CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1581
Family Name Lysine--tRNA ligase and Dual specificity protein kinase CLK4 inhibitor 732983-37-8 family
No. of Seeds 4 No. of Other Members 27
Family Centroid CFAMM00325286 Functional Category Bioactive
Superfamily Insulin-like growth factor 1 receptor and Tyrosine-protein kinase JAK2 Binder Superfamily
Class Class 974

Cousin Family NamesSeedsMembers
Epidermal growth factor receptor Ligand Gefitinib Family 26 600
Gamma-secretase subunit APH-1B Inhibitor E2012 Family 3 67
Adenosine receptor A2a Ligand KW-6002 Family 18 195
Adenosine receptor A2a Ligand BIIB014 Family 26 92
Smoothened homolog Inhibitor LDE225 Family 3 76
RAF proto-oncogene serine/threonine-protein kinase Inhibitor R... 7 148
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 37
Heat shock protein HSP 90-alpha Inhibitor 8-benzo[1,3]dioxol-,... 5 83
Peptide deformylase, mitochondrial Inhibitor 8-(2,3,4-trimetho... 8 15
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Adenosine receptor A1 and Adenosine receptor A3 Ligand 4-metho... 1 16
Cytochrome P450 2D6 and Cytochrome P450 3A4 Inhibitor 2-[3-(4-... 7 128
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Adenosine receptor A1 and Adenosine receptor A3 Ligand 2-(4-me... 3 23
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
TGF-beta receptor type-1 Ligand SB-431542 Family 2 42
Adenosine receptor A1 and Adenosine receptor A2a Ligand 4-(fur... 7 15
Epidermal growth factor receptor Ligand 4-(5-bromoindole-3-yl)... 6 15
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Adenosine receptor A1 and Adenosine receptor A2a Ligand N-(2-(... 21 108
Reverse transcriptase Inhibitor Atevirdine Family 4 55
Reverse transcriptase Inhibitor UK-129485 Family 23 221
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Dual specificity mitogen-activated protein kinase kinase 1 inh... 10 54
Tyrosine-protein kinase JAK2 and Tyrosine-protein kinase JAK3 ... 1 15
3-phosphoinositide-dependent protein kinase 1 and Ribosomal pr... 10 4
Hepatocyte growth factor receptor and Receptor-type tyrosine-p... 12 26
Tyrosine-protein kinase Lck inhibitor AGN-PC-073GX8 family 12 1
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 6 7
Beta-1 adrenergic receptor and Beta-2 adrenergic receptor liga... 1 2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 39 10
Glucocorticoid receptor ligand (2R)-1,1,1-trifluoro-4-(2-metho... 2 5
Adenosine receptor A2b and Adenosine receptor A1 ligand SureCN... 52 12
Dual specificity protein kinase CLK1 and Dual specificity prot... 2 14
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 8 12
DNA-(apurinic or apyrimidinic site) lyase and Retinal dehydrog... 1 3
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL2... 3 8
Adenosine receptor A2b and Adenosine receptor A1 ligand MRS 17... 10 0
Neuropeptide Y receptor type 5 ligand SureCN5771669 family 2 3
Thyroid hormone receptor beta and Ferritin light chain ligand ... 1 35
Dual specificity tyrosine-phosphorylation-regulated kinase 1A ... 3 20
D(3) dopamine receptor and D(2) dopamine receptor ligand SureC... 5 4
Thyroid hormone receptor beta and Cruzipain ligand CHEMBL14730... 1 12
Adenosine receptor A2a and Adenosine receptor A1 ligand AGN-PC... 2 1
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 6 13
Cellular tumor antigen p53 and Lysosomal alpha-glucosidase inh... 1 6
Neuropeptide Y receptor type 5 ligand 3-[2-[6-[2-[(2-methylpro... 1 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 2 4
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 2 2
Adenosine receptor A1 and Adenosine receptor A3 ligand AGN-PC-... 6 8
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 2
Fatty-acid amide hydrolase 1 inhibitor 3-[(3R)-1-[4-(1-benzofu... 4 4
Serine/threonine-protein kinase PLK1 inhibitor AGN-PC-0A9RFQ f... 2 1
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9QGC ... 14 0
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-09ODY0 ... 2 5
MAP kinase-activated protein kinase 2 inhibitor AGN-PC-0A9RSG ... 6 5
cAMP-specific 3',5'-cyclic phosphodiesterase 4D and cAMP-speci... 2 4
Integrin alpha-V and Integrin beta-5 inhibitor SureCN2491273 f... 11 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Histamine H1 receptor and Histamine H4 receptor ligand 1H-benz... 2 7
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 6 0
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 5 7
Serine/threonine-protein kinase RIO2 and Serine/threonine-prot... 12 13
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 10
MAP kinase-activated protein kinase 2 inhibitor 4-fluoro-N-[4-... 25 1
MAP kinase-activated protein kinase 2 inhibitor N-[4-(4-oxospi... 3 0
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 2
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Hepatocyte growth factor receptor and Cytochrome P450 3A4 liga... 5 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 8 3
Insulin-like growth factor 1 receptor ligand GSK1220512A family 20 15
Macrophage colony-stimulating factor 1 receptor and Ephrin typ... 1 0
Vascular endothelial growth factor receptor 2 ligand AGN-PC-00... 8 1
Rho-associated protein kinase 1 and cAMP-dependent protein kin... 1 11
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 8 6
Serine/threonine-protein kinase TBK1 and Inhibitor of nuclear ... 2 8
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 3 6
Vascular endothelial growth factor receptor 2 and Aurora kinas... 4 3
Smoothened homolog inhibitor N-[3-(1H-benzimidazol-2-yl)phenyl... 2 1
Glycogen synthase kinase-3 beta inhibitor 2-(4-fluorophenyl)-N... 7 3
Bifunctional dihydrofolate reductase-thymidylate synthase and ... 7 16
Smoothened homolog and Mitogen-activated protein kinase 14 inh... 7 11
Growth hormone secretagogue receptor type 1 ligand SureCN36800... 14 42
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 3 0
Rho-associated protein kinase 1 inhibitor SureCN4007647 family 8 4
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Cathepsin K and Cathepsin S inhibitor 2-Cyano-pyrimidine, 17i ... 3 6
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 1
Nitric oxide synthase, inducible inhibitor SureCN5194847 family 24 48
Nitric oxide synthase, inducible inhibitor 2-[1-(2-imidazol-1-... 4 3
Glycogen synthase kinase-3 beta and Casein kinase I isoform ga... 3 0
Casein kinase I isoform gamma-2 and Casein kinase I isoform de... 5 2
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 11 1
Vascular endothelial growth factor receptor 2 and Serine/threo... 6 13
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 2 1
Nitric oxide synthase, inducible inhibitor N-(1,3-benzodioxol-... 1 0
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 3 14
Receptor tyrosine-protein kinase erbB-2 ligand SureCN4461871 f... 2 2
Adenosine receptor A2a and Cytochrome P450 3A4 ligand N-[6-(3,... 5 2
Aromatase inhibitor 2-(imidazol-1-ylmethyl)-6-methoxy-1-phenyl... 2 8
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-[5-(diflu... 7 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 1 1
Histone-arginine methyltransferase CARM1 inhibitor AGN-PC-00HE... 4 4
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[[2-(die... 12 2
Orexin receptor type 2 and Orexin receptor type 1 ligand 9-(4,... 2 5
Histamine H3 receptor and Sodium-dependent serotonin transport... 2 0
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 8-[(6,7... 6 8
Cathepsin K and Cathepsin S inhibitor SureCN4135077 family 2 0
Melanin-concentrating hormone receptor 1 ligand (1S,3S)-3-N-(7... 2 2
Vascular endothelial growth factor receptor 2 and Cytochrome P... 2 1
Mitogen-activated protein kinase 14 inhibitor SureCN4913214 fa... 1 2
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 4 1
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 6 0
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 2 6
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X2R ... 1 3
Cannabinoid receptor 2 ligand AGN-PC-03LKW5 family 24 5
Insulin-like growth factor 1 receptor ligand SureCN311483 family 3 0
Cell division cycle 7-related protein kinase inhibitor Pyrrolo... 2 6
Hepatocyte growth factor receptor ligand 4-pyridone analogue, ... 8 0
Rho-associated protein kinase 2 inhibitor AGN-PC-078WHL family 3 1
Insulin-like growth factor 1 receptor ligand AGN-PC-050GPS family 7 0
Insulin-like growth factor 1 receptor and Mitogen-activated pr... 6 0
Translocator protein inhibitor AGN-PC-04X3HY family 10 1
Cathepsin S and Cathepsin K inhibitor AGN-PC-078ZDC family 4 2
Epidermal growth factor receptor ligand Pyrido[3,4-d]pyrimidin... 3 1
D(2) dopamine receptor ligand AGN-PC-07C1V6 family 2 3
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 15 1
Adenosine receptor A2a and Adenosine receptor A1 ligand SureCN... 9 0
cAMP-specific 3',5'-cyclic phosphodiesterase 4D inhibitor Sure... 2 6
cGMP-inhibited 3',5'-cyclic phosphodiesterase B and cGMP-inhib... 1 1
Bifunctional epoxide hydrolase 2 and Arachidonate 5-lipoxygena... 3 0
Multidrug resistance-associated protein 1 and Cytochrome P450 ... 1 0
Tryptophan 5-hydroxylase 1 inhibitor (2S)-2-amino-3-[4-[5-[(3,... 1 3
3-carboxamide NP ZINC20411409 Family 14 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325261 CHEMBL1242100 Bioactive BAY-613606
CFAMM00325280 CHEMBL541400 Bioactive 2-[[7-(3,4-dimethoxyphenyl)imidazo[1,2-c]pyrimidin-5-yl]amino]pyridine-3-carboxamide;dihydrochloride
CFAMM00325286 CHEMBL1190711 Bioactive 732983-37-8
CFAMM00325254 CHEMBL1779347 Bioactive AGN-PC-0A9SGT

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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