CFam Chemical Families Database
BIDD Pharmainformatics Databases
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15557
Family Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor [(1S,3R,4R,4aR,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-4-(2-phenylethoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl] 2,2-dimethylbutanoate family
No. of Seeds 2 No. of Other Members 9
Family Centroid CFAMM00434784 Functional Category Bioactive with Natural Product
Superfamily 3-hydroxy-3-methylglutaryl-coenzyme A reductase Binder Superfamily 5
Class Class 789

Cousin Family NamesSeedsMembers
Acetyl-CoA carboxylase 2 Inhibitor Soraphen A Family 2 80
Collagenase 3 and Macrophage metalloelastase Inhibitor 5-(4'-c... 4 43
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R,... 2 15
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor [(1S... 1 1
3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor (4R)... 1 9


External ID

Functional Category

Molecule Name

CFAMM00434770 CHEMBL77486 Bioactive [(1S,3S,4aR,7S,8S,8aS)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-3-[(E)-3-phenylprop-1-enyl]-1,2,3,4,4a,7,8,8a-octahydronaphthalen-1-yl] (2S)-2-methylbutanoate
CFAMM00434784 CHEMBL313129 Bioactive [(1S,3R,4R,4aR,7S,8S)-8-[2-[(4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-4-(2-phenylethoxy)-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-1-yl] 2,2-dimethylbutanoate

Statistics of CFAM Database

CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.

How to cite our database

C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore

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