CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15492
Family Name Epidermal growth factor receptor and Vascular endothelial growth factor receptor 1 ligand AGN-PC-01VAK1 family
No. of Seeds 7 No. of Other Members 0
Family Centroid CFAMM00163303 Functional Category Bioactive
Superfamily Epidermal growth factor receptor and Vascular endothelial growth factor receptor 1 Binder Superfamily
Class Class 2909

Cousin Family NamesSeedsMembers
D(2) dopamine receptor and D(1A) dopamine receptor ligand ergo... 12 720
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Omega 1 Benzodiazepine receptor Ligand Indiplon Family 4 25
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 15 457
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Potassium voltage-gated channel subfamily KQT member 1 Ligand ... 13 242
Reverse transcriptase Inhibitor Dapivirine Family 5 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 53
Aurora kinase A Inhibitor ABT-348 Family 20 49
E7820 family 9 56
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 37 57
PF-3758309 family 1 8
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 8 55
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Interleukin-1 receptor type 1 and Mitogen-activated protein ki... 7 151
Steroid 17-alpha-hydroxylase/17,20 lyase Inhibitor 1-(1-(4-thi... 3 36
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 1 9
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Vascular endothelial growth factor receptor 2 Ligand 3-(4-amin... 2 5
Cyclin-dependent kinase 5 Inhibitor 1-phenyl-3-(2-(pyridin-4-y... 3 53
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-ethy... 2 2
Macrophage migration inhibitory factor Inhibitor 4-iodo-6-phen... 5 4
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Poly [ADP-ribose] polymerase 1 Inhibitor N-(4-phenylthiazol-2-... 6 150
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 4 22
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-(2-(4-... 25 10
5-hydroxytryptamine receptor 1F and 5-hydroxytryptamine recept... 2 13
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Adenosine receptor A2b and Adenosine receptor A2a ligand SureC... 1 26
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-07ZB89 family 6 13
Protein kinase C theta type and Protein kinase C delta type in... 7 17
Deoxycytidine kinase inhibitor AGN-PC-07Z9B3 family 2 7
RAC-alpha serine/threonine-protein kinase and Cyclin-dependent... 2 7
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
Rho-associated protein kinase 1 inhibitor AGN-PC-04T4AX family 1 6
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 8 6
Substance-K receptor ligand 6-methyl-N-[1-[[(2S)-1-phenyl-5-(4... 3 9
Potassium voltage-gated channel subfamily H member 2 and Neuro... 2 3
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(4-acet... 4 12
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Receptor tyrosine-protein kinase erbB-2 ligand AGN-PC-07ZDR2 f... 7 33
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Neuropeptide Y receptor type 5 ligand N-[[(1S,5R)-3-(1-phenyle... 5 1
Neuropeptide Y receptor type 5 ligand 2-phenyl-1-[(1R,5S)-6-[[... 9 11
Mitogen-activated protein kinase 14 inhibitor AGN-PC-07ZXHN fa... 2 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Vascular endothelial growth factor receptor 2 and Mast/stem ce... 10 27
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 1 0
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Serine/threonine-protein kinase Chk1 inhibitor SureCN3070314 f... 16 32
Serine/threonine-protein kinase Chk1 inhibitor 2-(1-methylindo... 3 4
DNA-(apurinic or apyrimidinic site) lyase and Neuropeptide S r... 1 4
Thyroid hormone receptor beta and Ferritin light chain ligand ... 3 10
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 1
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
5-hydroxytryptamine receptor 2A and D(2) dopamine receptor lig... 2 4
Inosine-5'-monophosphate dehydrogenase and Nuclear receptor RO... 2 9
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Adenosine kinase inhibitor SureCN8183719 family 2 3
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Growth hormone secretagogue receptor type 1 and Dihydrofolate ... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 14 2
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Epidermal growth factor receptor ligand [4-(3-chloro-4-fluoroa... 2 5
Mitogen-activated protein kinase 14 inhibitor N-[4-[2-ETHYL-4-... 4 5
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Vascular endothelial growth factor receptor 2 and Platelet-der... 3 3
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Protein kinase C zeta type and Inhibitor of nuclear factor kap... 1 6
Serine/threonine-protein kinase Chk1 inhibitor 5-[5-(1-methylp... 3 2
Orexin receptor type 2 and Orexin receptor type 1 ligand (2-me... 3 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Glycogen synthase kinase-3 beta inhibitor N-[2-[4-(ethylsulfon... 2 2
D(3) dopamine receptor and D(2) dopamine receptor ligand 6-N-[... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Eukaryotic translation initiation factor 2-alpha kinase 3 and ... 5 0
Vascular endothelial growth factor receptor 2 ligand N-(1,3-Th... 4 4
Cyclin-T1 and Cyclin-dependent kinase 9 inhibitor 2-[3-(1,4-di... 3 3
NAD-dependent protein deacetylase sirtuin-2 and NAD-dependent ... 8 12
Melanocortin receptor 4 ligand AGN-PC-076ANF family 1 0
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 7 7
Glucocorticoid receptor ligand 3-[1-(4-fluorophenyl)imidazo[1,... 5 3
Glucocorticoid receptor ligand 3-(1H-indol-5-yl)-2,2-dimethyl-... 2 7
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Prostaglandin G/H synthase 2 inhibitor 4-N,4-N-diethyl-2-(4-me... 5 1
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 2 2
D(4) dopamine receptor and D(3) dopamine receptor ligand SureC... 1 0
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 3 1
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
5-hydroxytryptamine receptor 6 ligand 8-(1-pyrrolidin-3-ylpyrr... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 4 5
Histamine H4 receptor and Histamine H1 receptor ligand 6-chlor... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 20 7
Tyrosine-protein kinase ITK/TSK inhibitor AGN-PC-00A4QJ family 12 6
Protein kinase C theta type and Tyrosine-protein kinase Fyn in... 4 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
Transient receptor potential cation channel subfamily V member... 1 0
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Dipeptidyl peptidase 4 and Cytochrome P450 2D6 inhibitor AGN-P... 1 0
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck ligand... 1 0
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 5 0
Vascular endothelial growth factor receptor 2 and Insulin rece... 2 0
Adenosine receptor A2a and Adenosine receptor A1 ligand thioph... 2 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 5 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434393 CHEMBL311109 Bioactive SureCN7118450
CFAMM00434394 CHEMBL80809 Bioactive AGN-PC-01VAOP

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

45860 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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