CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1584
Family Name Calpain-2 catalytic subunit and Calpain-1 catalytic subunit inhibitor benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)pentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate family
No. of Seeds 8 No. of Other Members 8
Family Centroid CFAMM00325364 Functional Category Bioactive
Superfamily Calpain-1 catalytic subunit and Cathepsin B Binder Superfamily
Class Class 3403

Cousin Family NamesSeedsMembers
HIV protease Inhibitor Indinavir Family 36 211
HIV-1 protease Inhibitor Atazanavir Family 16 58
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
Amyloid beta A4 protein Inhibitor Florbetapir F-18 Family 8 265
Histone deacetylase 1 Inhibitor MS-275 Family 4 41
Substance-P receptor Ligand GSK424887 Family 8 184
Gamma-aminobutyric acid receptor Ligand E-2007 Family 7 118
CP-18770 family 6 27
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Fatty-acid amide hydrolase 1 Inhibitor Pyridin-3-yl 4-butoxybe... 10 5
Endothelin B receptor Ligand IRL-2500 Family 34 87
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Histone deacetylase 1 and Histone deacetylase 4 Inhibitor Cycl... 1 1
Renin inhibitor (2S,4S,5S)-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[... 3 0
Pol polyprotein inhibitor AC1LAD48 family 19 5
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Neutrophil elastase inhibitor benzyl N-[2-(4-aminophenyl)-6-ox... 4 23
Plasmepsin-1 and Plasmepsin-2 inhibitor Statine-like inhibitor... 13 5
Neutrophil elastase inhibitor SureCN7284457 family 4 6
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Pol polyprotein inhibitor Carbamic acid, ((2-hydroxy-1,4-bis(p... 21 1
Cathepsin L1 and Cathepsin K inhibitor benzyl N-[(2S)-1-oxo-3-... 1 1
Pol polyprotein and Protease inhibitor Palinavir family 1 0
Cellular tumor antigen p53 and DNA polymerase beta inhibitor C... 1 15
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Disintegrin and metalloproteinase domain-containing protein 17... 2 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Cruzipain and Cathepsin L1 inhibitor pyridin-3-ylmethyl N-[(2S... 7 4
Pol polyprotein inhibitor (2S,4S,5S)-5-acetamido-6-cyclohexyl-... 3 3
Integrin beta-3 and Integrin alpha-V inhibitor (2S)-3-[5-methy... 4 5
Beta-secretase 1 inhibitor (2S)-2-[(3S)-3-acetamido-3-butan-2-... 4 4
Metabotropic glutamate receptor 5 ligand AGN-PC-075X3Y family 2 6
Caspase-1 and Caspase-8 inhibitor (4S,7S,11aS)-2-(benzenesulfo... 3 0
B1 bradykinin receptor ligand AGN-PC-00CTAF family 1 3
Histone deacetylase 2 and Histone deacetylase 1 inhibitor 9H-f... 1 7
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16b ... 2 0
Pol polyprotein inhibitor AC1LAHRX family 4 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Integrin beta-3 and Integrin alpha-IIb inhibitor SureCN7013744... 2 3
Integrin beta-1 and Integrin alpha-5 inhibitor SureCN14453479 ... 3 5
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 2
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Pol polyprotein inhibitor Palinavir deriv. 13 family 1 0
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Renin and Cathepsin D inhibitor (4S)-5-cyclohexyl-2,2-difluoro... 4 1
Disintegrin and metalloproteinase domain-containing protein 17... 1 0
Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(... 2 1
Beta-secretase 1 and Cathepsin B inhibitor SureCN14347784 family 4 0
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
Neutrophil elastase inhibitor AGN-PC-0745BY family 1 0
Pol polyprotein inhibitor N-benzyl-2,2-difluoro-4-[[(2S)-3-met... 1 1
Protein-glutamine gamma-glutamyltransferase 2 and Coagulation ... 2 0
Metabotropic glutamate receptor 5 ligand N-[(5S,7R)-2-(3-chlor... 3 1


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325357 CHEMBL2316587 Bioactive AC1L1C2X
CFAMM00325370 CHEMBL132586 Bioactive Calpain Inhibitor XII
CFAMM00325368 CHEMBL132773 Bioactive AGN-PC-075L3S
CFAMM00325359 CHEMBL439798 Bioactive benzyl N-[1-[[1,2-dioxo-1-(pyridin-3-ylmethylamino)pentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
CFAMM00325365 CHEMBL132839 Bioactive benzyl N-[1-[[1,2-dioxo-1-(2-pyridin-2-ylethylamino)pentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate
CFAMM00325358 CHEMBL134142 Bioactive AGN-PC-075L5G
CFAMM00325364 CHEMBL130114 Bioactive benzyl N-[1-[[1,2-dioxo-1-(pyridin-2-ylmethylamino)pentan-3-yl]amino]-4-methyl-1-oxopentan-2-yl]carbamate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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