CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM15903
Family Name Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha and Protein farnesyltransferase subunit beta inhibitor SureCN9235512 family
No. of Seeds 4 No. of Other Members 3
Family Centroid CFAMM00436329 Functional Category Bioactive with Natural Product
Superfamily Streptokinase A and Pol polyprotein Binder Superfamily
Class Class 414

Cousin Family NamesSeedsMembers
Parathyroid hormone/parathyroid hormone-related peptide recept... 55 256
Insulin receptor Ligand Insulin, Porcine Family 61 205
Insulin-degrading enzyme inhibitor cyclic polypeptide Bacitrac... 30 259
Renin Inhibitor Remikiren Family 100 126
Growth hormone receptor Ligand EP-51216 Family 34 390
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Renin Inhibitor Enalkiren Family 56 44
Renin Inhibitor (h-261)boc-his-pro-phe-his-leu(oh)-val-ile-his... 33 41
Integrin alpha-V and Integrin beta-3 Inhibitor SB-223245 Family 27 36
Cathepsin B and Cathepsin K Inhibitor Z-ala-leu-his-agly-ile-v... 3 2
Renin Inhibitor Sul-pro-phe-n-mehis-lva-ile-amp Family 47 54
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Delta-type opioid receptor Ligand H-poa-ser-gly-phe-leu-thr-oh... 5 12
Cytochrome P450 11B1, mitochondrial Inhibitor Methyl 3-(1-benz... 3 12
Type-1 angiotensin II receptor Ligand [sar1,tdf3]angii Family 135 2
Type-2 angiotensin II receptor Ligand PD-123319 Family 3 39
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
Bombesin receptor subtype-3 ligand SureCN3515839 family 1 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2R)-1-[[3-[[(2R... 19 4
Pol polyprotein inhibitor Hydroxyethylene deriv. 12 family 13 10
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 11 22
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Pol polyprotein inhibitor AC1LA3L0 family 3 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 8
Lysosomal Pro-X carboxypeptidase inhibitor N-[(2S)-1-[(2S)-2-(... 1 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 2
Renin inhibitor propan-2-yl (3R)-2-hydroxy-3-[[(2S)-3-(1H-imid... 4 0
Renin and Cathepsin D inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-... 2 2
RAC-alpha serine/threonine-protein kinase inhibitor 2-[(3,4-di... 3 1
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 6 3
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Pol polyprotein inhibitor propan-2-yl N-[(2S)-1-[[(2S,3S,5R)-3... 6 2
Delta-type opioid receptor ligand ethyl N-[3-[(R)-[4-[ethyl(me... 2 6
Prothrombin and Cationic trypsin inhibitor (2S)-1-[(2R)-3,3-di... 5 9
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 3 1
C-C chemokine receptor type 5 ligand (2R)-2-[(3S,4S)-3-[[4-(2-... 5 0
C-C chemokine receptor type 5 ligand AC1MHRXO family 5 1
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(2S,3S,5S)-5-(... 2 0
Renin inhibitor tert-butyl N-[1-[[1-[[(2S,3S)-1-cyclohexyl-3-h... 1 0
Renin inhibitor (2S)-N-[(2S,3S)-1-cyclohexyl-3-hydroxy-5-(3-im... 4 0
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Renin inhibitor tert-butyl N-[(2S)-1-[[(2S)-1-[[(1R,2S)-3-cycl... 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 2 0
Carbonic anhydrase 2 and Carbonic anhydrase 4 inhibitor (2S)-2... 2 4
Renin inhibitor (2R)-2-benzyl-N-[(2S)-1-[[(2S,3R,4S)-1-cyclohe... 6 0
Renin inhibitor [(2S)-1-[[(2R)-1-[[(2S,3S)-1-cyclohexyl-3-hydr... 1 0
Angiotensin-converting enzyme 2 inhibitor MLN-4760 family 1 3
Histidinol dehydrogenase inhibitor (3S)-3-amino-1-(2,4-difluor... 5 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436326 CHEMBL334004 Bioactive (2S)-5-amino-2-[[(3S)-2-[(2S)-2-[3-(1H-imidazol-5-yl)propanoylamino]-3,3-dimethylbutanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-5-oxopentanoic acid
CFAMM00436330 CHEMBL333700 Bioactive (2S)-2-[[(3S)-2-[(2S)-2-[[2-(1H-imidazol-5-yl)acetyl]amino]-3-methylbutanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]amino]-4-methylsulfanylbutanoic acid
CFAMM00436329 CHEMBL331976 Bioactive SureCN9235512

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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