CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15800
Family Name Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ligand N,N-dimethyl-2-[3-[4-[2-(1,3-oxazol-2-yl)phenyl]piperazin-1-yl]propylamino]pyridine-3-carboxamide family
No. of Seeds 2 No. of Other Members 6
Family Centroid CFAMM00284611 Functional Category Bioactive
Superfamily Diacylglycerol O-acyltransferase 1 and cAMP Binder Superfamily
Class Class 2433

Cousin Family NamesSeedsMembers
Serine/threonine-protein kinase PLK1 Inhibitor Bi 6727 Family 15 81
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Metabotropic glutamate receptor 1 Ligand PF-1913539 Family 130 817
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Serine/threonine-protein kinase mTOR Inhibitor INK128 Family 2 15
MK-3328 family 2 32
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
Adenosine receptor A1 and Adenosine receptor A2a Ligand CGS-15... 24 47
5-hydroxytryptamine receptor 1A Ligand P-MPPI Family 33 81
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Vascular endothelial growth factor receptor 1 and Vascular end... 4 44
Mitogen-activated protein kinase 14 Inhibitor CP-808844 Family 39 43
C-X-C chemokine receptor type 3 Ligand AMG-487 Family 28 73
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Metabotropic glutamate receptor 5 Ligand 3-methoxy-n-(6-methyl... 3 15
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 1 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor [2-[N-methy... 1 18
Adenosine receptor A2a ligand SureCN6867940 family 13 13
Receptor-type tyrosine-protein kinase FLT3 and Hepatocyte grow... 7 56
Lysine--tRNA ligase and Dual specificity protein kinase CLK4 i... 4 27
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 6 9
Bifunctional epoxide hydrolase 2 inhibitor SureCN3216677 family 4 9
Adenosine receptor A3 and Adenosine receptor A2a ligand AGN-PC... 8 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Adenosine receptor A3 and Adenosine receptor A2b ligand CHEMBL... 5 0
Survival motor neuron protein and Neuropeptide S receptor liga... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 2
Adenosine receptor A2b and Adenosine receptor A2a ligand AGN-P... 2 0
Adenosine receptor A2a ligand 5-N-[[(2R)-1-[(2-chloro-3,6-difl... 7 9
Adenosine kinase inhibitor 7-[(4aS,7aS)-6-benzyl-3,4,4a,5,7,7a... 2 1
Adenosine receptor A2a ligand 5-[[[(2R)-1-[(2-chloropyridin-4-... 5 0
Adenosine receptor A2a ligand 2-(furan-2-yl)-7-[3-[(4-phenylpi... 11 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
5-hydroxytryptamine receptor 1F ligand AGN-PC-075AYH family 2 1
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 5 12
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic ... 4 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 5
Adenosine receptor A3 ligand CHEMBL1834703 family 2 1
Vascular endothelial growth factor receptor 1 and Vascular end... 11 38
Histamine H4 receptor ligand 8-fluoro-4-[(3R)-3-(methylamino)p... 6 1
Histamine H4 receptor ligand 8-chloro-4-[(3R)-3-(methylamino)p... 1 1
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
Prothrombin inhibitor SureCN6925359 family 6 18
Prothrombin and Coagulation factor X inhibitor SureCN6929748 f... 6 5
Prothrombin and Trypsin-1 inhibitor SureCN6930543 family 10 0
Prothrombin inhibitor SureCN6931925 family 3 0
Alpha-1D adrenergic receptor and Alpha-1A adrenergic receptor ... 8 4
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
Aurora kinase A and Aurora kinase B inhibitor [4-[[7-cyclopent... 1 0
Tubulin beta-4A chain and Tubulin beta-2B chain inhibitor N-(2... 1 4
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 8
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 3 0
Tyrosine-protein kinase SYK inhibitor 4-[[3-[8-[(5,6-dimethoxy... 2 0
Scavenger receptor class B member 1 ligand 2-[9-[3-(4,6-dimeth... 1 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 6
Vascular endothelial growth factor receptor 2 and Platelet-der... 16 11
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 1 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 3 0
Adenosine receptor A2a and Adenosine receptor A1 ligand 5-[(7S... 6 1
Protein-cysteine N-palmitoyltransferase porcupine inhibitor N-... 4 4
Motilin receptor ligand SureCN2765637 family 1 1
Vascular endothelial growth factor receptor 2 ligand AGN-PC-04... 8 1
Serine/threonine-protein kinase pim-1 and Serine/threonine-pro... 2 3
Adenosine receptor A2a ligand 3-[(2-bromophenyl)methyl]-8-(fur... 2 0
Adenosine receptor A2a ligand 8-(furan-2-yl)-3-[2-[4-(1,3-thia... 2 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 25 5
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 29 1
Adenosine receptor A2a and Adenosine receptor A1 ligand 1-[(2-... 2 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Mitogen-activated protein kinase 14 inhibitor 4-[4-(4-fluoroph... 1 5
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 2
Adenosine kinase inhibitor AGN-PC-0757MS family 2 0
Gamma-aminobutyric acid receptor subunit gamma-2 and Gamma-ami... 2 0
Adenosine receptor A3 and Adenosine receptor A2a ligand (3R,4S... 1 0
RAC-alpha serine/threonine-protein kinase and RAC-gamma serine... 3 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Adenosine receptor A2a ligand SureCN8368237 family 1 0
Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor ... 2 2
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 1 0
Adenosine receptor A3 and Adenosine receptor A1 ligand AGN-PC-... 2 2
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 19 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Neuronal acetylcholine receptor subunit alpha-7 and 5-hydroxyt... 1 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Diacylglycerol O-acyltransferase 1 inhibitor SureCN2789698 family 2 8
Diacylglycerol O-acyltransferase 1 inhibitor 3-[[1-[5-[[2-(3-m... 1 1
Diacylglycerol O-acyltransferase 1 inhibitor ethyl 4-[5-[[2-(3... 5 8
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AGN-PC-074D... 4 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor SureCN14736... 4 0
Inosine-5'-monophosphate dehydrogenase 2 inhibitor AC1LAY14 fa... 2 1
Arachidonate 15-lipoxygenase and Nonstructural protein 1 inhib... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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