CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM1600
Family Name RAF proto-oncogene serine/threonine-protein kinase and Serine/threonine-protein kinase B-raf inhibitor 3idp family
No. of Seeds 3 No. of Other Members 5
Family Centroid CFAMM00325500 Functional Category Bioactive
Superfamily Smoothened homolog and Dipeptidyl peptidase 4 Binder Superfamily
Class Class 2257

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Benzodiazepine receptor Ligand Midazolam Family 5 160
Metabotropic glutamate receptor 5 Ligand ADX-48621 Family 15 444
C-X-C chemokine receptor type 4 Ligand AMD-070 Family 12 800
Transient receptor potential cation channel subfamily V member... 16 295
Transient receptor potential cation channel subfamily V member... 15 457
Cyclin-dependent kinase 2 Inhibitor Seliciclib Family 29 292
Farnesyltransferase beta subunit, putative Inhibitor Zarnestra... 10 56
Vascular endothelial growth factor receptor 2 Ligand Ptk787/zk... 5 38
Fibroblast growth factor receptor 2 and Fibroblast growth fact... 11 86
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
Tyrosine-protein kinase JAK2 Inhibitor INCB18424 Family 3 130
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor Lig... 14 234
Adenosine receptor A1 Ligand SLV320 Family 6 79
Protein kinase C alpha type and Protein kinase C beta type Inh... 16 86
Aurora kinase B and Aurora kinase C Inhibitor GSK1070916 Family 53 580
HCV NS4B protein Inhibitor Clemizole Family 2 43
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Corticotropin-releasing factor receptor 1 Ligand R121919 Family 26 84
Histamine H3 receptor Ligand SCH79687 Family 11 29
Beta-secretase 1 Inhibitor 6-[2-(1h-indol-6-yl)ethyl]pyridin-2... 10 43
Beta-secretase 1 Inhibitor N~3~-(3-pyridin-3-ylbenzyl)pyridine... 31 66
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2,6-di... 13 14
Adenosine receptor A3 Ligand 2,6-bis(4-chlorophenyl)-9h-purine... 4 12
D(2) dopamine receptor and D(3) dopamine receptor Ligand 4-(4-... 6 48
Steroid 17-alpha-hydroxylase/17,20 lyase and Aromatase Inhibit... 18 109
Vascular endothelial growth factor receptor 1 and Vascular end... 6 23
Epidermal growth factor receptor Ligand PD-158780 Family 98 89
Arachidonate 5-lipoxygenase Inhibitor 2,4,5-triarylimidazole A... 3 16
Metabotropic glutamate receptor 5 Ligand 3-(4-pyridin-2-yl-imi... 6 5
Cyclin-dependent kinase 1 Inhibitor CGP-60474 Family 14 103
Mitogen-activated protein kinase 3 and RAF proto-oncogene seri... 8 5
Epidermal growth factor receptor Ligand N4-(3-chlorophenyl)qui... 7 39
RAC-gamma serine/threonine-protein kinase and Rho-associated p... 16 46
Adenosine receptor A3 Ligand 2-(5-chloro-1h-benzo[d]imidazol-2... 7 51
Mitogen-activated protein kinase 14 and Tyrosine-protein kinas... 3 9
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Adenosine receptor A1 and Adenosine receptor A2a Ligand 2-phen... 8 11
Dipeptidyl peptidase 4 Inhibitor (5-phenyl-3h-benzo[d]imidazol... 5 13
Mitogen-activated protein kinase kinase kinase 8 and Stromelys... 6 53
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
RAF proto-oncogene serine/threonine-protein kinase Inhibitor L... 219 124
Glycogen synthase kinase-3 beta Inhibitor CHIR-98023 Family 5 6
Glycogen synthase kinase-3 beta Inhibitor 4-(5-bromo-1h-indol-... 7 18
Serine/threonine-protein kinase mTOR Inhibitor 4-(2-(1h-indol-... 2 15
Proto-oncogene tyrosine-protein kinase Src Inhibitor CGP-62464... 3 10
Peptide deformylase, mitochondrial Inhibitor 7h-pyrrolo[3,2-f]... 2 10
Sodium-dependent serotonin transporter Inhibitor 6-chloro-2-pi... 5 35
Sodium channel protein type 1 subunit alpha and Sodium channel... 10 14
Adenosine receptor A3 and Adenosine receptor A2a ligand 5-buty... 3 13
Tyrosine-protein kinase Lck and Tyrosine-protein kinase HCK in... 8 7
Neuronal acetylcholine receptor subunit alpha-7 and Potassium ... 7 3
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 4 2
Aurora kinase B inhibitor AGN-PC-07ZZ0Y family 2 12
Tyrosine-protein kinase BTK and Tyrosine-protein kinase Lyn in... 7 7
Platelet-activating factor receptor ligand AGN-PC-0750SP family 4 0
Platelet-activating factor receptor ligand SureCN9383514 family 4 1
Adenosine kinase inhibitor 5-(4-chlorophenyl)-6-[2-(6-morpholi... 8 8
Aurora kinase A and Aurora kinase B inhibitor 3uol family 6 5
Melanin-concentrating hormone receptor 1 and Potassium voltage... 8 27
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 4 27
Type-1B angiotensin II receptor ligand SureCN683399 family 3 0
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 4 0
Mitogen-activated protein kinase 14 inhibitor AGN-PC-03XQYG fa... 7 1
Dihydrofolate reductase and Bifunctional dihydrofolate reducta... 5 0
Prelamin-A/C inhibitor CHEMBL1472945 family 1 32
Dihydrofolate reductase inhibitor 6-[[(4-chloronaphthalen-1-yl... 2 1
Cannabinoid receptor 2 and Cannabinoid receptor 1 ligand AGN-P... 5 0
Insulin-like growth factor 1 receptor ligand AGN-PC-09QIDN family 1 3
Lysosomal Pro-X carboxypeptidase inhibitor N-[(1S)-1-(5,6-dich... 3 21
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 3 10
Lysosomal Pro-X carboxypeptidase inhibitor 1-[(2S)-2-(5,6-dich... 2 2
Corticosteroid 11-beta-dehydrogenase isozyme 1 and Nuclear rec... 9 6
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 10 1
TGF-beta receptor type-1 ligand 3-(6-methylpyridin-2-yl)-N-phe... 21 0
Cyclin-dependent kinase 2 and Glycogen synthase kinase-3 beta ... 3 3
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 9 2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10... 2 0
Mitogen-activated protein kinase 14 inhibitor 4-(2-chloropheny... 4 0
Protein kinase C zeta type and Cyclin-dependent kinase 2 inhib... 2 13
Protein kinase C theta type and Leucine-rich repeat serine/thr... 1 1
Serine/threonine-protein kinase pim-2 and Serine/threonine-pro... 6 1
Cannabinoid receptor 2 ligand 8-(2-chlorophenyl)-9-cyclopropyl... 4 5
Somatostatin receptor type 3 ligand tert-butyl 4-[(3R)-3-(5-ph... 2 2
Transient receptor potential cation channel subfamily V member... 4 0
Transient receptor potential cation channel subfamily V member... 6 2
Melanin-concentrating hormone receptor 1 ligand 3-[(1R,3R,6S)-... 6 6
Smoothened homolog inhibitor N-[4-chloro-3-(5-phenyl-1H-imidaz... 4 1
Serine/threonine-protein kinase mTOR and Phosphatidylinositol ... 6 2
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand N-[1-... 5 3
Somatostatin receptor type 3 and Potassium voltage-gated chann... 3 3
Urokinase plasminogen activator surface receptor ligand 3-(1H-... 4 0
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subun... 7 4
Receptor-type tyrosine-protein kinase FLT3 and Aurora kinase A... 2 0
Adenosine kinase inhibitor 4-[2-[5-(4-chlorophenyl)-6-piperazi... 3 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 6 3
Cholinesterase inhibitor 4-[4,5-diphenyl-1-[7-(1,2,3,4-tetrahy... 2 1
Corticotropin-releasing factor receptor 1 and Corticotropin-re... 5 2
Cyclin-dependent kinase 1 and Proto-oncogene tyrosine-protein ... 5 13
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 16 7
Mitogen-activated protein kinase 10 inhibitor CYCLOPROPYL-{4-[... 2 1
Tyrosine-protein kinase Lck and Proto-oncogene tyrosine-protei... 3 0
Nociceptin receptor and Potassium voltage-gated channel subfam... 5 2
RAC-alpha serine/threonine-protein kinase and RAC-beta serine/... 10 0
Dipeptidyl peptidase 4 inhibitor 7-(aminomethyl)-6-(2-chloroph... 2 5
Mitogen-activated protein kinase 14 inhibitor 5-[2-(2,6-dichlo... 1 0
Gamma-aminobutyric acid receptor subunit pi and GABA theta sub... 4 3
Alpha-1B adrenergic receptor and Alpha-1D adrenergic receptor ... 1 0
Coagulation factor X inhibitor SureCN1652469 family 2 1
Transient receptor potential cation channel subfamily V member... 1 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
G2/mitotic-specific cyclin-B2 and Cyclin-dependent kinase 1 in... 2 1
Proto-oncogene tyrosine-protein kinase Src and Fibroblast grow... 3 4
Gonadotropin-releasing hormone receptor ligand SureCN3275214 f... 5 0
Tyrosine-protein kinase ABL1 and Proto-oncogene tyrosine-prote... 1 0
Gonadotropin-releasing hormone receptor ligand 4-[[4-[2-(4-ter... 3 3
Cannabinoid receptor 1 and Cannabinoid receptor 2 ligand SureC... 7 0
Metabotropic glutamate receptor 1 ligand AGN-PC-00FV3S family 2 0
Prostaglandin E synthase inhibitor AGN-PC-014WPB family 1 0
Gonadotropin-releasing hormone receptor ligand AGN-PC-00AWCA f... 1 0
Tyrosine-protein kinase Lck inhibitor (3S)-3-[(1S)-1-[[4-(benz... 14 0
Cannabinoid receptor 1 ligand AGN-PC-07CPJ5 family 9 14
Prostaglandin E synthase inhibitor AGN-PC-00C2TD family 2 0
Lysosomal Pro-X carboxypeptidase inhibitor 1-[6-[(2S)-2-(5,6-d... 2 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00325500 CHEMBL1197798 Bioactive 3idp
CFAMM00325503 CHEMBL1950909 Bioactive 2-[1-[6-[(2S)-2-(5,6-dichloro-1H-benzimidazol-2-yl)pyrrolidin-1-yl]pyrimidin-4-yl]piperidin-3-yl]-5-pyridin-3-yl-3,4-dihydro-1H-isoquinoline

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

27621 visits since 2014 .........

 



Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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