CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15429
Family Name Cholecystokinin receptor type A and Gastrin/cholecystokinin type B receptor ligand N-tert-butyl-2-[(3S,5S,7R)-3-[(3-methylphenyl)carbamoylamino]-2-oxo-5,7-diphenylazepan-1-yl]acetamide family
No. of Seeds 11 No. of Other Members 4
Family Centroid CFAMM00146122 Functional Category Bioactive
Superfamily Cholecystokinin receptor type A and Gastrin/cholecystokinin type B receptor Binder Superfamily
Class Class 1656

Cousin Family NamesSeedsMembers
Mu-type opioid receptor Ligand Fentanyl Family 9 647
Sodium channel Ligand xylidine derivative Mepivacaine Family 10 114
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 10 157
Alpha adrenergic receptor Ligand Droperidol Family 20 244
Sodium channel protein type 5 subunit alpha Ligand Procainamid... 7 291
Angiotensin-converting enzyme Inhibitor Benazepril Family 7 123
D(2) dopamine receptor ligand diphenylbutylpiperidine derivati... 43 161
5-hydroxytryptamine 2 receptor Ligand Ketanserin Family 10 253
Motilin receptor Ligand GSK962040 Family 30 457
Histone deacetylase 1 Inhibitor AN-9 Family 31 282
Serine/threonine-protein kinase mTOR Inhibitor CC-223 Family 12 135
Dual specificity mitogen-activated protein kinase kinase Inhib... 7 69
Potassium voltage-gated channel subfamily A member 5 Ligand S-... 34 206
Delta-type opioid receptor Ligand Sb 227122 Family 7 5
Integrin alpha-4 Inhibitor BIO-1211 Family 16 83
Vasopressin V2 receptor Ligand FR161282 Family 17 83
Gastrin/cholecystokinin type B receptor Ligand GV-150013 Family 2 5
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 19 186
Vasopressin V1a receptor and Vasopressin V2 receptor Ligand OP... 12 94
Proto-oncogene tyrosine-protein kinase Src Inhibitor RU83876 F... 3 51
Voltage-dependent T-type calcium channel subunit alpha-1I Liga... 9 19
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 40 87
3-oxo-5-alpha-steroid 4-dehydrogenase 1 Inhibitor 1-methyl-5-(... 6 17
Integrin beta-3 Inhibitor SB-208651 Family 9 28
Aromatase Inhibitor 3-(4-amino-phenyl)-1-methyl-pyrrolidine-2,... 4 8
Acetyl-CoA acetyltransferase, mitochondrial Inhibitor Octanoic... 4 14
Cholecystokinin receptor type A Ligand L-708474 Family 14 82
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Androgen receptor Ligand YM-175735 Family 30 129
Cannabinoid receptor 1 Ligand 1,3,5-triphenylimidazolidine-2,4... 2 17
Cholecystokinin receptor type A Ligand VL-1499 Family 12 133
Voltage-dependent T-type calcium channel subunit alpha-1H Liga... 3 26
Beta-secretase 1 and Cathepsin D Inhibitor GRL-7234 Family 17 148
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 14 110
Leukotriene A-4 hydrolase Inhibitor N5-[4-benzylphenyl]-l-glut... 2 1
Phospholipase D1 Inhibitor Halopemide Family 17 111
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 1 1
5-hydroxytryptamine receptor 7 Ligand UCM-5600 Family 15 46
Vasopressin V2 receptor Ligand VA-106483 Family 16 115
Mitogen-activated protein kinase 14 Inhibitor Dihydro-quinolin... 3 14
5-hydroxytryptamine receptor 3A Ligand 1-(biphenyl-4-yl)-3-(4-... 20 67
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 44 28
Bifunctional epoxide hydrolase 2 Inhibitor 1-phenyl-3-(1-propi... 22 183
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 12 4
5-hydroxytryptamine receptor 2A Ligand N-(1-(4-nitrobenzyl)pip... 4 6
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Leukotriene A-4 hydrolase Inhibitor SA-6541 Family 4 32
Prothrombin and Plasminogen inhibitor [(1R)-5-amino-1-[[2-[N-(... 1 0
Vasopressin V1a receptor ligand AGN-PC-074VJP family 3 1
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-07ZBI0 family 2 16
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 2 2
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 4 10
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 6 3
Nociceptin receptor and Mu-type opioid receptor ligand AGN-PC-... 5 2
Substance-P receptor ligand (2S)-2-N-[(2S)-1-[benzyl(methyl)am... 3 3
72 kDa type IV collagenase and Stromelysin-1 inhibitor [(2S)-2... 9 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-2-anil... 1 2
Cathepsin K and Cathepsin B inhibitor AGN-PC-01Z23J family 2 0
Kappa-type opioid receptor and Mu-type opioid receptor ligand ... 7 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 15 12
Melanocortin receptor 4 and Melanocortin receptor 5 ligand N-[... 16 117
Lethal factor inhibitor (2R)-2-(4-fluoro-3,5-dimethylanilino)-... 11 8
C-C chemokine receptor type 3 ligand SureCN6703027 family 2 1
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 2 inhibitor 1-... 2 8
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2R)-N-... 2 7
Calcitonin gene-related peptide type 1 receptor and Dual speci... 8 4
Substance-P receptor ligand (2S,4S)-2-N-[3-(diethylamino)propy... 2 7
Matrix metalloproteinase-9 and Stromelysin-1 inhibitor N-[(2S)... 1 1
Cathepsin K and Cathepsin L1 inhibitor 1-[(2S)-1-[[cyano(methy... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075BLN ... 2 1
Melanocortin receptor 4 and Melanocortin receptor 5 ligand AC1... 5 37
D(4) dopamine receptor ligand 1-Piperidineacetamide, 4-(2-cyan... 3 7
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 3 5
Follicle-stimulating hormone receptor ligand AGN-PC-005HER family 5 2
5-hydroxytryptamine receptor 1A ligand SureCN4244417 family 10 1
Delta-type opioid receptor and Potassium voltage-gated channel... 3 2
Baculoviral IAP repeat-containing protein 2 and E3 ubiquitin-p... 2 1
Oxytocin receptor ligand (2R)-2-[(2R,5R)-5-(2,3-dihydro-1H-ind... 2 0
Muscarinic acetylcholine receptor M2 and Muscarinic acetylchol... 5 19
Kappa-type opioid receptor ligand (2R)-6-amino-2-[[(2R)-2-[[(2... 2 1
Substance-P receptor and Potassium voltage-gated channel subfa... 5 0
Furin inhibitor N-[(2S)-1-[[(2S)-1-[[(2S)-1-(4-carbamimidoylan... 3 16
D(2) dopamine receptor and Potassium voltage-gated channel sub... 1 1
Calcitonin gene-related peptide type 1 receptor and Cytochrome... 2 17
Nociceptin receptor and Mu-type opioid receptor ligand N,N-dim... 5 4
Nociceptin receptor ligand 2-[3-[1-[(1R)-1,2-dihydroacenaphthy... 2 0
Microsomal triglyceride transfer protein large subunit inhibit... 8 1
Melanocortin receptor 4 ligand N-[(2R)-3-(4-chlorophenyl)-1-[4... 11 9
Substance-P receptor and Substance-K receptor ligand AGN-PC-07... 5 2
Angiotensin-converting enzyme inhibitor (2S)-2-[[(3R)-5-(carbo... 6 4
Cathepsin K and Cathepsin B inhibitor (1R,2R)-N-(cyanomethyl)-... 1 6
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 14 5
P2X purinoceptor 7 inhibitor 2-[3-fluoro-4-(trifluoromethyl)ph... 3 0
Melanocortin receptor 4 and Cytochrome P450 3A4 ligand 2-amino... 52 12
Receptor activity-modifying protein 1 and Calcitonin gene-rela... 2 4
Melanocortin receptor 4 ligand N-[(1S)-1-[2-[4-[(3S,4R)-4-(4-c... 26 13
C-C chemokine receptor type 1 ligand 3-[2-(carbamoylamino)phen... 2 1
Melanin-concentrating hormone receptor 1 ligand SureCN5517533 ... 2 3
C-C chemokine receptor type 2 ligand 2-amino-N-[2-[[(3R)-1-[(4... 5 1
Sodium channel protein type 9 subunit alpha ligand tert-butyl ... 2 30
5-hydroxytryptamine receptor 7 ligand 3-ethyl-3-[4-[4-(4-fluor... 3 1
Proteinase-activated receptor 1 ligand 2-[[2-[[2-[acetyl-[(E)-... 6 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 4 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 7 12
Substance-P receptor ligand N-[[3,5-bis(trifluoromethyl)phenyl... 1 0
Growth hormone secretagogue receptor type 1 ligand SureCN77944... 1 2
Gastrin/cholecystokinin type B receptor ligand AGN-PC-01ZDS6 f... 6 0
Tryptase alpha/beta-1 and Tryptase delta inhibitor SureCN75047... 4 2
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 5
Vascular endothelial growth factor receptor 2 ligand isoindoli... 1 0
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[4-[2-[... 1 0
Transient receptor potential cation channel subfamily V member... 1 1
Histone deacetylase 6 and Histone deacetylase 2 inhibitor 4-[[... 2 1
Phospholipase D1 and Phospholipase D2 inhibitor N-[(2S)-1-[4-(... 3 5
Muscarinic acetylcholine receptor M2 ligand AGN-PC-073RRB family 2 1
Neprilysin and Angiotensin-converting enzyme inhibitor 3-[(3S)... 1 0
Collagenase 3 and Interstitial collagenase inhibitor (2R,3S)-N... 1 0
Microbial collagenase inhibitor AGN-PC-00F17U family 1 1
Kappa-type opioid receptor and Delta-type opioid receptor liga... 3 1
Amyloid beta A4 protein inhibitor (2S,3R)-3-(2-methylpropyl)-N... 1 0
Cathepsin S and Cathepsin L1 inhibitor arylaminoethyl amide de... 2 4
E3 ubiquitin-protein ligase XIAP and Cytochrome P450 3A4 inhib... 2 0
Gastrin/cholecystokinin type B receptor ligand 2-[5-cyclohexyl... 2 1
Sterol O-acyltransferase 1 inhibitor SureCN7565101 family 2 10
Acyl-CoA:cholesterol acyltransferase inhibitor 1-[2,6-di(propa... 7 2
C5a anaphylatoxin chemotactic receptor 1 ligand SureCN12047568... 1 1
Acyl-CoA:cholesterol acyltransferase inhibitor N-[2,6-di(propa... 1 2
Voltage-dependent L-type calcium channel subunit alpha-1S liga... 1 0
Sterol O-acyltransferase 1 inhibitor SureCN9848375 family 1 0
Substance-P receptor ligand (2S)-2-N-[2-[(3,5-dimethylphenyl)m... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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