324730 CHEMBL432623 Bioactive 2-[4-(difluoromethoxy)phenyl]-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324728 CHEMBL118053 Bioactive 2-[4-(trifluoromethoxy)phenyl]-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324734 CHEMBL297751 Bioactive 8-chloro-2-(4-methoxyphenyl)-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324727 CHEMBL446673 Bioactive 2-(4-cyclopropyloxyphenyl)-6,7,8,9-tetrahydro-1H-pyrazolo[4,3-c]quinolin-3-one
CFAMM00324726 CHEMBL173491 Bioactive 2-phenyl-8-phenylmethoxy-1H-pyrazolo[4,3-c]quinolin-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26821 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543