CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15720
Family Name Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ligand 3-[[4-(2-chlorophenyl)piperazin-1-yl]methyl]-6-methylimidazo[1,2-c]quinazolin-5-one family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00148725 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Epidermal growth factor receptor Binder Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
Gamma-aminobutyric acid A receptor Ligand imidazopyridine deri... 5 644
Benzodiazepine receptor Ligand Midazolam Family 5 160
Histamine H1 receptor Ligand Mizolastine Family 14 603
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Transient receptor potential cation channel subfamily V member... 6 66
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cyclin-dependent kinase 4 Inhibitor PD-332991 Family 13 155
Cannabinoid receptor 1 Ligand AZD2207 Family 18 48
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Translocator protein Inhibitor Emapunil Family 7 89
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 13 55
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
GDC-0349 family 44 77
Corticotropin-releasing factor receptor 1 Ligand CP-154526 Family 9 29
Class II cytokine receptor Ligand IL-10 Family 7 45
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Epidermal growth factor receptor and Receptor tyrosine-protein... 11 138
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Serine/threonine-protein kinase B-raf Inhibitor 2-(benzylamino... 7 117
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Cyclin-dependent kinase 4 Inhibitor 1-pyridin-2-yl-3-quinolin-... 2 5
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Adenosine receptor A3 Ligand 1-benzyl-1h-1,3,4b,9-tetraaza-flu... 19 165
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Adenosine receptor A3 Ligand 1-(2-(diethylamino)quinazolin-4-y... 2 9
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Fatty-acid amide hydrolase 1 Inhibitor JNJ-1661010 Family 3 14
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Metabotropic glutamate receptor 5 Ligand 2-(3,5-dichlorophenyl... 2 3
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Corticotropin-releasing factor receptor 1 ligand SureCN5395386... 6 5
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Leukocyte tyrosine kinase receptor and ALK tyrosine kinase rec... 3 0
Platelet-activating factor receptor ligand SureCN9384429 family 11 3
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 2 21
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 3 5
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Dipeptidyl peptidase 4 and Dipeptidyl peptidase 9 inhibitor AG... 5 4
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 9
Histamine H3 receptor ligand 1-[1-[1-[(2-aminopyridin-4-yl)met... 16 9
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 7 10
RAC-alpha serine/threonine-protein kinase and Proline-rich AKT... 2 4
Mitogen-activated protein kinase 14 and LIM domain kinase 1 in... 4 19
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Cyclin-dependent kinase 4 and G1/S-specific cyclin-D1 inhibito... 3 11
Mitogen-activated protein kinase 1 and Cytochrome P450 3A4 inh... 1 0
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
D(4) dopamine receptor and D(2) dopamine receptor ligand 4-met... 13 8
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor AC1LAKWV family 2 0
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Receptor tyrosine-protein kinase erbB-2 and Epidermal growth f... 3 7
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Signal transducer and activator of transcription 6 inhibitor A... 3 0
Fatty-acid amide hydrolase 1 inhibitor 3-[(3S)-1-[4-(5-chlorot... 2 1
Fatty-acid amide hydrolase 1 inhibitor AGN-PC-0A9RCZ family 7 7
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
Fatty-acid amide hydrolase 1 inhibitor [5-(4-chlorophenyl)tria... 2 2
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 0
Smoothened homolog inhibitor N-[(1-morpholin-4-ylcyclopentyl)m... 2 33
Sonic hedgehog protein and Smoothened homolog inhibitor N-(4,4... 2 13
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 5 8
Toll-like receptor 7 ligand 4-amino-1-[[6-[(2S)-2-(pyrrolidin-... 4 0
Corticotropin-releasing factor receptor 1 ligand 8-[butyl(ethy... 2 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Bifunctional epoxide hydrolase 2 inhibitor AGN-PC-0733AC family 7 29
Transient receptor potential cation channel subfamily V member... 4 0
C-C chemokine receptor type 4 ligand [4-[4-[(2,4-dichloropheny... 4 4
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Egl nine homolog 2 and Egl nine homolog 1 inhibitor 8-[(3-meth... 3 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 4 2
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Lysine--tRNA ligase inhibitor N-[2-(2-piperazin-1-ylpyridin-4-... 5 0
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Transient receptor potential cation channel subfamily V member... 4 0
D(4) dopamine receptor and D(3) dopamine receptor ligand AGN-P... 2 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-0762YG family 2 2
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Substance-P receptor ligand SureCN7659714 family 2 0
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17d ... 5 9
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
P2X purinoceptor 7 inhibitor SureCN109432 family 10 28
P2X purinoceptor 7 inhibitor SureCN113576 family 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 6 5
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Fatty-acid amide hydrolase 1 inhibitor 4-(3-phenyl-1,2,4-thiad... 2 1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 5 0
Translocator protein inhibitor CHEMBL2331870 family 2 0
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Mitogen-activated protein kinase 8 and Mitogen-activated prote... 4 5
Serine/threonine-protein kinase PLK2 and Serine/threonine-prot... 1 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 8
Cathepsin K inhibitor SureCN4141224 family 3 0
Cathepsin K and Cathepsin S inhibitor SureCN4138353 family 3 0
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 3 0
Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family 2 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Nitric oxide synthase, inducible inhibitor N-[(4-chlorophenyl)... 2 1
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Tyrosine-protein kinase SYK and Tyrosine-protein kinase ZAP-70... 3 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Cyclin-dependent kinase 2 inhibitor SureCN3549598 family 3 1
Neuropeptide Y receptor type 5 ligand 1-methylsulfonyl-N-(2-ph... 4 0
Cannabinoid receptor 1 ligand AGN-PC-077JWI family 7 1
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Adenosine receptor A1 and Adenosine receptor A2a ligand 2-(2-c... 2 0
Mitogen-activated protein kinase 14 and Mitogen-activated prot... 1 1
Metabotropic glutamate receptor 5 ligand 2-[4-(4-fluoro-3-meth... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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