CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15893
Family Name Gonadotropin-releasing hormone receptor ligand methyl 4-[2-[[(2S)-2-[5-[1-(3-azabicyclo[2.2.2]octan-3-yl)-2-methyl-1-oxopropan-2-yl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]pyridine-2-carboxylate family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00436281 Functional Category Bioactive
Superfamily 5-hydroxytryptamine receptor Ligand Metergolin Superfamily
Class Class 447

Cousin Family NamesSeedsMembers
5-hydroxytryptamine receptor 1B and 5-hydroxytryptamine recept... 14 2769
D(1A) dopamine receptor ligand ergot alkaloid Methylergonovine... 22 170
5-hydroxytryptamine receptor 3A Ligand Dolasetron Family 12 171
HIV-1 protease Inhibitor Atazanavir Family 16 58
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
5-hydroxytryptamine receptor Ligand Metergolin Family 2 11
Hepatocyte growth factor receptor Ligand Arq 197 Family 10 400
Glycogen synthase kinase-3 beta and Protein kinase C beta type... 5 53
Substance-P receptor Ligand GSK424887 Family 8 184
Growth hormone receptor Ligand EP-51216 Family 34 390
D(3) dopamine receptor Ligand SB-277011 Family 13 178
TGF-beta receptor type-1 Ligand LY2157299 Family 13 56
Gastrin/cholecystokinin type B receptor Ligand PD136450 Family 53 117
C-C chemokine receptor type 3 Ligand YM-344031 Family 19 106
Lethal factor Inhibitor GM6001 Family 50 435
Somatostatin receptor type 2 Ligand L-054852 Family 13 88
Carbonic anhydrase 2 Inhibitor N-[2-(1h-indol-5-yl)-butyl]-4-s... 12 70
Substance-K receptor and Substance-P receptor Ligand L-732138 ... 8 147
Cathepsin B and Cathepsin K Inhibitor Z-arg-leu-val-agly-ile-v... 3 19
cGMP-inhibited 3',5'-cyclic phosphodiesterase A and Cytochrome... 9 40
Acetylcholinesterase and Cholinesterase Inhibitor Lipocrine Fa... 18 36
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Poly [ADP-ribose] polymerase 1 Inhibitor 1,7,8,9-tetrahydro-1,... 19 64
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[n... 12 10
RAC-gamma serine/threonine-protein kinase Inhibitor A-443654 F... 67 59
Transient receptor potential cation channel subfamily V member... 6 23
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand C[c... 20 18
5-hydroxytryptamine receptor 2C Ligand N-(6-phenoxypyridin-3-y... 9 69
Cytochrome P450 11B1, mitochondrial and Aromatase Inhibitor 5-... 4 10
Mitogen-activated protein kinase 14 Inhibitor N-(4-fluorobenzy... 19 32
Kinesin-like protein KIF11 Inhibitor Methyl 7-tert-butyl-9h-ca... 2 9
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 24 64
Sodium-dependent serotonin transporter Inhibitor 3-(3-aminocyc... 94 23
cAMP-specific 3',5'-cyclic phosphodiesterase 4A and cAMP-speci... 3 29
Endothelin B receptor Ligand IRL-2500 Family 34 87
Gamma-aminobutyric acid receptor subunit alpha-1 and Gamma-ami... 12 72
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
Vasopressin V2 receptor Ligand YM-35278 Family 33 38
Histone deacetylase Inhibitor ST-5732 Family 8 6
C-C chemokine receptor type 5 ligand AC1LAJEM family 4 14
Pol polyprotein inhibitor pyridin-2-ylmethyl N-[(2R)-1-[[(2S,3... 15 8
Cathepsin K and Cathepsin S inhibitor dipeptidyl nitrile, 16f ... 3 18
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 6 2
Gonadotropin-releasing hormone receptor ligand 1-(3-azabicyclo... 5 0
Gonadotropin-releasing hormone receptor ligand 5-[2-[[(2S)-2-[... 7 58
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 17 28
Neutrophil collagenase and Stromelysin-3 inhibitor AC1MORIH fa... 7 9
Sodium-dependent serotonin transporter and D(2) dopamine recep... 13 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Calpain-2 catalytic subunit and Calpain-1 catalytic subunit in... 8 8
MAP kinase-activated protein kinase 2 inhibitor CHEMBL1233942 ... 6 0
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 5 2
Calpain-1 catalytic subunit and Cathepsin B inhibitor AGN-PC-0... 5 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 1 2
Somatostatin receptor type 2 ligand tert-butyl (2S)-6-amino-2-... 2 15
Cholecystokinin receptor type A and Gastrin/cholecystokinin ty... 4 53
Survival motor neuron protein and Nonstructural protein 1 inhi... 1 18
Prelamin-A/C and Microtubule-associated protein tau inhibitor ... 1 16
Growth hormone-releasing hormone receptor ligand ethyl (1S)-1'... 3 2
Mitogen-activated protein kinase 1 and Nonstructural protein 1... 1 33
Cannabinoid receptor 2 ligand [(4R,4aS,8aR)-4-hydroxy-4-phenyl... 2 41
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 4 4
MAP kinase-activated protein kinase 2 and Mitogen-activated pr... 4 0
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 2 2
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 5 1
Gonadotropin-releasing hormone receptor and Cytochrome P450 3A... 3 0
Substance-P receptor ligand N-[(2S)-5-[3,5-bis(trifluoromethyl... 4 6
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 18 3
Neuropeptide Y receptor type 5 ligand SureCN3380922 family 2 6
Melanin-concentrating hormone receptor 2 ligand N-[(1R)-1'-(9H... 4 1
RAC-alpha serine/threonine-protein kinase and cAMP-dependent p... 3 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 14 2
Acetylcholinesterase and Cholinesterase inhibitor AGN-PC-009GH... 8 10
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Melanin-concentrating hormone receptor 1 and Melanin-concentra... 3 1
Substance-P receptor ligand [3,5-bis(trifluoromethyl)phenyl]-[... 17 1
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Egl nine homolog 1 inhibitor 1'-[(3-methylpyridin-2-yl)methyl]... 6 4
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 2 0
RAC-alpha serine/threonine-protein kinase inhibitor 5-[5-[(2S)... 3 1
Gonadotropin-releasing hormone receptor ligand 1-adamantyl-[2-... 3 1
Tankyrase-1 inhibitor N-[4-[(4S)-5,5-dimethyl-2-oxo-4-phenyl-1... 3 2
Gonadotropin-releasing hormone receptor ligand SureCN7899418 f... 12 4
Neutrophil collagenase and Stromelysin-3 inhibitor [3-[[1-amin... 3 2
Substance-P receptor and Substance-K receptor ligand N-methyl-... 2 2
Gonadotropin-releasing hormone receptor ligand 1-[2-(3,5-dimet... 2 0
Gonadotropin-releasing hormone receptor ligand 1-(7-azabicyclo... 2 0
CGMP-dependent protein kinase inhibitor AGN-PC-0761UG family 1 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 5 0
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 3 4


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436281 CHEMBL331145 Bioactive methyl 4-[2-[[(2S)-2-[5-[1-(3-azabicyclo[2.2.2]octan-3-yl)-2-methyl-1-oxopropan-2-yl]-2-(3,5-dimethylphenyl)-1H-indol-3-yl]propyl]amino]ethyl]pyridine-2-carboxylate
CFAMM00436280 CHEMBL79639 Bioactive 1-(3-azabicyclo[2.2.2]octan-3-yl)-2-[2-(3,5-dimethylphenyl)-3-[(2S)-1-[2-[2-(methoxymethyl)pyridin-4-yl]ethylamino]propan-2-yl]-1H-indol-5-yl]-2-methylpropan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

22920 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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