CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15711
Family Name Gamma-aminobutyric acid receptor subunit pi and GABA theta subunit ligand SureCN7320174 family
No. of Seeds 5 No. of Other Members 1
Family Centroid CFAMM00435691 Functional Category Bioactive
Superfamily GABA theta subunit and Cellular tumor antigen p53 Binder Superfamily
Class Class 925

Cousin Family NamesSeedsMembers
Omega 1 Benzodiazepine receptor Ligand Zaleplon Family 6 589
Peptide deformylase, mitochondrial Inhibitor Pyrimethamine Family 10 145
Type-1 angiotensin II receptor Ligand Forasartan Family 3 253
Type-1 angiotensin II receptor Ligand Tasosartan Family 10 29
Transient receptor potential cation channel subfamily V member... 15 457
Hepatocyte growth factor receptor Ligand SGX523 Family 1 15
Interleukin-12 subunit alpha Inhibitor STA-5326 Family 2 51
HER Inhibitor AC480 Family 4 67
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
C-reactive protein Inhibitor ISIS-CRP Family 4 105
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
GDC-0349 family 44 77
PF-4217903 family 14 65
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Corticotropin-releasing factor receptor 1 Ligand Dmp-695/696 F... 11 20
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 1 9
Adenosine receptor A2a and Adenosine receptor A3 Ligand 5-buty... 3 18
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Metabotropic glutamate receptor 5 Ligand 3-(1-pyridin-2-yl-1h-... 3 6
Metabotropic glutamate receptor 5 Ligand 2-m-tolyl-1,8-naphthy... 7 11
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Histamine H4 receptor Ligand A-943931 Family 14 11
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Aurora kinase B and Tyrosine-protein kinase Lck Inhibitor CGP-... 2 29
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Type-2 angiotensin II receptor Ligand L-158809 Family 22 136
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Type-2 angiotensin II receptor Ligand SC-50560 Family 3 84
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 63
Xanthine dehydrogenase/oxidase Inhibitor 3,5-di(pyridin-4-yl)-... 6 3
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 14 4
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 8 2
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 46 9
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 4 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-074YUB... 2 0
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 6 1
Transient receptor potential cation channel subfamily V member... 1 0
Polycystin-2 and Serine/threonine-protein kinase D1 inhibitor ... 4 12
Adenosine receptor A3 and Adenosine receptor A2a ligand SureCN... 8 7
DNA-dependent protein kinase catalytic subunit and Tyrosine-pr... 2 10
Adenosine receptor A2b and Adenosine receptor A2a ligand CP-66... 3 33
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Cellular tumor antigen p53 inhibitor CHEMBL1318500 family 1 0
Adenosine receptor A2a ligand AGN-PC-077RWY family 4 5
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 7 9
Cellular tumor antigen p53 and Beta-lactamase inhibitor CHEMBL... 1 8
Prothrombin and Survival motor neuron protein inhibitor CHEMBL... 2 14
Type-1A angiotensin II receptor and Type-1B angiotensin II rec... 1 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Survival motor neuron protein and Nuclear receptor ROR-gamma l... 1 2
Nuclear receptor ROR-gamma and 15-hydroxyprostaglandin dehydro... 1 1
Survival motor neuron protein inhibitor CHEMBL1583999 family 1 3
Mitogen-activated protein kinase 13 and Mitogen-activated prot... 5 0
Prostaglandin D2 receptor ligand N-[2-(2,4-dichlorophenyl)ethy... 2 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 5-[4-... 1 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 4-met... 11 12
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Mitogen-activated protein kinase 10 and Transcription factor A... 4 4
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 2 4
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 6 7
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Adenosine receptor A3 and Adenosine receptor A1 ligand CHEMBL1... 7 4
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 1
Receptor-type tyrosine-protein kinase FLT3 and Mast/stem cell ... 2 3
Metabotropic glutamate receptor 5 ligand AGN-PC-075GBZ family 2 5
Glycogen synthase kinase-3 beta and Cyclin-dependent kinase 4 ... 2 1
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 0
Dipeptidyl peptidase 4 inhibitor Aminomethylpyrimidine 1ck family 6 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
Tyrosine-protein kinase JAK2 and Focal adhesion kinase 1 inhib... 11 3
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 2
C-C chemokine receptor type 3 ligand 1-[(1R,2S)-2-[[(3S)-3-[(4... 2 1
5-hydroxytryptamine receptor 2A and 5-hydroxytryptamine recept... 3 1
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 1 0
Vascular endothelial growth factor receptor 1 and Vascular end... 4 0
Tyrosine-protein kinase Mer and Tyrosine-protein kinase recept... 5 3
TGF-beta receptor type-1 and TGF-beta receptor type-2 ligand S... 2 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Mitogen-activated protein kinase 14 inhibitor imidazole 81 family 2 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Metabotropic glutamate receptor 2 ligand 3-(cyclopropylmethyl)... 1 1
Adenosine receptor A1 and Adenosine receptor A2a ligand AGN-PC... 4 2
Adenosine receptor A1 ligand N-butyl-5-phenyl-3-[[2-(trifluoro... 7 2
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor 2,... 4 4
Casein kinase II subunit alpha inhibitor 2pvj family 3 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 5 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
Alpha-1A adrenergic receptor and D(2) dopamine receptor ligand... 1 0
Protein kinase C theta type and Protein kinase C delta type in... 9 0
Type-1 angiotensin II receptor ligand 5-[2-[4-[[4-butyl-3-[[4-... 4 2
Motilin receptor ligand SureCN2004322 family 2 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 2 0
TGF-beta receptor type-2 and Vascular endothelial growth facto... 2 1
Tyrosine-protein kinase JAK2 inhibitor N-(3-methylphenyl)-5-(3... 2 4
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor N-met... 2 1
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 1-met... 2 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor 3,5-b... 4 6
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Corticotropin-releasing factor receptor 1 ligand SureCN7215846... 4 1
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 5 4
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 3 5
Type-1 angiotensin II receptor and Type-2 angiotensin II recep... 2 0
Corticotropin-releasing factor receptor 1 ligand 4-[7-(dipropy... 1 1
Adenosine receptor A3 ligand SureCN6716937 family 1 0
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 4-[6-... 3 3
Epidermal growth factor receptor ligand AGN-PC-073LJS family 4 0
Adenosine receptor A1 ligand 3-[(2-chlorophenyl)methyl]-N-cycl... 1 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 1 0
Type-1B angiotensin II receptor ligand SureCN9309010 family 5 1
Corticotropin-releasing factor receptor 1 ligand 8-(4-bromo-2-... 1 0
High affinity nerve growth factor receptor ligand SureCN490352... 3 0
Activated CDC42 kinase 1 inhibitor AGN-PC-078WDN family 7 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor AGN-P... 17 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand AGN-P... 1 1
Aurora kinase A inhibitor SureCN2205392 family 2 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 26 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 12 0
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435689 CHEMBL98548 Bioactive AGN-PC-001HJU
CFAMM00435688 CHEMBL319178 Bioactive SureCN9831812
CFAMM00435692 CHEMBL98815 Bioactive AGN-PC-001HJF
CFAMM00435691 CHEMBL98258 Bioactive SureCN7320174
CFAMM00435690 CHEMBL99259 Bioactive SureCN7314370

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24331 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


All rights reserved.

   
 
 
Computer-aided Drug Design
about BIDD |  databases |  software |  teaching |  research |  links

 

Department of Computational Science | National University of Singapore | Blk S17, 3 Science Drive 2, Singapore 117543