CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15602
Family Name Glucagon receptor ligand SureCN2647807 family
No. of Seeds 3 No. of Other Members 7
Family Centroid CFAMM00435076 Functional Category Bioactive with Natural Product
Superfamily Cannabinoid receptor 1 and Glucagon receptor Binder Superfamily
Class Class 1049

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase B-raf inhibitor diaryl urea an... 12 93
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Histamine H1 receptor Ligand Astemizole Family 7 240
Corticotropin-releasing factor receptor 1 Ligand CRF-1 Antagon... 29 421
Receptor tyrosine-protein kinase erbB-2 Inhibitor TAK-285 Family 16 124
SB1518 family 7 103
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
DNA Binder Bisbenzimide (hoechst 33258) Family 4 159
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Cyclin-dependent kinase 2 Inhibitor 6-cyclohexylmethyloxy-2-(4... 2 11
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 13 22
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Methylated-DNA--protein-cysteine methyltransferase Inhibitor 6... 4 5
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
D(2) dopamine receptor and D(3) dopamine receptor Ligand [2-(1... 17 100
cGMP-inhibited 3',5'-cyclic phosphodiesterase A Inhibitor 7-et... 7 57
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Fatty-acid amide hydrolase 1 Inhibitor BMS-1 Family 5 22
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 17 69
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 3 4
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 6 35
Tyrosine-protein kinase Lck inhibitor 4-N-(2-chloro-6-methylph... 8 45
Vascular endothelial growth factor receptor 2 and Angiopoietin... 2 11
Histamine H4 receptor ligand AGN-PC-07ZG9H family 4 4
Sphingosine 1-phosphate receptor 1 and Sphingosine 1-phosphate... 7 16
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 4 18
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
D(2) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 7 5
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Su... 2 16
Heat shock protein HSP 90-alpha inhibitor 3-[2-amino-4-chloro-... 7 2
Vascular endothelial growth factor receptor 2 and Fibroblast g... 10 3
Vascular endothelial growth factor receptor 2 ligand AGN-PC-09... 5 11
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Renin inhibitor AGN-PC-09M4GD family 3 4
Casein kinase I isoform delta and Mitogen-activated protein ki... 3 18
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
Aromatase inhibitor AGN-PC-075MOK family 1 4
Melatonin receptor type 1A ligand N-[2-(5-methoxy-2-phenyl-1H-... 1 2
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
D(3) dopamine receptor and D(2) dopamine receptor ligand 2-[4-... 2 3
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Epidermal growth factor receptor ligand Pyrimido[4,5-b]indole ... 1 4
Glucagon receptor and Mitogen-activated protein kinase 14 liga... 6 5
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 9
Melanin-concentrating hormone receptor 1 ligand SureCN3334861 ... 1 3
Calmodulin-domain protein kinase 1 and Tyrosine-protein kinase... 5 5
Melatonin receptor type 1B ligand CHEMBL1802020 family 2 7
Tyrosine-protein kinase JAK2 inhibitor (2S)-1-[4-[4-[[7-(2-met... 11 27
Hepatocyte growth factor receptor ligand [3,5-dichloro-4-[4-(3... 1 1
Acyl-CoA desaturase 1 and Acyl-CoA desaturase inhibitor 2-[4-[... 2 6
Sodium-dependent serotonin transporter inhibitor SureCN6575591... 2 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 10 4
Receptor tyrosine-protein kinase erbB-2 ligand N-[3-chloro-4-(... 4 3
Receptor tyrosine-protein kinase erbB-2 ligand 2-[2-[4-[3-chlo... 4 5
Tyrosine-protein kinase JAK2 inhibitor N-[3-chloro-4-(4-methyl... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
Proto-oncogene tyrosine-protein kinase Src and Vascular endoth... 7 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 4 4
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-075YQ1 fa... 4 0
Serine/threonine-protein kinase B-raf and RAF proto-oncogene s... 1 0
Histamine H3 receptor ligand AGN-PC-075YXY family 1 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-07... 1 0
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 0
Activated CDC42 kinase 1 inhibitor 5-(2-fluorophenyl)-N-[[(2S)... 5 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Histamine H4 receptor ligand AGN-PC-00FEQJ family 2 3
Fatty-acid amide hydrolase 1 inhibitor 4-[[3-(4-chlorophenoxy)... 4 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Neuropeptide Y receptor type 5 ligand 6-ethylsulfonyl-2-(4-phe... 4 4
Receptor-type tyrosine-protein kinase FLT3 and Vascular endoth... 2 0
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Sodium-dependent noradrenaline transporter and Sodium-dependen... 2 7
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Vascular endothelial growth factor receptor 2 and Angiopoietin... 3 3
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 2
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 1 2
Leukotriene A-4 hydrolase inhibitor AGN-PC-00EW8S family 1 2
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074EV8... 1 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 4 1
Cyclin-dependent kinase 1 inhibitor AGN-PC-075VQQ family 2 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
Vascular endothelial growth factor receptor 2 ligand 2-aminobe... 2 0
Cyclin-dependent kinase 1 and Receptor tyrosine-protein kinase... 2 3
Rho-associated protein kinase 2 inhibitor SureCN1519463 family 5 1
Oxytocin receptor and Vasopressin V1a receptor ligand AGN-PC-0... 4 3
Epidermal growth factor receptor and Receptor tyrosine-protein... 6 0
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-04UHB... 4 2
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 8
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
Acyl-CoA desaturase 1 inhibitor AGN-PC-077KJ2 family 1 0
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-07CR... 4 0
TGF-beta receptor type-1 ligand SureCN373216 family 3 14
Oxysterols receptor LXR-alpha and Oxysterols receptor LXR-beta... 7 4
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 1 0
Beta-secretase 1 and Amyloid beta A4 protein inhibitor SureCN3... 1 5
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 1 0
Potassium voltage-gated channel subfamily H member 2 and Melan... 2 1
Neuropeptide S receptor ligand 5-(4-chlorophenyl)-6-methoxy-5-... 4 0
Lysosomal Pro-X carboxypeptidase inhibitor 4-[6-[(2S)-2-(5,6-d... 2 2
Metabotropic glutamate receptor 5 ligand AGN-PC-0760YR family 1 0
Angiopoietin-1 receptor ligand 4-[4-(6-methoxynaphthalen-2-yl)... 6 4
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Corticotropin-releasing factor receptor 1 ligand N-(dicyclopro... 3 35


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435079 CHEMBL86086 Bioactive SureCN2647039
CFAMM00435076 CHEMBL315828 Bioactive SureCN2647807

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27270 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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