CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15655
Family Name Platelet-activating factor receptor ligand SureCN9853140 family
No. of Seeds 3 No. of Other Members 3
Family Centroid CFAMM00435389 Functional Category Bioactive
Superfamily Platelet-activating factor receptor and Histamine H3 receptor Binder Superfamily
Class Class 1491

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 2C ligand Tetracyclic antidepress... 14 498
CGMP-inhibited 3',5'-cyclic phosphodiesterase Inhibitor Amrino... 3 55
Nicotinic acetylcholine receptor Ligand Nicotine Family 14 686
Muscarinic acetylcholine receptor M4 Ligand Tropicamide Family 3 73
Cytochrome P450 11B1, mitochondrial Inhibitor Metyrapone Family 9 243
Sodium channel protein type 5 subunit alpha Ligand Disopyramid... 4 352
HIV-1 protease Inhibitor Atazanavir Family 16 58
Histamine H1 receptor Ligand Pheniramine Family 10 380
Histamine H1 receptor Ligand Triprolidine Family 19 316
26S proteasome Inhibitor Bortezomib Family 7 65
SUR2-type K(ATP) channel Ligand Nicorandil Family 5 85
Prothrombin Inhibitor Ximelegatran Family 8 157
Transient receptor potential cation channel subfamily V member... 15 158
Transient receptor potential cation channel subfamily V member... 16 295
Calcitonin gene-related peptide type 1 receptor Ligand Telcage... 25 124
Mitogen-activated protein kinase 14 Inhibitor Losmapimod Family 5 154
Coagulation factor X Inhibitor Otamixaban Family 9 21
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
D(3) dopamine receptor Ligand SB-277011 Family 13 178
Substance-P receptor Ligand TAK-637 Family 18 63
Amg 423 family 7 47
ABC294640 family 5 75
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Dipeptidyl peptidase 4 Inhibitor Nvp-dpp728 Family 11 42
Lethal factor Inhibitor GM6001 Family 50 435
cGMP-dependent 3',5'-cyclic phosphodiesterase Inhibitor CP-461... 4 34
Class II cytokine receptor Ligand IL-10 Family 7 45
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Aromatase Inhibitor Rogletimide Family 1 2
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Integrin beta-3 Inhibitor Elarofiban Family 28 45
D(2) dopamine receptor and D(3) dopamine receptor Ligand Azape... 7 102
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Histone deacetylase 1 and Histone deacetylase 2 Inhibitor N-(4... 4 21
Alpha-1A adrenergic receptor Ligand L-771688 Family 8 14
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 3-... 14 22
DNA-dependent protein kinase catalytic subunit Inhibitor 2-mor... 2 6
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 13 26
Transient receptor potential cation channel subfamily V member... 6 23
D(4) dopamine receptor Ligand ABT-670 Family 4 14
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cannabinoid receptor 1 Ligand N-phenyl-5,6-dip-tolylpyrazine-2... 11 26
C-C chemokine receptor type 5 Ligand GT-1282 Family 21 14
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 4 6
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Bifunctional epoxide hydrolase 2 Inhibitor N-(3,3-diphenyl-pro... 6 14
Hydroxycarboxylic acid receptor 2 Ligand 2-(6-phenylhexyl)pyri... 4 11
Kappa-type opioid receptor and Mu-type opioid receptor Ligand ... 19 108
Acetylcholinesterase and Cholinesterase Inhibitor 1,9-bis(pyri... 8 38
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Steroid 17-alpha-hydroxylase/17,20 lyase and Cytochrome P450 1... 2 4
Sodium channel protein type 10 subunit alpha Ligand N-benzyl-5... 11 46
Ribosyldihydronicotinamide dehydrogenase [quinone] Inhibitor N... 6 10
Cytochrome P450 11B1, mitochondrial Inhibitor 2-methyl-1,2-di-... 8 15
Glutamate receptor 1 Ligand Piriqualone Family 8 67
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Metabotropic glutamate receptor 5 Ligand 3-m-tolyl-1,5-naphthy... 6 10
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Metabotropic glutamate receptor 5 Ligand 5-((6-methylpyridin-2... 14 22
Sodium-dependent dopamine transporter Inhibitor (+/-)-threo-n-... 4 12
Acetylcholinesterase and Cholinesterase Inhibitor Huprine-tacr... 62 27
Choline kinase alpha Inhibitor Bisquinolinium Derivative Family 10 7
Pol polyprotein inhibitor AC1LAD48 family 19 5
Dipeptidyl peptidase 4 inhibitor (1S,3S,5S)-2-[(2S)-2-amino-2-... 3 5
Prothrombin inhibitor SureCN7371121 family 13 3
Rho-associated protein kinase 2 and cAMP-dependent protein kin... 2 7
Bifunctional epoxide hydrolase 2 and Cytochrome P450 3A4 inhib... 1 13
Histamine H3 receptor and Potassium voltage-gated channel subf... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 0
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 14 8
Muscarinic acetylcholine receptor M2 ligand AGN-PC-0745NK family 2 6
Survival motor neuron protein and Beta-lactamase inhibitor CHE... 1 0
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Histamine H3 receptor and Cytochrome P450 3A4 ligand AGN-PC-08... 15 5
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Neuronal acetylcholine receptor subunit alpha-7 and Acetylchol... 2 3
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 3 1
Histamine H3 receptor ligand AGN-PC-04YWRD family 5 13
Cathepsin K inhibitor SureCN2155973 family 3 1
Cruzipain and Cathepsin F inhibitor SureCN12999199 family 2 1
3-oxo-5-alpha-steroid 4-dehydrogenase 1 and 3-oxo-5-alpha-ster... 1 1
C-C chemokine receptor type 5 ligand AC1LA259 family 1 1
Prothrombin and Trypsin-1 inhibitor SureCN12636557 family 9 1
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 3 8
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 5 8
Platelet-activating factor receptor ligand YM-461 family 1 11
Prothrombin and Trypsin-1 inhibitor 2-[6-methyl-2-oxo-3-(2-pyr... 4 2
Dipeptidyl peptidase 4 inhibitor SureCN3389584 family 2 2
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-04SK7R family 3 3
Prothrombin inhibitor AGN-PC-09QKE4 family 1 0
Substance-K receptor ligand N-[1-[[(2R)-5-[4-(oxan-4-ylmethyl)... 2 0
Prostaglandin E synthase inhibitor AGN-PC-09QHBK family 3 1
Metabotropic glutamate receptor 5 ligand AGN-PC-0A9SVV family 2 12
Histamine H3 receptor ligand SureCN1857507 family 1 4
Smoothened homolog inhibitor (8aS)-N-[2-(3-cyanophenyl)pyridin... 3 4
Neuronal acetylcholine receptor subunit alpha-7 ligand 1-(4-me... 1 0
Neuronal acetylcholine receptor subunit alpha-7 and Neuronal a... 8 5
Oxytocin receptor ligand (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)... 20 2
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Cathepsin K and Cathepsin S inhibitor (2S)-N-(cyanomethyl)-4-m... 1 0
Histamine H3 receptor ligand (4-propan-2-yl-1,4-diazepan-1-yl)... 1 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor Di... 2 3
Probable G-protein coupled receptor 142 ligand (2S)-N-(2-oxo-5... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 7 6
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 3 2
Renin inhibitor (E)-but-2-enedioic acid;(3S,5R)-5-[4-(2-chloro... 6 8
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor SureC... 6 0
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Motilin receptor ligand SureCN2768052 family 3 0
C-C chemokine receptor type 1 ligand N-[(2R)-1-[4-(4-chlorophe... 2 1
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Histone deacetylase 1 inhibitor (2S)-N'-hydroxy-2-(pyridine-2-... 3 0
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 8 inhibitor (2... 2 2
C-C chemokine receptor type 2 and Potassium voltage-gated chan... 1 2
CGMP-dependent protein kinase inhibitor 1-[4-acetyl-3-[[4-[5-(... 2 0
Prothrombin inhibitor AGN-PC-073GVF family 12 1
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Histone deacetylase 1 inhibitor AGN-PC-0456JP family 1 0
Platelet-activating factor receptor ligand SureCN9852997 family 1 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(4-py... 9 0
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 1 1
D(4) dopamine receptor ligand SureCN4006627 family 1 0
Putative NP ZINC03999850 Family 4 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435392 CHEMBL317193 Bioactive SureCN9852878
CFAMM00435389 CHEMBL322184 Bioactive SureCN9853140
CFAMM00435388 CHEMBL545771 Bioactive AGN-PC-07C05N

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24525 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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