CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15675
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand SureCN10715034 family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00435464 Functional Category Bioactive
Superfamily Reverse transcriptase/RNaseH and GABA theta subunit Binder Superfamily
Class Class 2371

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Transient receptor potential cation channel subfamily V member... 15 457
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
SCH-900776 family 8 14
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Glycogen synthase kinase-3 beta Inhibitor N-(6-(pyridin-4-yl)-... 4 23
Epidermal growth factor receptor Ligand (3-bromo-phenyl)-quina... 7 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 9 16
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 2
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Tyrosine-protein kinase JAK1 and Tyrosine-protein kinase JAK2 ... 3 12
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Tyrosine-protein kinase ABL1 and Mitogen-activated protein kin... 1 3
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Serine/threonine-protein kinase B-raf inhibitor SureCN3495829 ... 24 0
Serine/threonine-protein kinase B-raf inhibitor SureCN3495787 ... 8 1
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 2 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 11
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Vasopressin V1a receptor and Vasopressin V2 receptor ligand 8-... 6 2
Vasopressin V1a receptor ligand 2-[4-[4-[(3-chlorophenyl)methy... 1 0
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Somatostatin receptor type 5 and Somatostatin receptor type 2 ... 6 3
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Ribosomal protein S6 kinase beta-1 and RAC-alpha serine/threon... 2 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
D(4) dopamine receptor and Alpha-1D adrenergic receptor ligand... 3 3
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Cyclin-dependent kinase 2 and MAP kinase-activated protein kin... 3 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 1
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Motilin receptor ligand SureCN2004322 family 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
Cytochrome P450 3A4 and Cytochrome P450 2C8 inhibitor N-[3-[(1... 1 0
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Adenosine receptor A1 and Adenosine receptor A2b ligand SureCN... 2 3
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 2 2
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 5
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 1
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 1
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A3 ligand SureCN6716937 family 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3-[2-... 9 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 2
P2X purinoceptor 7 inhibitor 3-[[5-(2,3-dichlorophenyl)tetrazo... 2 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435465 CHEMBL318199 Bioactive [1,2,4]Triazolo[1,5-c]quinazolin-5(6H)-one, 9-chloro-2-phenyl-
CFAMM00435464 CHEMBL329502 Bioactive SureCN10715034
CFAMM00435462 CHEMBL98920 Bioactive SureCN10712253
CFAMM00435468 CHEMBL318552 Bioactive SureCN10713041

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24329 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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