CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15866
Family Name Adenosine receptor A1 and Adenosine receptor A2a ligand 7-methoxy-2-phenyl-1H-1,8-naphthyridin-4-one family
No. of Seeds 2 No. of Other Members 0
Family Centroid CFAMM00307622 Functional Category Bioactive
Superfamily Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Superfamily
Class Class 976

Cousin Family NamesSeedsMembers
Hypoxia-inducible factor 1-alpha Inhibitor Hif-1alpha Family 7 107
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 13
Serine/threonine-protein kinase mTOR Inhibitor AZD8055 Family 2 2
Peptide deformylase, mitochondrial Inhibitor Epiroprim Family 5 68
Tyrosine kinase Inhibitor PKI166 Family 17 198
Peptide deformylase, mitochondrial Inhibitor 5-(4-methoxypheno... 5 61
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 9 Inhibi... 10 35
Cyclin-dependent kinase 2 and Cyclin-dependent kinase 4 Inhibi... 19 48
Glycogen synthase kinase-3 beta and Mitogen-activated protein ... 8 8
Sodium channel protein type 5 subunit alpha Ligand Enecadin Fa... 1 11
cGMP-specific 3',5'-cyclic phosphodiesterase Inhibitor SK&F-96... 5 83
Adenosine receptor A1 and Adenosine receptor A2a ligand NSC658... 8 54
Cathepsin S and Cathepsin K inhibitor AGN-PC-088VBO family 3 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor SureCN6... 19 11
DNA-(apurinic or apyrimidinic site) lyase and Ras-related prot... 1 5
Prostaglandin D2 receptor ligand 3-[2-methoxy-6-[2-(4-methoxyp... 2 12
Prelamin-A/C and Nuclear receptor ROR-gamma ligand CHEMBL13704... 1 7
Adenosine receptor A1 and Adenosine receptor A2a ligand (6E)-6... 2 2
Lethal factor and Dual specificity protein kinase CLK4 inhibit... 1 3
Methionine--tRNA ligase inhibitor 2-[3-[(2-ethoxy-5-iodo-3-met... 9 32
Methionine--tRNA ligase inhibitor 2-[3-[(5-bromo-2-ethoxy-3-me... 9 11
Methionine--tRNA ligase, cytoplasmic and Methionine--tRNA liga... 8 6
Methionine--tRNA ligase inhibitor SureCN7818124 family 1 9
Prostaglandin D2 receptor ligand 2-[3-[2-methoxy-6-[2-(4-metho... 4 12
Prostaglandin D2 receptor ligand 2-methoxy-N-[2-(4-methoxyphen... 2 5
Prostaglandin D2 receptor ligand 1-[3-[2-methoxy-6-[2-(4-metho... 6 16
Adenosine receptor A3 ligand AGN-PC-08WSLM family 5 22
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 17
Poly [ADP-ribose] polymerase 1 inhibitor 4-[1-[3-(4-oxo-1H-qui... 1 3
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 2 1
Serine/threonine-protein kinase Chk1 inhibitor SureCN6387344 f... 6 11
cGMP-dependent 3',5'-cyclic phosphodiesterase and cAMP and cAM... 3 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 1 1
Xanthine dehydrogenase/oxidase inhibitor 5-(2-amino-4-oxo-1H-p... 8 30
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 2 5
5-hydroxytryptamine receptor 2C and 5-hydroxytryptamine recept... 2 2
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 3 10
Type-1 angiotensin II receptor ligand 2-ethyl-6-methoxy-N-[[4-... 2 0
Insulin-like growth factor 1 receptor ligand 3-[8-amino-1-(4-e... 9 0
Nuclear receptor ROR-gamma and Prelamin-A/C ligand ST50133141 ... 1 0
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 2 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436199 CHEMBL97895 Bioactive 7-ethoxy-2-phenyl-1H-1,8-naphthyridin-4-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

25240 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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