CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15734
Family Name Tyrosine-protein kinase Lck inhibitor AGN-PC-03IU3J family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00435771 Functional Category Bioactive
Superfamily Tyrosine-protein kinase Lck and Epidermal growth factor receptor Binder Superfamily
Class Class 846

Cousin Family NamesSeedsMembers
Benzodiazepine receptor Ligand Midazolam Family 5 160
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 35 270
HCV NS4B protein Inhibitor Clemizole Family 2 43
GDC-0349 family 44 77
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Prostaglandin G/H synthase 2 Inhibitor RWJ-67657 Family 3 33
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 and Dual specificity mitogen-activated p... 5 27
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 24 79
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 1 4
Aurora kinase A inhibitor AGN-PC-07ZZEH family 2 4
Corticotropin-releasing factor receptor 1 ligand SureCN5395386... 6 5
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 10 3
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 7 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor AGN-PC-... 34 11
Ephrin type-B receptor 4 ligand SureCN3289519 family 4 2
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 13 10
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Adenosine kinase inhibitor 5-[3-(3-bromophenyl)propyl]-6-[2-(6... 3 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 1 0
Epidermal growth factor receptor ligand N-[4-(3-chloro-4-fluor... 8 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Transient receptor potential cation channel subfamily V member... 4 0
Epidermal growth factor receptor and Receptor tyrosine-protein... 8 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand 2-[8-... 2 5
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Aurora kinase A and Cyclin-dependent kinase 4 inhibitor 7-cycl... 1 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 1
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Mitogen-activated protein kinase kinase kinase 8 inhibitor Sur... 11 2
CGMP-dependent protein kinase inhibitor SureCN14561191 family 4 0
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Serine/threonine-protein kinase mTOR inhibitor 1-ethyl-3-[4-[6... 4 1
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Adenosine kinase inhibitor SureCN8248615 family 2 3
Corticotropin-releasing factor receptor 1 ligand AGN-PC-00FF1P... 1 3
Proto-oncogene tyrosine-protein kinase Src and Tyrosine-protei... 3 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Tyrosine-protein kinase ITK/TSK and Insulin receptor ligand AG... 5 1
Platelet-derived growth factor receptor beta and Fibroblast gr... 10 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Cannabinoid receptor 2 ligand 4-[6-(2,3-dichlorophenyl)-1,2,4-... 1 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00435771 CHEMBL320967 Bioactive AGN-PC-03IU3J
CFAMM00435770 CHEMBL84046 Bioactive AGN-PC-03ITVR

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

26197 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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