CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1564
Family Name Vascular endothelial growth factor receptor 2 ligand indolyl quinolinone deriv. 8 family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00325119 Functional Category Bioactive
Superfamily Proteinase-activated receptor 1 and Vascular endothelial growth factor receptor 2 Binder Superfamily
Class Class 2321

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand monosubstituted indole derivat... 14 475
Melatonin receptor type 1A Ligand Melatonin Family 20 988
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
Phospholipase A2 Inhibitor Quinacrine Family 13 95
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Nicotinic acetylcholine receptor alpha2 / alpha3 Ligand Ibogai... 3 21
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Protein kinase C theta type Inhibitor 4-(1h-indol-5-yloxy)-5-s... 21 194
5-hydroxytryptamine receptor 3B and 5-hydroxytryptamine recept... 11 41
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Oestrogen receptor and Estrogen receptor beta Ligand Pipendoxi... 11 48
D(2) dopamine receptor Ligand SLV-314 Family 19 69
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
5-hydroxytryptamine receptor 2A and Amine oxidase [flavin-cont... 4 32
D(2) dopamine receptor and D(3) dopamine receptor Ligand D-366... 5 75
5-hydroxytryptamine receptor 2A and Alpha-2A adrenergic recept... 4 29
Arachidonate 5-lipoxygenase Inhibitor TZI-41127 Family 7 34
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 16
Kinesin-like protein KIF11 inhibitor AGN-PC-080PZM family 1 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Leukotriene B4 receptor 1 and Leukotriene B4 receptor 2 ligand... 2 5
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 5
Melanin-concentrating hormone receptor 1 and Cytochrome P450 3... 8 2
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Hypoxia-inducible factor 1-alpha and Lethal factor inhibitor C... 1 1
Poly [ADP-ribose] polymerase 1 inhibitor SureCN5002485 family 2 11
Gonadotropin-releasing hormone receptor ligand AGN-PC-075RJQ f... 3 0
Matrix metalloproteinase-9 and Interstitial collagenase inhibi... 2 3
Melatonin receptor type 1A and Melatonin receptor type 1B liga... 2 0
Histone deacetylase 3 and Histone deacetylase 9 inhibitor (3S,... 1 16
Prostaglandin D2 receptor and Prostacyclin receptor ligand 2-[... 15 2
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 2 1
Thyroid hormone receptor alpha and Thyroid hormone receptor be... 2 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 16 19
Sodium-dependent serotonin transporter inhibitor SureCN7536104... 6 2
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 3 0
Translocator protein inhibitor (4S)-N,N-diethyl-9-(2-fluoranyl... 9 10
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Delta-type opioid receptor and Mu-type opioid receptor ligand ... 4 5
Cathepsin K inhibitor (1R,2R)-N-(1-cyanocyclopropyl)-2-(6-meth... 3 0
Transient receptor potential cation channel subfamily V member... 1 5
Beta-2 adrenergic receptor ligand SureCN4598646 family 7 7
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Dipeptidyl peptidase 4 and Cytochrome P450 3A4 inhibitor 6-[(3... 1 0
D(2) dopamine receptor and D(4) dopamine receptor ligand AGN-P... 1 0
Gonadotropin-releasing hormone receptor ligand SureCN7905635 f... 2 2
Histone deacetylase 3 and Histone deacetylase 9 inhibitor AGN-... 4 20
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 2
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
Substance-P receptor ligand AGN-PC-00FIT5 family 3 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 23 5
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 18 0
5-hydroxytryptamine receptor 1A and 5-hydroxytryptamine recept... 18 0
Signal transducer and activator of transcription 1-alpha/beta ... 1 36
Dipeptidyl peptidase 4 inhibitor 2-[3-(aminomethyl)-4-(4-fluor... 3 0
Kinesin-like protein KIF11 inhibitor AGN-PC-07R5ZC family 1 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325117 CHEMBL119276 Bioactive indolyl quinolinone deriv. 7
CFAMM00325119 CHEMBL118748 Bioactive indolyl quinolinone deriv. 8

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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