CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15511
Family Name Neuropeptide Y receptor type 5 ligand 1-[1-(4-fluorophenyl)propan-2-yl]-1-methyl-3-(4-phenoxyphenyl)urea family
No. of Seeds 2 No. of Other Members 8
Family Centroid CFAMM00434481 Functional Category Bioactive
Superfamily Substance-K receptor Ligand MEN-14933 Superfamily
Class Class 1350

Cousin Family NamesSeedsMembers
Acyl-CoA desaturase Inhibitor Isoxyl Family 5 62
5-hydroxytryptamine receptor 1A Ligand (s)-way 100135 Family 94 975
C-C chemokine receptor type 1 Ligand BX-471 Family 10 67
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Cilost... 6 202
Alpha-1 adrenergic receptor Ligand DC-015 Family 8 25
Glucose-6-phosphate 1-dehydrogenase Inhibitor Metazamide Family 9 69
Leukotriene A-4 hydrolase Inhibitor N5-[4-(phenylmethoxy)pheny... 7 49
Leukotriene A-4 hydrolase Inhibitor N-benzyl-4-[(2r)-pyrrolidi... 6 40
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 11 20
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor Liga... 40 90
Substance-K receptor Ligand MEN-14933 Family 13 154
Cannabinoid receptor 1 Ligand N-(4-methoxyphenyl)oleamide Family 4 23
Alpha-1A adrenergic receptor and D(2) dopamine receptor Ligand... 5 49
Bifunctional epoxide hydrolase 2 Inhibitor 1-adamantan-1-yl-3-... 12 44
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 9 79
Bifunctional epoxide hydrolase 2 Inhibitor 1-(3-(3-morpholinop... 24 102
5-hydroxytryptamine receptor 1A and Sodium-dependent dopamine ... 8 41
Leukotriene A-4 hydrolase Inhibitor 1-[4-(4-iodophenoxy)phenyl... 5 18
Fatty-acid amide hydrolase 1 Inhibitor 2-fluorophenyl 4-(octyl... 15 9
Galanin receptor type 1 and Galanin receptor type 2 Ligand Gal... 55 132
Tyrosinase Inhibitor 1-(4-(benzyloxy)phenyl)-3-hydroxyurea Family 9 23
Vasopressin V2 receptor and Vasopressin V1a receptor ligand AG... 1 7
Substance-P receptor ligand N-[1-[acetyl-[(2-methoxyphenyl)met... 3 9
Cathepsin K inhibitor N-[(2S)-1-(4-methoxyanilino)propan-2-yl]... 11 10
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04UEH3 family 3 16
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 5 13
Beta-1 adrenergic receptor ligand 1-[2-[[(2S)-3-(2-cyanophenox... 10 4
D(3) dopamine receptor and D(2) dopamine receptor ligand 1-(3-... 4 6
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 6 2
Peroxisome proliferator-activated receptor gamma and Peroxisom... 2 10
C-C chemokine receptor type 3 ligand SureCN6705515 family 2 16
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-087THW family 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN2729784 family 3 9
Transient receptor potential cation channel subfamily V member... 3 15
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 3 1
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 11 12
Gastrin/cholecystokinin type B receptor ligand 1-[3-[[2-(3-met... 2 12
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-088O2I family 3 3
Potassium voltage-gated channel subfamily H member 2 and Melan... 9 4
Carbonic anhydrase 12 and Probable transmembrane carbonic anhy... 2 0
Mu-type opioid receptor and Kappa-type opioid receptor ligand ... 11 4
Gonadotropin-releasing hormone receptor ligand SureCN5756131 f... 5 7
Beta-3 adrenergic receptor and Beta-1 adrenergic receptor liga... 6 1
Cathepsin L1 and Cathepsin S inhibitor arylaminoethyl amide, 5... 4 5
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 4 19
Sphingosine 1-phosphate receptor 1 ligand 2-methoxy-N-[(4-phen... 2 23
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 6 3
Bifunctional epoxide hydrolase 2 inhibitor 1-(1-adamantyl)-3-[... 2 1
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-[(4... 10 0
Carbonic anhydrase 1 and Carbonic anhydrase 2 inhibitor [4-(2,... 2 11
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 1 0
Bifunctional epoxide hydrolase 2 inhibitor SureCN3178516 family 3 1
Bifunctional epoxide hydrolase 2 inhibitor 3-[4-[[4-(trifluoro... 5 22
Translocator protein inhibitor CHEMBL2332259 family 2 0
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 3 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-[4-[3... 2 0
Histamine H3 receptor and Histamine receptor H3 ligand 1-(3,5-... 1 0
Bifunctional epoxide hydrolase 2 inhibitor 8-(2,6-difluorobenz... 4 1
Bifunctional epoxide hydrolase 2 inhibitor 8-(2-ethylbutanoyl)... 11 0
Transient receptor potential cation channel subfamily M member... 2 13
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 20 23
C-X-C chemokine receptor type 3 ligand 1-[1-[(9-acetyl-9-azabi... 1 0
Neuropeptide Y receptor type 5 ligand 3-[4-(4-fluorophenoxy)ph... 4 0
Neuropeptide Y receptor type 5 ligand AGN-PC-01NRZ6 family 3 6
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 1 0
Melanin-concentrating hormone receptor 1 and D(2) dopamine rec... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 5 5
Histamine H3 receptor ligand AGN-PC-077MDJ family 2 1
Prostacyclin receptor ligand CAY10441 family 1 0
Histamine H3 receptor ligand AGN-PC-07ZCFA family 1 0
C-C chemokine receptor type 3 ligand SureCN6700764 family 2 2
Acyl-CoA:cholesterol acyltransferase inhibitor SureCN9818603 f... 2 2
D(2) dopamine receptor and D(3) dopamine receptor ligand 1-(3-... 2 0
Menin and Histone-lysine N-methyltransferase 2A inhibitor CHEM... 1 0
Acetylcholinesterase and Butyrylcholinesterase inhibitor AGN-P... 3 0
Acyl-CoA:cholesterol acyltransferase inhibitor [2,6-di(propan-... 1 0
4,4,6-trimethyl-1,3-dihydroimidazo[1,2-a]indol-2-one NP ZINC02... 37 0
8,10,10-trimethyl-3,4-dihydro-1H-pyrimido[1,2-a]indol-2-one NP... 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434476 CHEMBL442182 Bioactive 1-[1-(4-chlorophenyl)propan-2-yl]-1-methyl-3-(4-phenoxyphenyl)urea
CFAMM00434481 CHEMBL311552 Bioactive 1-[1-(4-fluorophenyl)propan-2-yl]-1-methyl-3-(4-phenoxyphenyl)urea

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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