CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1554
Family Name Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[1-(4-but-1-en-2-ylphenyl)ethenyl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid family
No. of Seeds 14 No. of Other Members 2
Family Centroid CFAMM00059911 Functional Category Bioactive
Superfamily Glutamate receptor ionotropic, kainate 2 ligand (2S,3S,4S)-4-[1-(4-but-1-en-2-ylphenyl)ethenyl]-3-(carboxymethyl)pyrrolidine-2-carboxylic acid Superfamily
Class Class 3396

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid B receptor Ligand Baclofen Family 5 12
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 16 374
Tyrosine 3-monooxygenase Inhibitor L-phenylalanine Family 19 144
Angiotensin-converting enzyme Inhibitor Spirapril Family 17 86
Angiotensin-converting enzyme inhibitor Dicarboxylate-containi... 7 54
ATP-sensitive inward rectifier potassium channel 10 Ligand Nat... 3 233
Bacterial outer membrane Inhibitor Polymyxin B Family 17 181
Iofolastat I-124 family 6 33
Neprilysin Inhibitor Thiorphan Family 41 68
Neuromedin-K receptor Ligand Senktide Family 15 22
Cathepsin F and Cruzipain Inhibitor WRR-99 Family 13 131
Beta-secretase 1 Inhibitor MMI-175 Family 30 137
Beta-secretase 1 Inhibitor Glu-leu-asp-leu-(choh-ch2)-ala-ala-... 15 11
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Azum... 3 10
Disks large homolog 4 Inhibitor N-(3,4-difluorophenyl)propyl-e... 3 0
Caspase-4 and Cathepsin D Inhibitor Grassystatin A Family 24 6
Endothelin-converting enzyme 1 Inhibitor PO3 2-leu-nal-o-3k Fa... 3 26
Genome polyprotein Inhibitor Acasp-glu-dif-glu-cha-cys Family 13 17
Genome polyprotein Inhibitor Acasp-glu-met-glu-cha-cys Family 3 6
Genome polyprotein Inhibitor Acdif-ile-cha-cys Family 37 96
Neprilysin inhibitor SureCN489232 family 3 9
72 kDa type IV collagenase and Stromelysin-1 inhibitor (2S,4R)... 5 8
Neprilysin inhibitor SureCN7437961 family 2 6
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 1
Glutamate receptor ionotropic, kainate 1 and Glutamate recepto... 1 1


External ID

Functional Category

Molecule Name

CFAMM00324969 CHEMBL120003 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(4-fluorophenyl)ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00324967 CHEMBL121461 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(3,5-dimethylphenyl)ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00324966 CHEMBL120785 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(4-fluoro-3-methylphenyl)ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00324965 CHEMBL431839 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(4-chlorophenyl)ethenyl]pyrrolidine-2-carboxylic acid
CFAMM00324964 CHEMBL334119 Bioactive (2S,3S,4S)-3-(carboxymethyl)-4-[1-(3,4-dimethylphenyl)ethenyl]pyrrolidine-2-carboxylic acid

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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