CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15486
Family Name Epidermal growth factor receptor and Vascular endothelial growth factor receptor 1 ligand AGN-PC-01VAKK family
No. of Seeds 14 No. of Other Members 19
Family Centroid CFAMM00434323 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Vascular endothelial growth factor receptor 1 Binder Superfamily
Class Class 2909

Cousin Family NamesSeedsMembers
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
E7820 family 9 56
Macrophage metalloelastase Inhibitor PF-00356231 Family 5 79
Platelet-derived growth factor receptor alpha and Platelet-der... 5 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 7 16
Mitogen-activated protein kinase 14 Inhibitor 4-(2-ethyl-4-m-t... 14 41
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Dipeptidyl peptidase 1 inhibitor (2S)-2-amino-N-[(1S)-1-cyano-... 2 14
Protein kinase C theta type and Protein kinase C delta type in... 16 8
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 20
Histamine H3 receptor and Potassium voltage-gated channel subf... 6 14
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Substance-K receptor and Cytochrome P450 2D6 ligand 158848-32-... 4 4
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Sodium-dependent serotonin transporter inhibitor 3-[[(3S)-1-az... 1 1
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 9 16
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Orexin receptor type 1 and Orexin receptor type 2 ligand N-[[(... 9 5
Serine/threonine-protein kinase Chk1 inhibitor 2-(1H-indol-5-y... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand [4-[2... 6 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Histone deacetylase 1 inhibitor 5-[5-[[(2-chlorophenyl)methyla... 4 1
Cyclin-dependent kinase 5 and Cyclin-dependent kinase 5 activa... 4 4
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 4 0
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 3 4
Protein kinase C theta type and Protein kinase C delta type in... 4 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Vascular endothelial growth factor receptor 2 and Vascular end... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434323 CHEMBL79206 Bioactive AGN-PC-01VAKK
CFAMM00434322 CHEMBL421326 Bioactive AGN-PC-01VANF
CFAMM00434321 CHEMBL80540 Bioactive AGN-PC-01VAMS
CFAMM00434338 CHEMBL311111 Bioactive SureCN7119522
CFAMM00434344 CHEMBL310740 Bioactive AGN-PC-01VANJ
CFAMM00434337 CHEMBL77452 Bioactive AGN-PC-01VAQE

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45565 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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