CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1556
Family Name Bifunctional dihydrofolate reductase-thymidylate synthase inhibitor AGN-PC-007JME family
No. of Seeds 5 No. of Other Members 45
Family Centroid CFAMM00325017 Functional Category Bioactive with Natural Product
Superfamily Sodium channel protein type 5 subunit alpha Ligand Enecadin Superfamily
Class Class 685

Cousin Family NamesSeedsMembers
Alpha-1D adrenergic receptor Ligand Terazosin Family 28 638
Peptide deformylase, mitochondrial Inhibitor Trimetrexate Family 4 311
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Peptide deformylase, mitochondrial Inhibitor Trimethoprim Family 67 482
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor Papaver... 53 741
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Receptor tyrosine-protein kinase erbB-2 Inhibitor CP-724714 Fa... 4 180
Vascular endothelial growth factor receptor 2 Ligand Cediranib... 8 38
SB1518 family 7 103
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Hemoglobin subunit alpha Inhibitor 2-[(2-methoxy-5-methylpheno... 5 48
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
Melanin-concentrating hormone receptor 1 Ligand 8-sec-butoxy-q... 30 39
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Enoyl-[acyl-carrier-protein] reductase [NADH] Inhibitor 5-hexy... 2 3
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 17 49
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
Deoxycytidine kinase inhibitor AGN-PC-07Z9GO family 10 2
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 4 2
Adenosine kinase inhibitor 5-[3-(4-methoxyphenyl)propyl]-6-[2-... 2 11
Survival motor neuron protein inhibitor CHEMBL1307497 family 1 2
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 6 9
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 3 21
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Dihydrofolate reductase inhibitor 2-bromo-N-[4-[4-[(2,4-diamin... 1 0
Alpha-1D adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Dihydrofolate reductase inhibitor 7-(3,4-dimethoxyphenyl)-6-me... 1 3
Dihydrofolate reductase inhibitor 7-(2-ethoxynaphthalen-1-yl)-... 3 2
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Growth hormone secretagogue receptor type 1 ligand SureCN63645... 1 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 3 5
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 1 0
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-amin... 4 3
Adenosine receptor A1 and Adenosine receptor A2a ligand N-[4-(... 4 0
Bifunctional dihydrofolate reductase-thymidylate synthase inhi... 2 6
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 12
Adenosine kinase inhibitor SureCN8139139 family 1 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 1 3
Adenosine receptor A2a ligand AGN-PC-077RYH family 16 5
Adenosine receptor A1 ligand BAS 00727702 family 1 4
Dual specificity protein kinase CLK4 and Dual specificity tyro... 6 2
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 4 3
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35
Transient receptor potential cation channel subfamily V member... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00324988 CHEMBL119086 Bioactive AGN-PC-0049NJ
CFAMM00325017 CHEMBL118602 Bioactive AGN-PC-007JME
CFAMM00324995 CHEMBL279948 Bioactive 5-[[3,4-bis(phenylmethoxy)phenyl]methyl]-6-methylpyrimidine-2,4-diamine
CFAMM00325000 CHEMBL120123 Bioactive 5-[(3-methoxy-4-phenylmethoxyphenyl)methyl]-6-methylpyrimidine-2,4-diamine
CFAMM00324993 CHEMBL22137 Bioactive 5-[[3,4-bis(phenylmethoxy)phenyl]methyl]-6-ethylpyrimidine-2,4-diamine

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27744 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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