CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15666
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand AGN-PC-001HJH family
No. of Seeds 5 No. of Other Members 4
Family Centroid CFAMM00435439 Functional Category Bioactive
Superfamily GABA theta subunit and Cellular tumor antigen p53 Binder Superfamily
Class Class 925

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Tyrosine-protein kinase Lck and Aurora kinase B Inhibitor VX-6... 28 56
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Histamine H4 receptor Ligand A-943931 Family 14 11
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Hormone-sensitive lipase and Cholinesterase inhibitor N,N-dime... 3 3
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Adenosine receptor A2a and Adenosine receptor A2b ligand 6-(2,... 6 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
Mast/stem cell growth factor receptor Kit and Proto-oncogene t... 3 5
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A3 ligand SureCN6716937 family 1 0
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 7 0
Aurora kinase A and Glycogen synthase kinase-3 beta inhibitor ... 2 0
Aurora kinase A inhibitor SureCN2205392 family 2 2
Adenosine receptor A2b and Gamma-aminobutyric acid receptor su... 1 1
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 5


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435439 CHEMBL319966 Bioactive AGN-PC-001HJH
CFAMM00435445 CHEMBL99574 Bioactive 2-ethoxy-3H-[1,2,4]triazolo[1,5-c]quinazolin-5-one
CFAMM00435438 CHEMBL430494 Bioactive SureCN10715371
CFAMM00435442 CHEMBL317746 Bioactive AGN-PC-001HJL
CFAMM00435441 CHEMBL98848 Bioactive AGN-PC-001HJP

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27163 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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