CFam Chemical Families Database
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Click on CFAM IDs and names to search or view in CFAM, click on external IDs to view the entity in its source database.

CFam Family Information

CFAM Family ID CFFBM16073
Family Name Tripeptidyl-peptidase 2 inhibitor (2S)-2-amino-1-[(2S)-5-chloro-2-(5-propyl-1H-imidazol-2-yl)-2,3-dihydroindol-1-yl]propan-1-one family
No. of Seeds 1 No. of Other Members 0
Family Centroid CFAMM00436897 Functional Category Bioactive
Superfamily Farnesyltransferase beta subunit, putative and Protein farnesyltransferase subunit beta Inhibitor L-778123 Superfamily
Class Class 1486

Cousin Family NamesSeedsMembers
Alpha-2 adrenergic receptor Ligand Dexmedetomidine Family 32 639
Histamine H1 receptor Ligand Mizolastine Family 14 603
Cannabinoid receptor 1 Ligand CP-945598 Family 18 173
cAMP-specific 3',5'-cyclic phosphodiesterase 4D Inhibitor Arof... 3 196
RAC-gamma serine/threonine-protein kinase Inhibitor AZD5363 Fa... 35 69
Vascular endothelial growth factor receptor 2 Ligand XL999 Family 11 87
Kappa-type opioid receptor Ligand Brl 52974 Family 2 27
Histamine H3 receptor and Histamine H4 receptor Ligand Clobenp... 31 38
D(4) dopamine receptor Ligand L-745,870 Family 30 205
Histamine H3 receptor Ligand SCH79687 Family 11 29
Farnesyltransferase beta subunit, putative and Protein farnesy... 20 81
Alpha-1A adrenergic receptor and Alpha-1B adrenergic receptor ... 5 7
Alpha-1A adrenergic receptor Ligand A-315456 Family 7 17
Melanocortin receptor Ligand Ac-his-dnal(2)-arg-trp-nh2 Family 112 67
Melanocortin receptor 3 and Melanocortin receptor 4 Ligand Ac-... 38 60
Proto-oncogene tyrosine-protein kinase Src Inhibitor BMS-27970... 41 59
Aromatase and Cytochrome P450 26A1 Inhibitor Liarozole Family 4 1
Histamine H3 receptor Ligand 4-(2-(phenylamino)ethyl)-1h-imida... 5 16
Melanocortin receptor Ligand Ac-his-dphe(3,4-dicl)-arg-trp-nh2... 10 14
Bombesin receptor subtype-3 and Gastrin-releasing peptide rece... 42 7
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 0
Prothrombin and Cationic trypsin inhibitor (2S)-N-[(2S)-1-(1H-... 4 15
Prothrombin inhibitor SureCN5854779 family 4 9
Prothrombin inhibitor SureCN5856722 family 3 16
Mu-type opioid receptor and Mu-type opioid receptor ligand Sur... 5 10
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 1 7
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 0
5-hydroxytryptamine receptor 3A and 5-hydroxytryptamine recept... 2 1
Macrophage colony-stimulating factor 1 receptor ligand SureCN1... 28 9
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 13 3
Prolyl endopeptidase inhibitor SureCN8938520 family 2 1
Histamine H4 receptor ligand SureCN602132 family 1 8
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 1 2
Dipeptidyl peptidase 9 and Dipeptidyl peptidase 8 inhibitor Su... 16 5
Gastrin/cholecystokinin type B receptor and Cholecystokinin re... 3 3
C-C chemokine receptor type 5 and Potassium voltage-gated chan... 21 32
Protein farnesyltransferase/geranylgeranyltransferase type-1 s... 9 3
Coagulation factor X and Prothrombin inhibitor 2-carboxyindole... 2 8
Tyrosine-protein kinase JAK1 inhibitor CHEMBL2206623 family 10 11
Coagulation factor X inhibitor SureCN8289965 family 4 5
Neuronal acetylcholine receptor subunit alpha-4 and Neuronal a... 5 4
Sodium- and chloride-dependent glycine transporter 1 and Sodiu... 4 8
Melanin-concentrating hormone receptor 1 ligand AGN-PC-075X3N ... 1 7
Histamine H3 receptor ligand 1-[4-(1H-imidazol-5-ylmethyl)pipe... 1 2
Vascular endothelial growth factor receptor 2 ligand (3Z)-3-[5... 4 11
Platelet-derived growth factor receptor beta and Vascular endo... 5 12
Macrophage colony-stimulating factor 1 receptor and Cytochrome... 10 0
Tyrosine-protein kinase JAK2 inhibitor N-[3-(3-chlorophenyl)-1... 12 4
Tyrosine-protein kinase SYK inhibitor N-tert-butyl-2-(6-chloro... 2 0
Tyrosine-protein kinase JAK3 and Tyrosine-protein kinase JAK2 ... 12 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 3
Histone deacetylase 1 inhibitor 1-methyl-N-[(1S)-7-oxo-1-(5-qu... 2 1
RAF proto-oncogene serine/threonine-protein kinase and Serine/... 4 3
Prothrombin inhibitor 2-[4-methyl-5-[[[2-[6-methyl-2-oxo-3-(2-... 1 0
Macrophage colony-stimulating factor 1 receptor and Receptor-t... 2 0
Matrilysin and Stromelysin-1 inhibitor (2R)-N-[(1S)-1-(1H-benz... 3 0
Serine/threonine-protein kinase B-raf inhibitor 1-[2-[[4-[2-cy... 2 0
Nitric oxide synthase, inducible and Nitric oxide synthase, br... 2 0
Mitogen-activated protein kinase 1 and Aurora kinase A inhibit... 16 3
Poly [ADP-ribose] polymerase 1 inhibitor AGN-PC-07R96X family 7 1
Sodium- and chloride-dependent glycine transporter 1 and Potas... 3 0
Inosine-5'-monophosphate dehydrogenase inhibitor N-(4-chloroph... 1 2
Sodium channel protein type 9 subunit alpha and Sodium channel... 7 0


CFAM Mol ID

External ID

Functional Category

Molecule Name

CFAMM00436897 CHEMBL344682 Bioactive (2S)-2-amino-1-[(2S)-5-chloro-2-(5-propyl-1H-imidazol-2-yl)-2,3-dihydroindol-1-yl]propan-1-one

Statistics of CFAM Database

 
CFAM currently contains 490,279 molecules in 87,136 families, 34,880 superfamilies and 11,643 classes.
 

How to cite our database

 
C. Zhang, L. Tao, C. Qin, P. Zhang, S.Y. Chen, X. Zeng, F. Xu, Z. Chen, S.Y. Yang and Y.Z. CFam: A Chemical Families Database Based on Iterative Selection of Functional Seeds and Seed-Directed Compound Clustering. Nucl. Acids Res. 43 (D1): D558-D565 (2015) (First published online: November 20, 2014).
 

Last update by

 
2014.08.29
 

 

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Dr. Chen Yuzong

Deputy Director of Center for Computational Science and Engineering
Professor in Department of Pharmacy
National University of Singapore, Singapore


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