CFam Chemical Families Database
BIDD Pharmainformatics Databases
 
   
Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16033
Family Name cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-dihydro-1-benzofuran-5-yl)-2-[5-[4-(4-methylpiperazine-1-carbonyl)phenyl]furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one family
No. of Seeds 2 No. of Other Members 1
Family Centroid CFAMM00436734 Functional Category Bioactive with Natural Product
Superfamily cGMP-specific 3',5'-cyclic phosphodiesterase Binder Superfamily 2
Class Class 97

Cousin Family NamesSeedsMembers
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor indole... 28 2712
ostatin receptor 5 Ligand Pasireotide Diaspartate Family 11 151
Neuronal acetylcholine receptor subunit alpha-4 Ligand TC-5619... 3 61
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 12 197
Genomic RNA for RNA-dependent RNA polymerase gene (clone HCV-J... 4 42
72 kDa type IV collagenase and Matrix metalloproteinase-9 Inhi... 37 265
C-C chemokine receptor type 2 and C-C motif chemokine 2 Ligand... 3 52
von Willebrand factor Inhibitor Auryntricarboxylic Acid (ata) ... 12 81
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 2-benzyl-6-... 9 80
Integrin beta-3 Inhibitor L-756568 Family 8 59
Vascular endothelial growth factor receptor 1 Ligand Lycogarub... 6 292
DNA-dependent protein kinase catalytic subunit Inhibitor 8-(1h... 3 85
Inosine-5'-monophosphate dehydrogenase 2 Inhibitor 3-(furan-3-... 3 44
Platelet-derived growth factor receptor alpha and Platelet-der... 4 54
Adenosine receptor A1 and Adenosine receptor A2a Ligand SB-298... 53 320
Delta-type opioid receptor and Mu-type opioid receptor Ligand ... 18 72
5-hydroxytryptamine receptor 1A and D(2) dopamine receptor lig... 7 44
5-hydroxytryptamine receptor 1A and Sodium-dependent serotonin... 7 11
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 14 48
Collagenase 3 inhibitor N-[[3-[5-[[(1R)-1-cyclohexyl-2-(methyl... 4 2
Histamine H3 receptor and Cytochrome P450 2D6 ligand AGN-PC-00... 18 32
Histamine H3 receptor ligand AGN-PC-00BG7Z family 11 49
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 10 50
Sodium-dependent serotonin transporter and 5-hydroxytryptamine... 8 12
Glutamate receptor ionotropic, NMDA 2D and Glutamate receptor ... 2 21
Disintegrin and metalloproteinase domain-containing protein 17... 2 1
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 21 11
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(2,3-... 2 0
Growth hormone secretagogue receptor type 1 ligand 2-amino-N-[... 3 3
Histamine H3 receptor ligand SureCN2784306 family 5 3
Serine/threonine-protein kinase B-raf inhibitor furan-based co... 6 3
Mu-type opioid receptor ligand AGN-PC-075GBK family 4 4
NS5B protein inhibitor AC1O5AET family 3 1
MAP kinase-activated protein kinase 2 inhibitor 5-(4-cyanophen... 3 8
Serine/threonine-protein kinase pim-2 and cGMP-dependent prote... 8 1
Histone deacetylase 6 and Histone deacetylase 1 inhibitor N-hy... 3 2
Substance-P receptor ligand (3R)-4-[3,5-bis(trifluoromethyl)be... 2 3
Substance-P receptor ligand 1-[4-(2-methoxyphenyl)piperazin-1-... 11 12
Mu-type opioid receptor and Mu-type opioid receptor ligand (3S... 6 2
MAP kinase-activated protein kinase 2 inhibitor 4-[5-[[2-(2-me... 3 4
Estrogen receptor and Estrogen receptor beta ligand N-[(2R)-4-... 7 11
Proto-oncogene tyrosine-protein kinase receptor Ret and Vascul... 5 14
Macrophage colony-stimulating factor 1 receptor ligand 5-cyano... 1 0
D(2) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 1 0
Mu-type opioid receptor ligand MITRAGYNINE family 2 8
Cathepsin K inhibitor N-[(2S)-4-methyl-1-[2-[4-(2-methylpropox... 4 0
Substance-P receptor ligand SureCN2139814 family 7 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor 3-(1,3-... 1 0
Gonadotropin-releasing hormone receptor ligand 2-[2-(4-methoxy... 1 1
RAC-alpha serine/threonine-protein kinase inhibitor Isoquinoli... 1 0
Melatonin receptor type 1B and Melatonin receptor type 1A liga... 3 9
D(3) dopamine receptor and 5-hydroxytryptamine receptor 1A lig... 2 0
Substance-P receptor ligand AGN-PC-0D60L0 family 2 7
cGMP-specific 3',5'-cyclic phosphodiesterase inhibitor CHEMBL4... 6 2
5-hydroxytryptamine receptor 1D and 5-hydroxytryptamine recept... 1 0
Bombesin receptor subtype-3 ligand 2-[[(E)-furan-2-ylmethylide... 2 4
Collagenase 3 inhibitor SureCN1316041 family 4 3


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436734 CHEMBL342197 Bioactive 3-(2,3-dihydro-1-benzofuran-5-yl)-2-[5-[4-(4-methylpiperazine-1-carbonyl)phenyl]furan-2-carbonyl]-3,4-dihydro-1H-pyrrolo[3,4-b]quinolin-9-one
CFAMM00436733 CHEMBL433708 Bioactive AGN-PC-0755EN

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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