CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15638
Family Name Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ligand (4R)-N-[3-[4-(2-cyanophenyl)piperidin-1-yl]propyl]-4-(3,4-difluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxamide family
No. of Seeds 20 No. of Other Members 2
Family Centroid CFAMM00243513 Functional Category Bioactive with Natural Product
Superfamily Alpha-1A adrenergic receptor and Histamine H1 receptor Binder Superfamily
Class Class 1635

Cousin Family NamesSeedsMembers
Microsomal triglyceride transfer protein large subunit Inhibit... 15 208
Dipeptidyl peptidase 4 Inhibitor Alogliptin Family 6 25
5-hydroxytryptamine receptor 2A Ligand N-(1-(1-phenylethyl)pip... 22 207
Sodium- and chloride-dependent glycine transporter 1 Inhibitor... 11 67
Hemagglutinin Inhibitor Cl 385319 Family 18 101
Beta-secretase 1 Inhibitor N-(1-benzylpiperidin-4-yl)-4-sulfan... 7 62
Alpha-1A adrenergic receptor Ligand SNAP-6201 Family 41 94
Cathepsin K and Cathepsin L1 Inhibitor N-benzoyl-phenylalanyl-... 13 77
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondria... 2 3
Phospholipase D1 Inhibitor Halopemide Family 17 111
Muscarinic acetylcholine receptor M4 and Muscarinic acetylchol... 20 55
Aminopeptidase N Inhibitor N1,2-dibenzyl-n3-hydroxymalonamide ... 5 23
Muscarinic acetylcholine receptor M1 and Muscarinic acetylchol... 9 66
Sodium channel protein type 1 subunit alpha and Sodium channel... 4 31
C-C chemokine receptor type 5 ligand 1-[1-[[(3S,4R)-1-(cyclope... 7 13
Neutrophil elastase inhibitor SureCN7423499 family 5 1
Dipeptidyl peptidase 4 inhibitor SureCN3392451 family 3 2
Dipeptidyl peptidase 4 inhibitor SureCN389715 family 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 10 0
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 9 21
Dipeptidyl peptidase 8 inhibitor (2S)-2-amino-4-[4-[bis(4-fluo... 2 9
Gonadotropin-releasing hormone receptor ligand 3-[(2R)-2-amino... 3 1
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 7 8
Sigma non-opioid intracellular receptor 1 ligand 2-(3-bromophe... 5 1
Substance-P receptor ligand (3S,4S)-N-[[3,5-bis(trifluoromethy... 8 9
Oxytocin receptor and Vasopressin V2 receptor ligand (2R)-2-(2... 4 2
Substance-P receptor ligand (3R,4R)-1-(1-acetylpiperidine-4-ca... 9 1
Dipeptidyl peptidase 4 inhibitor 2-[[4-[(3R)-3-aminopiperidin-... 1 3
Glucocorticoid receptor ligand 5-[(3-methylphenyl)methyl]-6-(4... 4 5
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor SureC... 3 8
Glucocorticoid receptor and Mineralocorticoid receptor ligand ... 5 7
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 3 1
Alpha-1A adrenergic receptor and Histamine H1 receptor ligand ... 13 1
Substance-P receptor and Potassium voltage-gated channel subfa... 5 1
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435309 CHEMBL91403 Bioactive (6R)-N-[3-[4-cyano-4-(2-cyano-4-fluorophenyl)piperidin-1-yl]propyl]-6-(3,4-difluorophenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxamide
CFAMM00435307 CHEMBL89965 Bioactive (6R)-N-[3-[4-cyano-4-(4-fluorophenyl)piperidin-1-yl]propyl]-6-(3,4-difluorophenyl)-3,4-dimethyl-2-oxo-1,6-dihydropyrimidine-5-carboxamide

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27261 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543