CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15432
Family Name Folate receptor alpha and Trifunctional purine biosynthetic protein adenosine-3 ligand (2R)-2-[[5-[2-(2-amino-4-oxo-1,6,7,8-tetrahydropyrimido[5,4-b][1,4]thiazin-6-yl)ethyl]-4-methylthiophene-2-carbonyl]amino]pentanedioic acid family
No. of Seeds 9 No. of Other Members 1
Family Centroid CFAMM00434026 Functional Category Bioactive
Superfamily Trifunctional purine biosynthetic protein adenosine-3 and Dihydrofolate reductase Binder Superfamily
Class Class 3385

Cousin Family NamesSeedsMembers
Peptide deformylase, mitochondrial inhibitor folic acid analog... 59 98
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 11
Dihydrofolate reductase and Thymidylate synthase inhibitor 2-[... 10 5
Dihydrofolate reductase and Trifunctional purine biosynthetic ... 1 6
Trifunctional purine biosynthetic protein adenosine-3 inhibito... 4 1
Dihydrofolate reductase inhibitor 2-[[4-[2-(2-amino-4-oxo-1,5,... 2 0


External ID

Functional Category

Molecule Name

CFAMM00434022 CHEMBL85871 Bioactive SureCN7607137
CFAMM00434026 CHEMBL82261 Bioactive (2R)-2-[[5-[2-(2-amino-4-oxo-1,6,7,8-tetrahydropyrimido[5,4-b][1,4]thiazin-6-yl)ethyl]-4-methylthiophene-2-carbonyl]amino]pentanedioic acid
CFAMM00434025 CHEMBL84935 Bioactive (2S)-2-[[5-[3-[(2,6-diamino-4-oxo-1H-pyrimidin-5-yl)sulfanyl]propyl]-3-methylthiophene-2-carbonyl]amino]pentanedioic acid
CFAMM00434024 CHEMBL85436 Bioactive (2R)-2-[[5-[2-(2-amino-4-oxo-1,6,7,8-tetrahydropyrimido[5,4-b][1,4]thiazin-6-yl)ethyl]thiophene-2-carbonyl]amino]pentanedioic acid
CFAMM00434023 CHEMBL82181 Bioactive 2-[[3-[2-(2-amino-4-oxo-1,6,7,8-tetrahydropyrimido[5,4-b][1,4]thiazin-6-yl)ethyl]benzoyl]amino]pentanedioic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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