CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15389
Family Name Thromboxane-A synthase inhibitor 6-chloro-3-(4-imidazol-1-ylbutyl)-1H-quinazoline-2,4-dione;hydrochloride family
No. of Seeds 12 No. of Other Members 21
Family Centroid CFAMM00433822 Functional Category Bioactive with Natural Product
Superfamily Thromboxane-A synthase and Melanin-concentrating hormone receptor 1 Binder Superfamily
Class Class 96

Cousin Family NamesSeedsMembers
Reverse transcriptase Inhibitor Nevirapine Family 23 640
Prothrombin Inhibitor Dabigatran Family 7 182
Dipeptidyl peptidase 4 Inhibitor SSR-162369 Family 8 27
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor Ligand SCH79687 Family 11 29
Herpes simplex virus type 1 thymidine kinase Inhibitor 9-(4-hy... 2 13
Tubulin beta chain Inhibitor 2-(3-chloro-phenyl)-1h-[1,8]napht... 3 13
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 6-im... 2 30
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Bifunctional epoxide hydrolase 2 Inhibitor 6-amino-n-(2,4-dich... 10 116
Proto-oncogene tyrosine-protein kinase Src Inhibitor 5,7-diphe... 2 11
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Herpes simplex virus type 1 thymidine kinase Inhibitor N2-(3-t... 1 2
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Poly [ADP-ribose] polymerase 1 inhibitor 2-(3-chlorophenyl)-1H... 4 38
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Platelet-activating factor receptor ligand SureCN9523843 family 4 4
RAC-alpha serine/threonine-protein kinase inhibitor SureCN4728... 11 6
Substance-P receptor ligand (3R,4S)-N-[[3,5-bis(trifluoromethy... 3 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Coagulation factor X inhibitor AGN-PC-075AY8 family 28 21
Cell division cycle 7-related protein kinase inhibitor pyrrolo... 4 10
Vascular endothelial growth factor receptor 2 ligand AC1LLCDM ... 1 2
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
5-hydroxytryptamine receptor 4 ligand 6-chloro-N-[[1-(2-methyl... 10 19
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 4 2
Coagulation factor X inhibitor AGN-PC-078Y4E family 4 6
Prelamin-A/C inhibitor CHEMBL1503535 family 1 0
Prothrombin inhibitor AGN-PC-09QLAK family 10 2
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 2 2
Tyrosine-protein kinase ITK/TSK and Receptor-type tyrosine-pro... 1 0
Coagulation factor X inhibitor AGN-PC-078Y3A family 4 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
C-X-C chemokine receptor type 3 ligand 5-[(3S)-4-[1-(4-chlorob... 6 0
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Vascular endothelial growth factor receptor 2 ligand (3Z)-6-fl... 4 3
Cytochrome P450 11B1, mitochondrial and Cytochrome P450 11B2, ... 3 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (4-am... 2 1
Cannabinoid receptor 1 ligand N-(cyclobutylmethyl)-3-[[4-(tria... 1 0
Melanocortin receptor 4 ligand AGN-PC-076AMO family 17 8
Non-receptor tyrosine-protein kinase TYK2 ligand AGN-PC-0D0YSZ... 10 0
5-hydroxytryptamine receptor 4 and 5-hydroxytryptamine recepto... 10 1
Coagulation factor X and Prothrombin inhibitor SureCN6593603 f... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Coagulation factor X inhibitor AGN-PC-078Y0S family 7 1
Mitogen-activated protein kinase 8 inhibitor 4-[(6-chloro-1-ox... 1 1
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 5 0
Coagulation factor X inhibitor AGN-PC-078Y0T family 11 0
Collagenase 3 inhibitor 4-[[6-(3-imidazol-1-ylprop-1-ynyl)-4-o... 1 1
Cyclin-dependent kinase 2 and Potassium voltage-gated channel ... 12 7
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Sonic hedgehog protein and Cytochrome P450 2C9 inhibitor AGN-P... 1 0
Substance-K receptor ligand AGN-PC-074GCM family 2 2
Aromatase and Beta-lactamase inhibitor N-(3-Imidazol-1-yl-prop... 1 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 2
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[3-(4-fluorop... 1 0
Nonstructural protein 1 and Lysine-specific demethylase 4E inh... 2 1
Thromboxane-A synthase inhibitor AGN-PC-00OGRA family 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00433799 CHEMBL554990 Bioactive 6-chloro-3-(3-imidazol-1-yl-2-methylpropyl)-1H-quinazoline-2,4-dione;hydrochloride
CFAMM00433825 CHEMBL544065 Bioactive 7-chloro-3-(3-imidazol-1-yl-2-methylpropyl)-1H-quinazoline-2,4-dione;hydrochloride
CFAMM00433805 CHEMBL74627 Bioactive 8-chloro-3-(3-imidazol-1-yl-2-methylpropyl)-1H-quinazoline-2,4-dione
CFAMM00433818 CHEMBL74733 Bioactive 6-chloro-3-(3-imidazol-1-yl-2-methylpropyl)-1H-quinazoline-2,4-dione
CFAMM00433811 CHEMBL72684 Bioactive 6-chloro-3-(10-imidazol-1-yldecyl)-1H-quinazoline-2,4-dione
CFAMM00433817 CHEMBL309960 Bioactive 6-chloro-3-(7-imidazol-1-ylheptyl)-1H-quinazoline-2,4-dione
CFAMM00433809 CHEMBL75787 Bioactive SureCN10660769
CFAMM00433822 CHEMBL541827 Bioactive 6-chloro-3-(4-imidazol-1-ylbutyl)-1H-quinazoline-2,4-dione;hydrochloride
CFAMM00433815 CHEMBL76341 Bioactive SureCN10660798
CFAMM00433794 CHEMBL307631 Bioactive 3-(5-imidazol-1-ylpentyl)-8-(trifluoromethyl)-1H-quinazoline-2,4-dione
CFAMM00433821 CHEMBL76234 Bioactive 7-chloro-3-(3-imidazol-1-yl-2-methylpropyl)-1H-quinazoline-2,4-dione
CFAMM00433801 CHEMBL72450 Bioactive 6-chloro-3-(6-imidazol-1-ylhexyl)-1H-quinazoline-2,4-dione

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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