CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15524
Family Name Vasopressin V2 receptor and Vasopressin V1a receptor ligand SureCN8315047 family
No. of Seeds 2 No. of Other Members 2
Family Centroid CFAMM00434544 Functional Category Bioactive with Natural Product
Superfamily Calcium-activated potassium channel subunit alpha-1 Ligand AVE0118 Superfamily
Class Class 656

Cousin Family NamesSeedsMembers
Melatonin receptor type 1A Ligand Melatonin Family 20 988
Sodium channel protein type 5 subunit alpha Ligand Dibucaine F... 2 136
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Vascular endothelial growth factor receptor 2 Ligand E 7080 Fa... 7 17
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
5-hydroxytryptamine receptor 1B Ligand GR55562 Family 3 45
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Cannabinoid receptor 2 Ligand JWH-202 Family 9 172
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Platelet-derived growth factor receptor alpha and Platelet-der... 2 13
Cannabinoid receptor 1 and Cannabinoid receptor 2 Ligand JWH-3... 14 214
Neuromedin-K receptor Ligand 3-methoxy-n',2-diphenylquinoline-... 14 33
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
Vasopressin V1a receptor and Vasopressin V2 receptor ligand (3... 4 41
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 3 28
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 8 32
Renin inhibitor SureCN1144364 family 3 15
Vascular endothelial growth factor receptor 2 and Aurora kinas... 3 3
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Renin inhibitor AGN-PC-09M9MJ family 2 23
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Cellular tumor antigen p53 and Microtubule-associated protein ... 1 15
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 3 21
Acetylcholinesterase inhibitor CHEMBL1651140 family 4 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 19
Renin inhibitor [2-(3-fluoro-2,6-dimethylphenoxy)-1-phenylpyrr... 5 12
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 5 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 2
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 19 10
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Cholinesterase and Acetylcholinesterase inhibitor 4-oxo-N-[9-(... 11 13
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Histamine H3 receptor ligand 2-[4-(1-methylpyrrole-2-carbonyl)... 3 4
Disintegrin and metalloproteinase domain-containing protein 17... 16 2
Sonic hedgehog protein inhibitor 3-methoxy-1-methyl-4-oxo-5-ph... 5 3
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 6 159
Fatty-acid amide hydrolase 1 inhibitor [3-(3-carbamoylpyrrol-1... 4 6
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 6 8
Coagulation factor X and Prothrombin inhibitor SureCN6434488 f... 3 13
Interstitial collagenase and Matrilysin inhibitor (3S,6R,7S)-N... 2 4
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-(3-me... 2 10
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 4 ligand 4-amino-5-chloro-N-[1-[8... 2 2
Mitogen-activated protein kinase 14 inhibitor SureCN4508019 fa... 1 0
Vasopressin V2 receptor and Vasopressin V1a receptor ligand Su... 1 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Vascular endothelial growth factor receptor 2 ligand (4Z)-4-[(... 3 0
Platelet-derived growth factor receptor beta and Vascular endo... 1 3
Oxysterols receptor LXR-beta ligand indole derivative, 39 family 2 0
Pol polyprotein inhibitor Phenprocoumon IndolEtCONH deriv. family 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434542 CHEMBL351019 Bioactive N-[3-methoxy-4-[9-[(4-methylpiperazin-1-yl)methyl]-6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl]phenyl]-2-phenylbenzamide
CFAMM00434544 CHEMBL312036 Bioactive SureCN8315047

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

23964 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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