CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15545
Family Name Epidermal growth factor receptor and Vascular endothelial growth factor receptor 1 ligand AGN-PC-074K4O family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00434673 Functional Category Bioactive
Superfamily and Adenosine receptor A2b Binder Superfamily
Class Class 3914

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1D Ligand Rizatriptan Family 7 460
Aurora kinase B and Aurora kinase C Inhibitor SNS-314 Family 2 75
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
Cytochrome P450 26A1 Inhibitor Rambazole Family 7 77
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Aurora kinase A Inhibitor ABT-348 Family 20 49
PF-4217903 family 14 65
PF-3758309 family 1 8
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 4 22
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(thiophen... 9 66
Inhibitor of nuclear factor kappa-B kinase subunit beta Inhibi... 6 64
C-C chemokine receptor type 4 Ligand N-(4-tert-butylthiazol-2-... 3 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 6 55
Aurora kinase B and Aurora kinase A inhibitor AGN-PC-07ZBLC fa... 3 8
Mitogen-activated protein kinase 14 inhibitor 6-[3-amino-5-(2-... 4 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 2
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 10
Epidermal growth factor receptor ligand AGN-PC-07C2E2 family 7 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 5 27
Glycogen synthase kinase-3 beta and Dual specificity protein k... 4 5
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Mitogen-activated protein kinase 10 and Mitogen-activated prot... 2 18
Calcitonin gene-related peptide type 1 receptor ligand SureCN1... 2 0
Metabotropic glutamate receptor 4 and Potassium voltage-gated ... 2 15
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 7 21
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
TGF-beta receptor type-1 ligand 6-[(5E)-5-(4-methyl-3H-1,3-thi... 22 9
Adenosine receptor A2b and Adenosine receptor A3 ligand 3-[5-(... 4 2
3-phosphoinositide-dependent protein kinase 1 and MAP kinase-a... 1 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 12 7
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
TGF-beta receptor type-1 and Mitogen-activated protein kinase ... 6 4
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 9 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 3 6
Inhibitor of nuclear factor kappa-B kinase subunit beta and In... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 2 1
Epidermal growth factor receptor and Vascular endothelial grow... 14 19
Epidermal growth factor receptor and Vascular endothelial grow... 7 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Adenosine receptor A2a and Adenosine receptor A2b ligand SureC... 4 5
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 4 1
5-hydroxytryptamine receptor 3E and 5-hydroxytryptamine recept... 2 4
Corticotropin-releasing factor receptor 1 ligand 2-[1-[1-[4-ni... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434674 CHEMBL376945 Bioactive (3E)-3-[5-(4-piperidin-1-ylpiperidin-1-yl)benzimidazol-2-ylidene]-N-(1,3-thiazol-2-ylmethyl)-1,2-dihydroindazol-5-amine
CFAMM00434673 CHEMBL312818 Bioactive AGN-PC-074K4O

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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