CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15548
Family Name Mitogen-activated protein kinase 13 and Mitogen-activated protein kinase 12 inhibitor diaryl urea compound 6 family
No. of Seeds 6 No. of Other Members 6
Family Centroid CFAMM00434711 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 13 and Mitogen-activated protein kinase 12 Binder Superfamily
Class Class 3064

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Macrophage colony-stimulating factor 1 Inhibitor ABT-869 Family 8 56
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Metabotropic glutamate receptor 5 Ligand N-(1,4-diphenyl-1h-py... 3 35
Cyclin-dependent kinase 2 and Mitogen-activated protein kinase... 7 30
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2,6... 22 18
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Glycogen synthase kinase-3 beta Inhibitor N-(6-(thiophen-3-yl)... 4 3
Metabotropic glutamate receptor 5 Ligand N-(1,3-diphenyl-1h-py... 6 37
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 2 55
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 1 4
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Mitogen-activated protein kinase 14 inhibitor SureCN3632376 fa... 10 5
Mitogen-activated protein kinase 14 inhibitor AGN-PC-088VMM fa... 1 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Mitogen-activated protein kinase kinase kinase kinase 5 and Du... 1 18
Mitogen-activated protein kinase 14 inhibitor AGN-PC-00CSYM fa... 2 15
Mitogen-activated protein kinase 14 inhibitor AGN-PC-09M6OU fa... 8 7
Mitogen-activated protein kinase 14 inhibitor AGN-PC-069K8I fa... 12 3
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Casein kinase II subunit alpha inhibitor AGN-PC-0766PM family 4 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Mast/stem cell growth factor receptor Kit and Receptor-type ty... 8 3
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Tyrosine-protein kinase ABL1 and Abelson tyrosine-protein kina... 3 0
Metabotropic glutamate receptor 5 ligand 5-(4-fluorophenyl)-1,... 7 1
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Proto-oncogene tyrosine-protein kinase Src and Mast/stem cell ... 4 1
Casein kinase II subunit alpha inhibitor N-[5-[[3-cyano-7-(cyc... 9 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Adenosine receptor A3 and Adenosine receptor A1 ligand 2-pheny... 9 2
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 4 7
Mitogen-activated protein kinase 14 inhibitor SureCN294394 family 2 6
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 11 1
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-04VNKY family 1 4
Vascular endothelial growth factor receptor 2 ligand 1-[4-[3-a... 1 0
Mitogen-activated protein kinase 14 inhibitor tert-butyl N-[4-... 1 0
Mitogen-activated protein kinase 14 inhibitor 1-[5-tert-butyl-... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434710 CHEMBL578172 Bioactive SureCN12245428
CFAMM00434702 CHEMBL315059 Bioactive 1-(5-tert-butyl-2-naphthalen-2-ylpyrazol-3-yl)-3-phenylurea
CFAMM00434708 CHEMBL312873 Bioactive 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-naphthalen-1-ylurea
CFAMM00434706 CHEMBL314228 Bioactive AGN-PC-00GMWW
CFAMM00434705 CHEMBL86318 Bioactive 1-(5-tert-butyl-2-phenylpyrazol-3-yl)-3-(2,3-dimethylphenyl)urea
CFAMM00434711 CHEMBL420047 Bioactive diaryl urea compound 6

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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