Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.
CFAM Family ID CFFBM15392 Family Name Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-pyrazol-1-ylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate family No. of Seeds 2
No. of Other Members 2
Family Centroid CFAMM00433835 Functional Category Bioactive
Superfamily Renin and Cytochrome P450 3A4 Binder Superfamily 2 Class Class 3541
Cousin Family Names Seeds Members HIV protease Inhibitor Indinavir Family 36 211 HIV protease Inhibitor Saquinavir Family 64 428 Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172 HIV-1 protease Inhibitor Atazanavir Family 16 58 Renin Inhibitor Remikiren Family 100 126 Bacterial outer membrane Inhibitor Daptomycin Family 6 50 CP-18770 family 6 27 Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117 Lethal factor Inhibitor GM6001 Family 50 435 Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54 Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12 Endothelin B receptor Ligand IRL-2500 Family 34 87 Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19 Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7 Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0 Pol polyprotein inhibitor AC1LAD48 family 19 5 Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8 Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4 Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5 Pol polyprotein inhibitor N-[3-[[(4R,5R,6R)-4-benzyl-5-hydroxy... 1 0 Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0 C-C chemokine receptor type 1 ligand N-[(2S,3S,5R)-5-carbamoyl... 10 4 Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3 Interstitial collagenase and Matrilysin inhibitor (2S,3R)-N,2-... 3 1 Disintegrin and metalloproteinase domain-containing protein 17... 8 4 Disintegrin and metalloproteinase domain-containing protein 17... 2 3 Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4 Pol polyprotein inhibitor (2R,3R,4R,5S)-5-[[(2S)-2-[5-[(4R,6aS... 1 0 Pol polyprotein inhibitor AC1LAHQ9 family 8 15 Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5 Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0 Renin inhibitor (2S,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-d... 3 0 Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0 Pol polyprotein inhibitor Cyclic Urea 68 family 4 0 Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0 Pol polyprotein inhibitor 183854-15-1 family 3 0 Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1 Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0 Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 3 0 Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00433835 CHEMBL307704 Bioactive
tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-pyrazol-1-ylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]carbamate CFAMM00433832 CHEMBL335338 Bioactive
(2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-pyrazol-1-ylpropan-2-yl]-N'-methyl-N'-(2-pyridin-2-ylethyl)butanediamide
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00433833 CHEMBL336932 Bioactive
(2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-1-oxo-3-pyrazol-1-ylpropan-2-yl]-4-(4-methylpiperazin-1-yl)-4-oxobutanamide CFAMM00433834 53778246 Patent Compound
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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