Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database. Cousin Family Names Seeds Members Leutinizing-hormone-releasing hormone inhibitor peptide Leupro... 43 911 Epidermal Growth Factor family 111 209 Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256 Insulin receptor Ligand Insulin, Porcine Family 61 205 Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259 Renin Inhibitor Remikiren Family 100 126 Bacterial outer membrane Inhibitor Daptomycin Family 6 50 Substance-P receptor Ligand GSK424887 Family 8 184 Growth hormone receptor Ligand EP-51216 Family 34 390 CBP-501 family 7 8 Renin Inhibitor Enalkiren Family 56 44 Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41 Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2 Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54 Glycylpeptide N-tetradecanoyltransferase Inhibitor SC-58272 Fa... 2 11 Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67 Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 50 17 Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60 Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12 Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2 Type-2 angiotensin II receptor Ligand PD-123319 Family 3 39 Endothelin B receptor Ligand IRL-2500 Family 34 87 Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14 Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7 Pol polyprotein inhibitor AC1LAD48 family 19 5 Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4 Renin and Pepsin A inhibitor tert-butyl N-[(2S)-1-[[2-[[(4S,5S... 4 0 Pol polyprotein inhibitor AC1LAQE0 family 13 4 Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10 Integrin beta-3 and Integrin alpha-V inhibitor 2-[1-[2-[[4-(1H... 6 2 Pol polyprotein inhibitor (2S)-4-(1H-benzimidazol-2-ylmethyl)-... 1 0 Protein farnesyltransferase subunit beta and Protein farnesylt... 3 0 Renin and Pepsin A inhibitor [(2S)-1-[[(2R)-1-[[(2S,3R)-1-cycl... 2 2 Pol polyprotein inhibitor AC1LA3L0 family 3 2 Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3 Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0 Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2 Prostaglandin D2 receptor 2 ligand SureCN2215286 family 7 5 Pol polyprotein and Renin inhibitor U-75875 family 12 1 Pol polyprotein inhibitor N-[(3R,4R,5R)-5-[[(2S)-1-(1H-benzimi... 5 4 Renin inhibitor (3R)-4-[[(2S,5S)-1-cyclohexyl-3-hydroxy-6-meth... 3 4 Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2 C-C chemokine receptor type 5 and Potassium voltage-gated chan... 11 0 C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1 Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0 Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0 Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0 Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3 Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1 Renin inhibitor (4S)-5-cyclohexyl-2,2-difluoro-4-[[(2S)-3-(1H-... 1 0 Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0 Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0 Pol polyprotein and Protease inhibitor 161186-51-2 family 5 0 Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-N-(3-imidazo... 1 0 Renin inhibitor tert-butyl N-[1-[[1-[[(3R,4S)-1-cyclohexyl-3,4... 2 2 Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 3 Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0 Melanocyte-stimulating hormone receptor and Melanocortin recep... 1 0 Growth hormone secretagogue receptor type 1 ligand CHEMBL52599... 1 0 Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
CFAM Mol ID
External ID
Functional Category
Molecule Name
CFAMM00435983 CHEMBL329818 Bioactive
ethyl 6-[[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]amino]-6-oxohexanoate CFAMM00435982 CHEMBL94923 Bioactive
SureCN9327709 CFAMM00435981 CHEMBL94731 Bioactive
[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl] 4-aminopiperidine-1-carboxylate CFAMM00435980 CHEMBL94827 Bioactive
[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl] N-methyl-N-[2-[methyl(morpholine-4-carbonyl)amino]ethyl]carbamate CFAMM00435979 CHEMBL94762 Bioactive
(2R)-4-(4-aminopiperidin-1-yl)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-4-oxobutanamide CFAMM00435978 CHEMBL327190 Bioactive
(2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-pyridin-2-ylhexan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-4-morpholin-4-yl-4-oxobutanamide
CFAM Mol ID
External ID
Functional Category
Molecule Name
Statistics of CFAM Database
490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
How to cite our database
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering.
Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
Last update by
2014.08.29
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Chen Yuzong Deputy
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