CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1559
Family Name Mitogen-activated protein kinase 14 and Mitogen-activated protein kinase 13 inhibitor 6-[2-(2-chloro-4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)pyridazin-3-one family
No. of Seeds 2 No. of Other Members 21
Family Centroid CFAMM00325057 Functional Category Bioactive
Superfamily Mitogen-activated protein kinase 13 and Mitogen-activated protein kinase 14 Binder Superfamily
Class Class 181

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Histamine H1 receptor Ligand Mizolastine Family 14 603
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Prothrombin inhibitor SureCN5854779 family 4 9
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
Mitogen-activated protein kinase 14 inhibitor (E)-3-(2,6-dichl... 1 1
Peroxisome proliferator-activated receptor gamma ligand 1-[(4-... 7 29
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 8 13
Tyrosine-protein kinase JAK2 inhibitor AGN-PC-09QM1E family 8 15
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand SureC... 2 7
Melanin-concentrating hormone receptor 1 ligand SureCN3334191 ... 4 7
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Prostaglandin E2 receptor EP3 subtype ligand (E)-N-(3,4-difluo... 4 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN109149 family 8 1
P2X purinoceptor 7 inhibitor SureCN108625 family 4 1
P2X purinoceptor 7 inhibitor SureCN9931311 family 2 0
P2X purinoceptor 7 inhibitor SureCN109074 family 3 8
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 22
Substance-K receptor ligand SureCN9035669 family 10 5
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 1 4
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325047 CHEMBL325706 Bioactive 6-[2-(2,3-dichlorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)pyridazin-3-one
CFAMM00325057 CHEMBL118651 Bioactive 6-[2-(2-chloro-4-fluorophenyl)imidazo[1,2-a]pyridin-3-yl]-2-(2-methylphenyl)pyridazin-3-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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