CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1599
Family Name Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ligand N-[2-[1-(2,3-dihydro-1,4-benzodioxin-3-ylmethyl)piperidin-4-yl]ethyl]-2-(2-methoxyphenyl)acetamide family
No. of Seeds 1 No. of Other Members 13
Family Centroid CFAMM00161096 Functional Category Bioactive with Natural Product
Superfamily Alpha-2C adrenergic receptor and Alpha-2B adrenergic receptor Binder Superfamily 3
Class Class 3406

Cousin Family NamesSeedsMembers
Beta-1 adrenergic receptor Ligand Esmolol Family 5 39
Beta adrenergic receptor Ligand Dipivefrin Family 3 55
HIV-1 protease Inhibitor Lopinavir Family 4 25
Noradrenergic re-uptake Inhibitor Reboxetine Family 26 206
Alpha adrenergic receptor Ligand Bevantolol Family 4 48
Muscarinic acetylcholine receptor Ligand Methantheline Family 6 8
Renin Inhibitor Aliskiren Family 28 107
Growth hormone secretagogue receptor type 1 Ligand TZP-101 Family 28 263
Substance-P receptor Ligand DA-5018 Family 14 73
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 2 23
Cytochrome P450 2D6 and Delta-type opioid receptor Ligand 4-(s... 17 381
A disintegrin and metalloproteinase with thrombospondin motifs... 7 119
5-hydroxytryptamine receptor 1A Ligand Robalzotan Family 9 41
Voltage-dependent L-type calcium channel Ligand PD173212 Family 24 104
Cathepsin F Inhibitor Benzoyl-tyrosine-alanine-methyl Ketone F... 34 55
Plasmepsin-1 and Plasmepsin-2 Inhibitor PS-777621 Family 11 13
Disintegrin and metalloproteinase domain-containing protein 17... 25 36
Potassium voltage-gated channel subfamily A member 3 Ligand 2-... 9 92
Histamine H3 receptor Ligand A-349821 Family 49 228
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 9 12
Melanin-concentrating hormone receptor 1 Ligand N-(1-benzylpip... 9 57
Oxytocin receptor Ligand [mpa1, D-tyr(et)2, D-tic7]ot Family 43 26
Kappa-type opioid receptor Ligand 3-(1-benzylpiperidin-4-yloxy... 24 54
D(2) dopamine receptor Ligand Epidepride Family 31 66
Glycine receptor subunit beta Ligand ORG-25543 Family 10 153
Growth hormone secretagogue receptor type 1 ligand 2-amino-2-m... 1 0
Alpha-2B adrenergic receptor and Alpha-2C adrenergic receptor ... 3 2
E3 ubiquitin-protein ligase XIAP inhibitor N-METHYLALANYL-3-ME... 3 14
Substance-P receptor ligand AGN-PC-075NP5 family 4 8
Histone deacetylase and Histone deacetylase 3 inhibitor (3S,6S... 1 0
5-hydroxytryptamine receptor 1A and Alpha-1D adrenergic recept... 1 0
Baculoviral IAP repeat-containing protein 3 and E3 ubiquitin-p... 7 1
C-C chemokine receptor type 3 and C-C chemokine receptor type ... 3 4
C-C chemokine receptor type 1 ligand SureCN8184421 family 11 10
Integrin beta-1 and Integrin alpha-4 inhibitor (2R)-3-[4-(2-me... 18 1
Cathepsin S and Cathepsin L1 inhibitor benzyl N-[(2S)-1-oxo-1-... 2 2
Scytalone dehydratase inhibitor 2-cyano-N-[(1S,2R)-1-(2-cyanop... 5 0
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 2
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 1 0
Bifunctional epoxide hydrolase 2 and Cytochrome P450 2C9 inhib... 2 1
Cathepsin K inhibitor (2S)-2-[[2-(3,4-dimethoxyphenyl)acetyl]a... 1 1
Peptidyl-prolyl cis-trans isomerase FKBP1A inhibitor SureCN101... 2 6
Prothrombin inhibitor (2S)-N-[(4-aminocyclohexyl)methyl]-1-(2,... 1 0
Beta-lactamase inhibitor CHEMBL1566697 family 1 5
(2S)-1-[2-[4-(8-methoxy-2-oxochromen-3-yl)phenoxy]acetyl]pyrro... 1 0


CFAM Mol ID

External ID

Functional Category

Molecule Name


Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

48716 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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