CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15567
Family Name cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhibited 3',5'-cyclic phosphodiesterase A inhibitor SureCN10654013 family
No. of Seeds 16 No. of Other Members 0
Family Centroid CFAMM00434853 Functional Category Bioactive
Superfamily cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhibited 3',5'-cyclic phosphodiesterase A Binder Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Histamine H1 receptor Ligand Astemizole Family 7 240
Platelet-derived growth factor receptor Ligand CP-868596 Family 3 91
SB1518 family 7 103
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 1 and Cyclin-dependent kinase 2 Inhibi... 1 8
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Poly [ADP-ribose] polymerase 1 Inhibitor 2-(3'-methoxyphenyl) ... 9 93
Angiopoietin-1 receptor and Tyrosine-protein kinase Lck Inhibi... 3 64
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 3 23
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-(3''... 2 3
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Angiopoietin-1 receptor and Aurora kinase B ligand SureCN97387... 4 1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 9 3
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Adenosine receptor A3 and Adenosine receptor A2a ligand 4-(5-b... 2 5
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Melanocortin receptor 4 ligand AGN-PC-076AML family 3 24
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Coagulation factor X and Cationic trypsin inhibitor AGN-PC-075... 26 7
Serine/threonine-protein kinase Chk2 inhibitor SureCN3919556 f... 4 8
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 1 0
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Corticotropin-releasing factor receptor 1 ligand Pyridopyrazin... 2 1
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Glutamate receptor ionotropic, NMDA 2B and Glutamate receptor ... 4 11
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Vascular endothelial growth factor receptor 2 and Fibroblast g... 1 6
Platelet-derived growth factor receptor alpha and Vascular end... 3 1
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Glutamate receptor ionotropic, NMDA 1 and Glutamate receptor i... 11 1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Angiopoietin-1 receptor and Vascular endothelial growth factor... 2 0
Fatty acid-binding protein, adipocyte and Fatty acid-binding p... 4 4
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Collagenase 3 inhibitor 5-[4-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
Collagenase 3 inhibitor 1-[6-[4-(1H-benzimidazol-2-yl)phenoxy]... 3 0
C-X-C chemokine receptor type 3 ligand N-[(1R)-1-[1-(4-ethoxyp... 5 9
Sterol O-acyltransferase 1 inhibitor 1-[4-[2-(4,5-diphenyl-1H-... 1 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 8 13
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 3 0
5-hydroxytryptamine receptor 6 ligand 2-[(2Z)-2-[3-[(3-methoxy... 1 11
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Histone deacetylase 1 inhibitor (7S)-N-hydroxy-7-[[2-(5-methox... 1 2
Cholecystokinin receptor type A ligand AGN-PC-077L8J family 22 2
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 15 1
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Cathepsin S and Cathepsin K inhibitor 2-cyano-pyrropyrimidine,... 4 1
5-hydroxytryptamine receptor 2B ligand SureCN1299002 family 2 8
Nociceptin receptor and Delta-type opioid receptor ligand 2-[3... 2 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Platelet-derived growth factor receptor beta and Fibroblast gr... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 3 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Fatty-acid amide hydrolase 1 inhibitor bisarylimidazole deriva... 1 1
Multidrug resistance-associated protein 1 inhibitor SureCN6823... 1 0
Neuropeptide Y receptor type 5 ligand 7-methoxy-2-methyl-6-phe... 1 1
Putative NP ZINC40310254 Family 74 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00434858 CHEMBL90237 Bioactive N-cyclohexyl-N-methyl-5-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]pentanamide
CFAMM00434850 CHEMBL91224 Bioactive SureCN10657144
CFAMM00434857 CHEMBL91295 Bioactive 6-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]hexanoic acid
CFAMM00434849 CHEMBL90804 Bioactive SureCN10657566
CFAMM00434856 CHEMBL328543 Bioactive tert-butyl 4-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanoyl]piperazine-1-carboxylate
CFAMM00434855 CHEMBL313463 Bioactive SureCN7325045
CFAMM00434854 CHEMBL90168 Bioactive N-methyl-4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanamide
CFAMM00434853 CHEMBL91368 Bioactive SureCN10654013
CFAMM00434859 CHEMBL431799 Bioactive SureCN10656458
CFAMM00434852 CHEMBL89810 Bioactive ethyl 2-[4-[4-[(2-oxo-1,3-dihydroimidazo[4,5-b]quinolin-7-yl)oxy]butanoyl]piperazin-1-yl]acetate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27046 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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