| Cousin Family Names | Seeds | Members |
|---|
| Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... | 5 | 644 |
| Benzodiazepine receptor Ligand Midazolam Family | 5 | 160 |
| Histamine H1 receptor Ligand Mizolastine Family | 14 | 603 |
| Metabotropic glutamate receptor 5 Ligand ADX-48621 Family | 15 | 444 |
| C-X-C chemokine receptor type 4 Ligand AMD-070 Family | 12 | 800 |
| Transient receptor potential cation channel subfamily V member... | 16 | 295 |
| Transient receptor potential cation channel subfamily V member... | 15 | 457 |
| Transient receptor potential cation channel subfamily V member... | 6 | 66 |
| Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... | 10 | 56 |
| Fibroblast growth factor receptor 2 and Fibroblast growth fact... | 11 | 86 |
| Cyclin-dependent kinase 4 Inhibitor PD-332991 Family | 13 | 155 |
| Cannabinoid receptor 1 Ligand AZD2207 Family | 18 | 48 |
| Cannabinoid receptor 1 Ligand CP-945598 Family | 18 | 173 |
| Translocator protein Inhibitor Emapunil Family | 7 | 89 |
| 5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... | 14 | 234 |
| Protein kinase C alpha type and Protein kinase C beta type Inh... | 16 | 86 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 35 | 270 |
| HCV NS4B protein Inhibitor Clemizole Family | 2 | 43 |
| Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... | 13 | 55 |
| RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... | 35 | 69 |
| GDC-0349 family | 44 | 77 |
| Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family | 9 | 29 |
| Class II cytokine receptor Ligand IL-10 Family | 7 | 45 |
| D(4) dopamine receptor Ligand L-745,870 Family | 30 | 205 |
| Histamine H3 receptor Ligand SCH79687 Family | 11 | 29 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 11 | 138 |
| Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... | 31 | 66 |
| Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... | 4 | 12 |
| Farnesyltransferase beta subunit, putative and Protein farnesy... | 20 | 81 |
| Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... | 18 | 109 |
| Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... | 7 | 117 |
| Epidermal growth factor receptor Ligand PD-158780 Family | 98 | 89 |
| Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... | 2 | 5 |
| Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... | 6 | 5 |
| Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... | 19 | 165 |
| Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family | 14 | 103 |
| Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... | 8 | 5 |
| RAC-gamma serine/threonine-protein kinase and Rho-associated p... | 16 | 46 |
| Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... | 7 | 51 |
| Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... | 2 | 9 |
| Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... | 3 | 9 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... | 41 | 59 |
| Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... | 8 | 11 |
| Mitogen-activated protein kinase kinase kinase 8 and Stromelys... | 6 | 53 |
| Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family | 3 | 14 |
| Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family | 4 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... | 219 | 124 |
| Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family | 5 | 6 |
| Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... | 3 | 10 |
| Sodium channel protein type 1 subunit alpha and Sodium channel... | 10 | 14 |
| Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... | 2 | 3 |
| Prothrombin inhibitor SureCN5854779 family | 4 | 9 |
| Prothrombin inhibitor SureCN5856722 family | 3 | 16 |
| Corticotropin-releasing factor receptor 1 ligand SureCN5395386... | 6 | 5 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 4 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 10 | 3 |
| Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... | 7 | 7 |
| Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... | 3 | 0 |
| Platelet-activating factor receptor ligand SureCN9384429 family | 11 | 3 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 2 | 21 |
| Platelet-activating factor receptor ligand SureCN9383514 family | 4 | 1 |
| RAF proto-oncogene serine/threonine-protein kinase and Serine/... | 3 | 5 |
| Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... | 8 | 8 |
| Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... | 5 | 4 |
| Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... | 16 | 5 |
| Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... | 6 | 9 |
| Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... | 16 | 9 |
| Melanin-concentrating hormone receptor 1 and Potassium voltage... | 8 | 27 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 7 | 10 |
| RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... | 2 | 4 |
| Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... | 4 | 19 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 1 | 0 |
| Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... | 3 | 11 |
| Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... | 1 | 0 |
| Type-1B angiotensin II receptor ligand SureCN683399 family | 3 | 0 |
| Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... | 8 | 4 |
| Protein farnesyltransferase/geranylgeranyltransferase type-1 s... | 4 | 0 |
| D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... | 13 | 8 |
| Dihydrofolate reductase and Bifunctional dihydrofolate reducta... | 5 | 0 |
| Prelamin-A/C inhibitor CHEMBL1472945 family | 1 | 32 |
| Dihydrofolate reductase inhibitor AC1LAKWV family | 2 | 0 |
| Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... | 2 | 1 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... | 5 | 0 |
| Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... | 3 | 7 |
| C-C chemokine receptor type 5 and Potassium voltage-gated chan... | 21 | 32 |
| Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family | 1 | 3 |
| Signal transducer and activator of transcription 6 inhibitor A... | 3 | 0 |
| Fatty-acid amide hydrolase 1 inhibitor 3-[(3S)-1-[4-(5-chlorot... | 2 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family | 7 | 7 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 0 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 10 | 1 |
| Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... | 2 | 2 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 2 | 0 |
| Smoothened homolog inhibitor N-[(1-morpholin-4-ylcyclopentyl)m... | 2 | 33 |
| Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... | 2 | 13 |
| Sodium-dependent serotonin transporter and 5-hydroxytryptamine... | 5 | 8 |
| Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... | 4 | 0 |
| Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... | 2 | 6 |
| cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... | 2 | 0 |
| Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... | 4 | 0 |
| Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family | 10 | 11 |
| Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family | 7 | 29 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... | 4 | 4 |
| Epidermal growth factor receptor and Receptor tyrosine-protein... | 8 | 4 |
| Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... | 3 | 1 |
| Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... | 4 | 2 |
| Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... | 4 | 5 |
| Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... | 2 | 5 |
| Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... | 5 | 0 |
| Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... | 2 | 2 |
| Transient receptor potential cation channel subfamily V member... | 4 | 0 |
| D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... | 2 | 0 |
| Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family | 2 | 2 |
| Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... | 4 | 1 |
| Substance-P receptor ligand SureCN7659714 family | 2 | 0 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 6 | 2 |
| Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... | 3 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... | 5 | 3 |
| Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... | 5 | 9 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 7 | 4 |
| Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... | 2 | 0 |
| P2X purinoceptor 7 inhibitor SureCN109432 family | 10 | 28 |
| P2X purinoceptor 7 inhibitor SureCN113576 family | 2 | 1 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 2 | 1 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 6 | 5 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 6 | 3 |
| Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... | 2 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... | 5 | 0 |
| Translocator protein inhibitor CHEMBL2331870 family | 2 | 0 |
| CGMP-dependent protein kinase inhibitor SureCN14561191 family | 4 | 0 |
| Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... | 2 | 1 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 5 | 2 |
| Mitogen-activated protein kinase 8 and Mitogen-activated prote... | 4 | 5 |
| Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... | 1 | 2 |
| Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... | 4 | 1 |
| Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... | 2 | 8 |
| Cathepsin K inhibitor SureCN4141224 family | 3 | 0 |
| Cathepsin K and Cathepsin S inhibitor SureCN4138353 family | 3 | 0 |
| Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... | 2 | 1 |
| Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... | 3 | 0 |
| RAF proto-oncogene serine/threonine-protein kinase and Serine/... | 4 | 3 |
| Nociceptin receptor and Potassium voltage-gated channel subfam... | 5 | 2 |
| Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... | 1 | 0 |
| Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... | 4 | 3 |
| Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... | 3 | 0 |
| Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family | 2 | 0 |
| Coagulation factor X inhibitor SureCN1652469 family | 2 | 1 |
| Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... | 1 | 3 |
| Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... | 2 | 1 |
| Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... | 2 | 0 |
| Corticotropin-releasing factor receptor 1 and Corticotropin-re... | 2 | 1 |
| Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... | 3 | 4 |
| Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... | 5 | 0 |
| Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... | 1 | 0 |
| Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... | 3 | 0 |
| Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... | 7 | 0 |
| Cyclin-dependent kinase 2 inhibitor SureCN3549598 family | 3 | 1 |
| Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... | 4 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-077JWI family | 7 | 1 |
| Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... | 14 | 0 |
| Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family | 9 | 14 |
| Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... | 2 | 0 |
| Mitogen-activated protein kinase 14 and Mitogen-activated prot... | 1 | 1 |
| Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... | 1 | 0 |
Statistics of CFAM Database |
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
|
How to cite our database |
|
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
|
Last update by |
|
2014.08.29
|
