CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15822
Family Name Substance-P receptor ligand (5S,10S)-5-(4-fluorophenyl)-10-(2-methoxy-5-propan-2-ylphenyl)-1,8-dioxa-4-azaspiro[5.5]undecane family
No. of Seeds 3 No. of Other Members 2
Family Centroid CFAMM00436054 Functional Category Bioactive
Superfamily Substance-P receptor Ligand Ezlopitant Superfamily
Class Class 120

Cousin Family NamesSeedsMembers
Beta adrenergic receptor ligand naphthol derivative Propranolo... 11 218
Serotonin re-uptake Inhibitor Fluoxetine Family 18 682
Alpha adrenergic receptor Ligand Phenoxybenzamine Family 4 63
Alpha-1B adrenergic receptor ligand Morpholine derivative Phen... 4 152
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha-1B adrenergic receptor ligand Phenylephrine analog Metho... 9 56
Beta-1 adrenergic receptor Ligand Nebivolol Family 5 22
Serine/threonine-protein kinase PLK1 Inhibitor On 019190.na Fa... 16 138
Melatonin receptor type 1A Ligand Agomelatine Family 12 164
Substance-P receptor Ligand Ezlopitant Family 10 207
Acolbifene family 10 115
Dapoxetine family 3 40
Potassium voltage-gated channel subfamily H member 2 and Sodiu... 33 83
M-phase inducer phosphatase 1 Inhibitor Naphthoquinone Analogs... 11 56
Extracellular calcium-sensing receptor Ligand Nps 568 Family 5 54
Histamine H3 receptor Ligand UCL-2138 Family 23 172
Alpha-1A adrenergic receptor and Alpha-1D adrenergic receptor ... 5 11
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 25 50
Adenosine receptor A3 and Muscarinic acetylcholine receptor M2... 4 31
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 41
Histamine H3 receptor and Sodium-dependent serotonin transport... 25 28
Delta-type opioid receptor and Kappa-type opioid receptor Liga... 5 11
Squalene synthase Inhibitor 3-[7'-(methoxy)-napht-2'-yl]-quinu... 53 30
Sodium-dependent dopamine transporter and Sodium-dependent nor... 6 13
5-hydroxytryptamine receptor 1A Ligand 9-methoxy-1,2,3,4-tetra... 7 10
Alpha-2A adrenergic receptor and Alpha-2B adrenergic receptor ... 2 3
Tubulin beta chain Inhibitor Colchinol Family 3 109
5-hydroxytryptamine receptor 2A Ligand 1-(2,6-dimethoxy-4-meth... 14 3
5-hydroxytryptamine receptor 1A ligand [(1S,2R)-8-methoxy-2-(p... 4 0
Muscarinic acetylcholine receptor M3 and Beta-2 adrenergic rec... 2 1
Transporter and Sodium-dependent serotonin transporter inhibit... 1 5
Sigma non-opioid intracellular receptor 1 ligand (1S,4R,5R)-7-... 2 7
Sodium-dependent dopamine transporter and Sodium-dependent ser... 2 6
Sodium-dependent serotonin transporter and Sodium-dependent no... 2 11
Substance-P receptor ligand SureCN6400808 family 2 0
Mu-type opioid receptor ligand 2-[[2-[(2R)-2-ethyl-4-(4-fluoro... 1 3
Sigma non-opioid intracellular receptor 1 ligand AGN-PC-0A9S9E... 1 0
2-[(1R,4aS,8aS)-4a-hydroxy-1-(4-methoxyphenyl)-2,3,4,5,6,7,8,8... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436055 CHEMBL327928 Bioactive (3S)-3-(2-methoxyphenyl)-10-phenyl-1-oxa-9-azaspiro[4.5]decane
CFAMM00436054 CHEMBL83716 Bioactive (5S,10S)-5-(4-fluorophenyl)-10-(2-methoxy-5-propan-2-ylphenyl)-1,8-dioxa-4-azaspiro[5.5]undecane
CFAMM00436057 CHEMBL83772 Bioactive (5S,10S)-5-(4-fluorophenyl)-10-[2-methoxy-5-(trifluoromethyl)phenyl]-1,8-dioxa-4-azaspiro[5.5]undecane

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27432 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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