CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15872
Family Name Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-[[(2R)-2-[[4-(benzenesulfonyl)piperazine-1-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoate family
No. of Seeds 3 No. of Other Members 1
Family Centroid CFAMM00436223 Functional Category Bioactive
Superfamily Carbonic anhydrase 1 and Carbonic anhydrase 2 Binder Superfamily 17
Class Class 2185

Cousin Family NamesSeedsMembers
Alpha adrenergic receptor ligand ergot alkaloid Dihydroergota... 7 12
HIV protease Inhibitor Indinavir Family 36 211
HIV protease Inhibitor Saquinavir Family 64 428
Gastrin/cholecystokinin type B receptor ligand peptide Pentaga... 26 1171
Somatostatin receptor type 2 ligand octapeptide Octreotide Family 27 172
Indoleamine 2,3-dioxygenase 1 Inhibitor L-tryptophan Family 8 328
Bacterial outer membrane Inhibitor Daptomycin Family 6 50
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
CBP-501 family 7 8
Cholecystokinin receptor type A Ligand A-71378 Family 77 23
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Integrin beta-3 Inhibitor Elarofiban Family 28 45
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Delta-type opioid receptor and Gastrin/cholecystokinin type B ... 19 0
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Cholecystokinin receptor type A Ligand VL-0395 Family 12 117
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
Angiotensin-converting enzyme and Endothelin-converting enzyme... 2 10
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Vasopressin V1a receptor and Vasopressin V1b receptor Ligand D... 10 19
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Histone deacetylase Inhibitor ST-5732 Family 8 6
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Cathepsin K inhibitor [(3S)-1-(1H-indole-6-carbonyl)-4,4-dimet... 2 4
5-hydroxytryptamine receptor 6 and 5-hydroxytryptamine recepto... 1 11
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Cathepsin L1 inhibitor Bio2_000267 family 9 1
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 1 0
Caspase-1 inhibitor (3S)-4-oxo-3-[[(2S)-4-oxo-2-propan-2-yl-4-... 3 0
Prothrombin and Cationic trypsin inhibitor tert-butyl N-[(2R)-... 4 3
Prothrombin inhibitor (2S)-N-[(6-carbamimidoylpyridin-3-yl)met... 2 14
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 4 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 0
Disintegrin and metalloproteinase domain-containing protein 17... 5 9
Disintegrin and metalloproteinase domain-containing protein 17... 4 0
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Somatostatin receptor type 2 ligand (2R,3S)-N-[(5-amino-1,3-di... 2 5
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Survival motor neuron protein and Menin inhibitor CHEMBL151109... 1 11
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Somatostatin receptor type 4 ligand methyl 5-(diaminomethylide... 2 34
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 2 4
Coagulation factor X inhibitor SureCN4172349 family 7 3
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
Prothrombin and Trypsin-1 inhibitor 1-[2-(4-benzylpiperidin-1-... 2 2
Renin and Potassium voltage-gated channel subfamily H member 2... 9 2
Collagenase 3 and 72 kDa type IV collagenase inhibitor (2R)-N-... 3 2
Muscarinic acetylcholine receptor M3 ligand [(3R)-1-[2-(1H-ind... 1 0
Neuropeptide Y receptor type 5 ligand 2-indol-1-yl-N-[4-[(prop... 7 6
Prothrombin and Tissue-type plasminogen activator inhibitor 2-... 4 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 0
Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitor (2R)-... 1 3
Pancreatic alpha-amylase and Gastrin/cholecystokinin type B re... 7 1
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 2 4
C-C chemokine receptor type 2 ligand 2-[4-(5-amino-1H-indol-3-... 3 2
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 4 1
72 kDa type IV collagenase and Matrix metalloproteinase-9 inhi... 1 1
Phospholipase D1 and Phospholipase D2 inhibitor SureCN10311349... 2 14
Somatostatin receptor type 5 ligand L-817,818 family 2 0
Neprilysin and Angiotensin-converting enzyme inhibitor (2S)-2-... 1 4
Renin inhibitor tert-butyl N-[1-[[1-[[1-cyclohexyl-4,4-difluor... 5 0
Endothelin B receptor and Endothelin-1 receptor ligand 2-[[(2R... 17 10
Bombesin receptor subtype-3 ligand SureCN13887096 family 3 1
Neprilysin and Endothelin-converting enzyme 1 inhibitor (2S)-2... 5 0
Endothelin-1 receptor and Endothelin B receptor ligand 2-[[(2R... 5 3
Neuromedin-B receptor and Gastrin-releasing peptide receptor l... 6 4
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 2 2
Integrin beta-1 and Integrin alpha-4 inhibitor (2S)-2-[(1-benz... 2 1
Somatostatin receptor type 4 and Somatostatin receptor type 5 ... 3 4
Matrix metalloproteinase-9 and 72 kDa type IV collagenase inhi... 2 4
Interstitial collagenase and Stromelysin-1 inhibitor CHEMBL887... 1 0
Carbonic anhydrase 2 and Carbonic anhydrase 1 inhibitor [2-(me... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436225 CHEMBL329824 Bioactive tert-butyl (2S)-6-amino-2-[[(2R)-2-[[1-(benzenesulfonyl)piperidine-4-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoate
CFAMM00436224 CHEMBL91696 Bioactive tert-butyl (2S)-6-amino-2-[[(2R)-3-(1H-indol-3-yl)-2-[[4-(4-methylphenyl)sulfonylpiperazine-1-carbonyl]amino]propanoyl]amino]hexanoate
CFAMM00436223 CHEMBL329684 Bioactive tert-butyl (2S)-6-amino-2-[[(2R)-2-[[4-(benzenesulfonyl)piperazine-1-carbonyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanoate

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

24638 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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